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Multichain Immune Recognition Receptor Signaling

Part of the Advances in Experimental Medicine and Biology Book Series (volume 640)

Editors: Sigalov, Alexander B.

DOI: 10.1007/978-0-387-09789-3

ISBN: 978-0-387-09788-6

Publisher: Springer New York - Springer Journals

Jan 1, 2008

1 - 10 of 22 Chapters

LitStream

T-Cell Receptor

Rojo, Jose M.; Bello, Raquel; Portolés, Pilar

Pages: 1 –11

[The T-cell antigen receptor complex (TCR/CD3) is a cell surface structure that defines the T lymphocyte lineage, where it fulfills two basic functions, namely antigen recognition and triggering of signals needed to mount adequate responses to foreign aggression and/or to undergo differentiation....
LitStream

B-Cell Receptor

Brezski, Randall J.; Monroe, John G.

Pages: 12 –21

[The subunit structure of the B-cell antigen receptor (BCR) and its associated compart-mentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed...
LitStream

Fc Receptors

Powell, Maree S.; Hogarth, P. Mark

Pages: 22 –34

[The aggregation of cell surface Fc receptors by immune complexes induces a number of important antibody-dependent effector functions. It is becoming increasingly evident that the organization of key immune proteins has a significant impact on the function of these proteins. Comparatively little...
LitStream

Natural Killer Cell Receptors

Biassoni, Roberto

Pages: 35 –52

[Natural killer (NK) cells are an important arm of the innate immune response that are directly involved in the recognition and lysis of virus-infected and tumor cells. Such function is under the control of a complex array of germline-encoded receptors able to deliver either inhibitory or...
LitStream

Platelet Glycoprotein VI

Jung, Stephanie M.; Moroi, Masaaki

Pages: 53 –63

[Glycoprotein VI (GPVI) is a membrane glycoprotein unique to platelets and has been identified as a physiological receptor for collagen. Damage to a vessel wall exposes the subendothelial component collagen to platelets in the blood flow. Interaction of platelets with collagen via the receptor...
LitStream

Clustering Models

Schamel, Wolfgang W.A.; Reth, Michael

Pages: 64 –73

[Ligand binding to the multichain immune recognition receptors (MIRRs) leads to receptor triggering and subsequent lymphocyte activation. MIRR signal transduction pathways have been extensively studied, but it is still not clear how binding of the ligand to the receptor is initially communicated...
LitStream

Segregation Models

Dopfer, Elaine P.; Swamy, Mahima; Siegers, Gabrielle M.; Molnar, Eszter; Yang, Jianying; Schamel, Wolfgang W. A.

Pages: 74 –81

[Many antigen receptors of the immune system belong to the family of multichain immune recognition receptors (MIRRs). Binding of ligand (antigen) to MIRR results in receptor phosphorylation, triggering downstream signaling pathways and cellular activation. How ligand binding induces this...
LitStream

Kinetic Proofreading Model

Goldstein, Byron; Coombs, Daniel; Faeder, James R.; Hlavacek, William S.

Pages: 82 –94

[Kinetic proofreading is an intrinsic property of the cell signaling process. It arises as a consequence of the multiple interactions that occur after a ligand triggers a receptor to initiate a signaling cascade and it ensures that false signals do not propagate to completion. In order for an...
LitStream

Serial Triggering Model

Rachmilewitz, Jacob

Pages: 95 –102

[T-cells recognize a foreign antigen when presented on antigen-presenting cells (APCs) in the context of a peptide bound to major histocompatibility complex (MHC). Ihe recognition of an antigen takes place at the T-cell: APC contact site where an “immune synapse” is formed and the multichain...
LitStream

Conformational Model

Risueño, Ruth M.; Ortiz, Angel R.; Alarcón, Balbino

Pages: 103 –112

[The failure to identify changes in the crystal structure of the T-cell antigen receptor (TCR) α/β ectodomains beyond the ligand-binding complementarity-determining region loops is most probably responsible for conformational changes having been relegated to a second plane as a mechanism of...

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