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V(D)J Recombination

Part of the Advances in Experimental Medicine and Biology Book Series (volume 650)

Editors: Ferrier, Pierre

DOI: 10.1007/978-1-4419-0296-2

ISBN: 978-1-4419-0295-5

Publisher: Springer New York - Springer Journals

Dec 21, 2009

1 - 10 of 15 Chapters

LitStream

Chapter 1Early Steps of V(D)J Rearrangement: Insights from Biochemical Studies of RAG-RSS Complexes

Swanson, Patrick C.; Kumar, Sushil; Raval, Prafulla

Pages: 1 –15

[V(D)J recombination is initiated by the synapsis and cleavage of a complementary (12/23) pair of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins. Our understanding of these processes has been greatly aided by the development of in vitro biochemical assays of RAG binding and...
LitStream

Chapter 2Regulation of RAG Transposition

Matthews, Adam G. W.; Oettinger, Marjorie A.

Pages: 16 –31

[V(D)J recombination is initiated by the lymphoid specific proteins RAG1 and RAG2, which together constitute the V(D)J recombinase. However, the RAG1/2 complex can also act as a transposase, inserting the broken DNA molecules generated during V(D)J recombination into an unrelated piece of DNA....
LitStream

Chapter 3Recent Insights into the Formation of RAG-Induced Chromosomal Translocations

Brandt, Vicky L.; Roth, David B.

Pages: 32 –45

[Chromosomal translocations are found in many types of tumors, where they may be either a cause or a result of malignant transformation. In lymphoid neoplasms, however, it is clear that pathogenesis is initiated by any of a number of recurrent DNA rearrangements. These particular translocations...
LitStream

Chapter 4V(D)J Recombination Deficiencies

de Villartay, Jean-Pierre

Pages: 46 –58

[V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B- and T-lymphocytes. The analysis of human patients with Severe Combined Immune Deficiency (SCID) has contributed...
LitStream

Chapter 5Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene Regulation

Bolland, Daniel J.; Wood, Andrew L.; Corcoran, Anne E.

Pages: 59 –72

[V(D)J recombination in lymphocytes is the cutting and pasting together of antigen receptor genes in cis to generate the enormous variety of coding sequences required to produce diverse antigen receptor proteins. It is the key role of the adaptive immune response, which must potentially combat...
LitStream

Chapter 6Genetic and Epigenetic Control of V Gene Rearrangement Frequency

Feeney, Ann J.

Pages: 73 –81

[The antibody repertoire is enormous and reflects the power of combinatorial and junctional diversity to generate a vast repertoire with a moderate number of V, D and J gene segments. However, although there are many VH and VK gene segments, the usage of these genes is highly unequal. In this...
LitStream

Chapter 7Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Chain Repertoire in Man and Mouse

Jouvin-Marche, Evelyne; Fuschiotti, Patrizia; Marche, Patrice Noël

Pages: 82 –92

[Most T-lymphocytes express a highly specific antigen receptor (TCR) on their cell surface, consisting of a clonotypic αß-heterodimer. Both α- and β chains are products of somatic rearrangements of V, (D) and J gene segments encoded on the respective loci. The qualitative, quantitative and...
LitStream

Chapter 8Germline Transcription: A Key Regulator of Accessibility and Recombination

Abarrategui, Iratxe; Krangel, Michael S.

Pages: 93 –102

[The developmental control of V(D)J recombination is imposed at the level of chromatin accessibility of recombination signal sequences (RSSs) to the recombinase machinery. Cis-acting transcriptional regulatory elements such as promoters and enhancers play a central role in the control of...
LitStream

Chapter 9Dynamic Regulation of Antigen Receptor Gene Assembly

Thomas, Lance R.; Cobb, Robin Milley; Oltz, Eugene M.

Pages: 103 –115

[A hallmark feature of adaptive immunity is the production of lymphocytes bearing an enormous repertoire of receptors for foreign antigens. This repertoire is generated early in B and T-cell development by the process of V(D)J recombination, which randomly assembles functional immunoglobulin (Ig)...
LitStream

Chapter 10Molecular Genetics at the T-Cell Receptor β Locus: Insights into the Regulation of V(D)J Recombination

Bonnet, Marie; Ferrier, Pierre; Spicuglia, Salvatore

Pages: 116 –132

[The V(D)J recombination machinery assembles antigen receptor genes from germline V,D and J segments during lymphocyte development. In αβT cells, this leads to the production of the T-cell receptor (TCR) α and β chains. Notably, V(D)J recombination at the Tcrb locus is tightly controlled at...

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