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Molecular Mechanisms of Spondyloarthropathies

Part of the Advances in Experimental Medicine and Biology Book Series (volume 649)

Editors: López-Larrea, Carlos; Díaz-Peña, Roberto

DOI: 10.1007/978-1-4419-0298-6

ISBN: 978-1-4419-0297-9

Publisher: Springer New York - Springer Journals

Nov 28, 2009

1 - 10 of 23 Chapters

LitStream

Chapter 1Clinical Assessment in the Spondyloarthropathies

Wittoek, Ruth; Mielants, Herman

Pages: 1 –16

[In order to measure disease activity, progression and response to therapy, it is important to use accurate, reliable and feasible outcome measures that can ideally be used in longitudinal cohorts, clinical trials and clinical practice.]
LitStream

Chapter 2Imaging in Spondyloarthritis

Maksymowych, Walter P.

Pages: 17 –36

[The role of imaging in the evaluation and management of SpA has experienced a resurgence of interest with the introduction of MRI and more sophisticated sonographic technologies. Several approaches have been developed to score plain radiographic abnormalities in the spine and sacroiliac joints...
LitStream

Chapter 3Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Chondrocalcinosis

Armas, Jácome Brugues; Couto, Ana Rita; Bettencourt, Bruno Filipe

Pages: 37 –56

[The authors describe the main clinical and radiological findings of common enthesopathic disorders—spondylarthritis (SpA), chondrocalcinosis/calcium pyrophosphate dehydrate crystal deposition disease (CPPD CDD) and diffuse idiopathic skeletal hyperostosis (DISH), stressing similarities and...
LitStream

Chapter 4The Enthesis Organ Concept and Its Relevance to the Spondyloarthropathies

Benjamin, Michael; McGonagle, Dennis

Pages: 57 –70

[A characteristic feature of the spondyloarthropathies is inflammation at tendon or ligament attachment sites. This has traditionally been viewed as a focal abnormality, even though the inflammatory reaction intrinsic to enthesitis may be quite extensive. We argue that the diffuse nature of the...
LitStream

Chapter 5Synovial and Mucosal Immunopathology in Spondyloarthritis

Vandooren, Bernard; Tak, Paul P.; Baeten, Dominique

Pages: 71 –84

[Chronic inflammation of musculoskeletal structures is the most prominent disease manifestation of SpA. More specifically, the axial disease affects the spine, the sacroiliac joints and the hips. Peripheral disease includes peripheral arthritis, with a preference for asymmetrical inflammation of...
LitStream

Chapter 6Bone Loss in the Spondyloarthropathies: Role of Osteoclast, RANKL, RANK and OPG in the Spondyloarthropathies

Anandarajah, Allen P.; Schwarz, Edward M.

Pages: 85 –99

[Bone loss is a common finding in the spondyloarthropathies. It may be localized and present as erosions or be generalized and cause osteoporosis. The pathogenesis of bone loss in the spondyloarthropathies is yet to be fully understood. There is however increasing evidence to support a role for...
LitStream

Chapter 7RANKL/RANK as Key Factors for Osteoclast Development and Bone Loss in Arthropathies

Leibbrandt, Andreas; Penninger, Josef M.

Pages: 100 –113

[Osteoporosis or rheumatoid arthritis are bone diseases affecting hundreds of millions of people worldwide and thus pose a tremendous burden to health care. Ground-breaking discoveries made in basic science over the last decade shed light on the molecular mechanisms of bone metabolism and bone...
LitStream

Chapter 8Bone Formation Versus Bone Resorption in Ankylosing Spondylitis

Schett, Georg

Pages: 114 –121

[Ankylosing spondylitis (AS) and other forms of seronegative spondylarthritis (SpA) are characterized by two major processes in joints—the first is chronic inflammation and the second is progressive ankylosis. Both features go hand-in-hand and determine the clinical picture of disease, which is...
LitStream

Chapter 9Biomarkers in Spondyloarthropathies

Chen, Chun-Hsiung; Yu, David Tak Yan; Chou, Chung-Tei

Pages: 122 –132

[The study of biomarkers in spondyloarthropathy (SpA) has emerged to be a very important field of research. This is particularly because the two commonly used biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), are of very low sensitivity and specificity. The second...
LitStream

Chapter 10Therapy of Spondyloarthritides

Braun, Jürgen

Pages: 133 –147

[Ankylosing spondylitis (AS) is the major subtype and a major outcome of an interrelated group of rheumatic diseases now named as spondyloarthritides (SpA). The most important clinical features of this group are inflammatory back pain (IBP), asymmetric peripheral oligoarthritis, predominantly of...

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