Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

DeepDyve requires Javascript to function. Please enable Javascript on your browser to continue.

Application of Peptide-Based Prodrug Chemistry in Drug Development

Part of the SpringerBriefs in Pharmaceutical Science & Drug Development Book Series

DOI: 10.1007/978-1-4614-4875-4

ISBN: 978-1-4614-4874-7

Publisher: Springer New York - Springer Journals

Aug 18, 2012

LitStream

Chapter 1Introduction

De, Arnab

Pages: 1 –13

[This chapter introduces diabetes, an ancient disease that continues to affect diverse populations in modern times and the various types of diabetes are discussed. Insulin has been traditionally used to treat the disease. However, the one significant limitation of using insulin is that an insulin...
LitStream

Chapter 2Application of Prodrug Chemistry to GLP-1

De, Arnab

Pages: 15 –21

[It is impressed upon the reader how a prodrug at the biologically active N-terminal end of GLP could be utilized to extend and improve the pharmacodynamics of this peptide hormone. The quality of an ideal prodrug and the different strategies that could be potentially considered for constructing...
LitStream

Chapter 3Experimental Procedures

De, Arnab

Pages: 23 –29

[Various procedures for synthesis of peptides by Boc and Fmoc-based methods are described. Synthesis of depsipeptides and N-terminal hydroxyl peptide synthesis are illustrated. The various peptides are characterised by mass spectrometry and analytical HPLC. The rate constant for the dissociation...
LitStream

Chapter 4Characterization of Prodrugs

De, Arnab

Pages: 31 –51

[Synthesis of a model peptide GLP1-oxyntomodulin is described to demonstrate that relatively large peptides can be synthesized using methods in the last chapter. The synthesis of Classes 1–4 prodrugs using various drug scaffolds are described. The structural nature of the side chain (especially β...
LitStream

Chapter 5Conclusion

De, Arnab

Pages: 53 –60

[Clinical studies have revealed that GLP-1 therapy might be intrinsically safer than insulin therapy because of its glucose dependent action, thus eliminating the chances of hypoglycaemia. This book discusses the prodrug strategy as a means to extend the half life of GLP-1 which otherwise has a...

results per page

Prev
1
Next

Browse All eBooks