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A Picture is Worth a Thousand Tables

Editors: Krause, Andreas; O'Connell, Michael

DOI: 10.1007/978-1-4614-5329-1

ISBN: 978-1-4614-5328-4

Publisher: Springer US - Springer Journals

Sep 28, 2012

1 - 10 of 21 Chapters

Available

Concepts and Principles of Clinical Data Graphics

Krause, Andreas

Pages: 3 –21

[Graphics are an essential tool for detecting and analyzing structure in data, developing statistical models, presenting results, and communicating about data and results. Drug development is still largely based on tables and listings, and graphics are an underutilized resource. Processing the...
Available

Graphics for Exploratory Analysis and Data Discovery in the Life Sciences

O’Connell, Michael; Cook, Ian; Luo, Difei; Patel, Josh

Pages: 23 –39

[Life Sciences data are complex. In the pharmaceutical industry, vast quantities of patient-level safety and efficacy data are collected, managed, analyzed, and reported in bringing new medicines to market. Clinical trial operations data, involving sites, investigators, milestones, and budgets...
Available

Grables: Visual Displays That Combine the Best Attributes of Graphs and Tables

Bradstreet, Thomas E.

Pages: 41 –69

[A grable combines the emergent features of a graph with the precise quantities of a table into a single display. Its purpose is to accommodate a wider variety of visual tasks and a possibly wider audience, than either a graph or a table can address alone. The best principles of visual perception...
Available

The Use of Figures in Epidemiological Publications: A Survey of Current Practice and Consequent Recommendations

Andersen, Elisabeth Wreford; Pocock, Stuart J.

Pages: 71 –83

[The aims of this survey are to document the current use of figures in epidemiological publications and to make proposals for future practice. To do this, the authors identified all 181 analytical epidemiology articles from 10 major medical journals in the period June to August 2008. For each...
Available

Use of Graphics for Studies with Small Sample Sizes: A Simulated Case Study of an Early-Phase Asset for Treatment of Type 2 Diabetes Mellitus

Shortino, Denise; Walker, Ann; Miskell, Andrew

Pages: 87 –97

[Graphics play an important role in understanding clinical data and the metabolic area of drug research is no exception. Challenges of early-phase clinical research include unpowered studies with small sample sizes (approximately 8–12 subjects per group), relatively short study durations, and the...
Available

Exploring Pharmacokinetic and Pharmacodynamic Data

Roosen, Charles; Pugh, Richard; Nicholls, Andrew

Pages: 99 –115

[The recent trend towards Bayesian and adaptive study designs has led to a growth in the field of pharmacokintetics and pharmacodynamics (PK/PD). The mathematical models used for PK/PD analysis can be extremely computationally intensive and particularly sensitive to messy data and anomalous...
Available

(Interactive) Graphics for Biomarker Assessment

Merz, Michael

Pages: 117 –138

[Biomarkers have become cornerstones of modern drug development, improving assessment of both efficacy and safety of new molecules. Use of graphical data exploration can help to maximize information output from biomarker data and improve efficiency of the data analysis process. The chapter...
Available

Graphical Displays for Biomarker Data

Zucknick, Manuela; Hielscher, Thomas; Sill, Martin; Benner, Axel

Pages: 139 –169

[Analysis of high-dimensional biomarker data is in general of exploratory nature and aims to discover or dissect subgroups of patients sharing a specific pattern of biomarker measurements. One major challenge is to extract the relevant markers from the extremely large pool of measured markers....
Available

Statistical Graphics in Clinical Oncology

Gilder, Kye

Pages: 173 –198

[Oncology clinical trials are often complex leading to years of research and generation of vast amounts of data. Statistical graphics play an invaluable role in transforming these multifaceted data into crisp and simplified visuals that assist researchers to quickly and accurately study the...
Available

Efficient and Effective Review of Clinical Trial Safety Data Using Interactive Graphs and Tables

Southworth, Harry

Pages: 199 –215

[Clinical trials collect a great deal of data relating to the safety of the trial participants. The data are complex in nature and traditional approaches to data review involve using summary tables and listed data. An alternative approach to the review of clinical trial safety data is presented,...

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