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MHC Class I Antigens In Malignant Cells

Part of the SpringerBriefs in Cancer Research Book Series (volume 6)

DOI: 10.1007/978-1-4614-6543-0

ISBN: 978-1-4614-6542-3

Publisher: Springer New York - Springer Journals

Jan 30, 2013

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Chapter 1Overview of MHC Class I Antigens

Aptsiauri, Natalia; Garcia-Lora, Angel Miguel; Cabrera, Teresa

Pages: 1 –11

[Cancer development is the result of an accumulation of genetic alterations. Activation or inactivation of certain genes (proto-oncogenes and tumor suppressor genes) is required for cell transformation. As a result of these genetic alterations, tumor cells produce new or modified proteins that...
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Chapter 2HLA Class I Expression in Human Cancer

Aptsiauri, Natalia; Garcia-Lora, Angel Miguel; Cabrera, Teresa

Pages: 13 –30

[Loss or down-regulation of HLA class I antigens in tumor cells has been frequently observed in a variety of human malignancies and it represents an important cancer immune escape mechanism (Garrido et al. 1997a; Marincola et al. 2000; Campoli et al. 2002; Chang et al. 2005; Aptsiauri et al....
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Chapter 3MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns

Aptsiauri, Natalia; Garcia-Lora, Angel Miguel; Cabrera, Teresa

Pages: 31 –45

[In this chapter, we analyze the role of tumor MHC-I cell surface expression in the success of various types of cancer immunotherapy in several mouse models of cancer. First, we show how different immunotherapies influence the growth of MHC-I-positive or -deficient primary tumors. We also...
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Chapter 4Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression

Aptsiauri, Natalia; Garcia-Lora, Angel Miguel; Cabrera, Teresa

Pages: 47 –50

[Based on clinical and experimental evidence it has become clear that low or altered expression of HLA class I molecules on tumor cells are likely to have a negative impact on the outcome of cancer immunotherapy, since it provides malignant cells with a mechanism of immune escape from T cell...
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Chapter 5Conclusions

Aptsiauri, Natalia; Garcia-Lora, Angel Miguel; Cabrera, Teresa

Pages: 51 –51

[Altered MHC Class I expression is a hallmark of malignant transformation and tumor immune escape. Using immunohistochemistry and molecular techniques it has been demonstrated that many types of tumor can lose up to 80 % of normal MHC class I expression. Both reversible and irreversible...

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