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[Cancer development is the result of an accumulation of genetic alterations. Activation or inactivation of certain genes (proto-oncogenes and tumor suppressor genes) is required for cell transformation. As a result of these genetic alterations, tumor cells produce new or modified proteins that...
[Loss or down-regulation of HLA class I antigens in tumor cells has been frequently observed in a variety of human malignancies and it represents an important cancer immune escape mechanism (Garrido et al. 1997a; Marincola et al. 2000; Campoli et al. 2002; Chang et al. 2005; Aptsiauri et al....
[In this chapter, we analyze the role of tumor MHC-I cell surface expression in the success of various types of cancer immunotherapy in several mouse models of cancer. First, we show how different immunotherapies influence the growth of MHC-I-positive or -deficient primary tumors. We also...
[Based on clinical and experimental evidence it has become clear that low or altered expression of HLA class I molecules on tumor cells are likely to have a negative impact on the outcome of cancer immunotherapy, since it provides malignant cells with a mechanism of immune escape from T cell...
[Altered MHC Class I expression is a hallmark of malignant transformation and tumor immune escape. Using immunohistochemistry and molecular techniques it has been demonstrated that many types of tumor can lose up to 80 % of normal MHC class I expression. Both reversible and irreversible...
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