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EBNA1 and Epstein-Barr Virus Associated Tumours

Part of the SpringerBriefs in Cancer Research Book Series (volume 3)

DOI: 10.1007/978-1-4614-6886-8

ISBN: 978-1-4614-6885-1

Publisher: Springer New York - Springer Journals

Apr 2, 2013

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Chapter 1Introduction

Frappier, Lori

Pages: 1 –2

[Epstein-Barr virus (EBV) is a gamma-herpesvirus that infects greater than 90 % of adults worldwide.]
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Chapter 2Roles of EBNA1 at EBV Episomes

Frappier, Lori

Pages: 3 –18

[EBV episomes undergo DNA replication once every cell cycle and therefore resemble the regulated]
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Chapter 3EBNA1-DNA Interactions

Frappier, Lori

Pages: 19 –25

[Soon after EBNA1 was found to be required to replicate and maintain oriP plasmids, EBNA1 was shown to bind to specific sequences in the oriP FR and DS elements through its C-terminal region (Jones et al. 1989; Rawlins et al. 1985). A screen for EBV genomic fragments bound by EBNA1 not only...
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Chapter 4EBNA1 Contributions to EBV-Associated Tumours

Frappier, Lori

Pages: 27 –32

[B cells are the main site of EBV latency and EBV latent infection involves the immortalisation of resting B lymphocytes. Therefore, it is not surprising that most of the tumours associated with EBV infection are B cell lymphomas. Several different types of EBV-associated B cell lymphomas are...
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Chapter 5Cellular Effects of EBNA1

Frappier, Lori

Pages: 33 –42

[EBNA1 functions were initially thought to be restricted to effects on the replication, maintenance and expression of the EBV genome; however, numerous findings in the last decade have identified additional roles for EBNA1 in affecting the cellular environment. Some of these EBNA1 effects may...
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Chapter 6Conclusion

Frappier, Lori

Pages: 43 –43

[There is no doubt that EBNA1 is a central player in EBV infection and EBV-associated tumours.]

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