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Obesity and Breast Cancer

Part of the SpringerBriefs in Cancer Research Book Series

DOI: 10.1007/978-1-4899-8002-1

ISBN: 978-1-4899-8001-4

Publisher: Springer New York - Springer Journals

Nov 22, 2013

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Chapter 1Estrogens, Adiposity and the Menopause

Brown, Kristy A.; Simpson, Evan R.

Pages: 1 –3

[A woman’s reproductive years are characterized by finely tuned waves of circulating sex hormones which are dictated by her menstrual cycle and in turn, influence many, if not all, of her physiological functions. ]
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Chapter 2The Link Between Obesity and Breast Cancer Risk: Epidemiological Evidence

Brown, Kristy A.; Simpson, Evan R.

Pages: 5 –10

[BMI is routinely used to qualify an individual’s adiposity, yet it is simply a measure of an individual’s mass (kg) divided by their height2 (m2). According to the WHO international classification, individuals with a BMI between 18.5 and 24.99 are considered healthy, whereas those with a BMI...
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Chapter 3Adipose-Derived and Obesity-Related Factors and Breast Cancer

Brown, Kristy A.; Simpson, Evan R.

Pages: 11 –15

[It is now clear that the adipose is an important endocrine organ. Considering the vast evidence demonstrating a link between obesity and breast cancer, it is not surprising that attention has turned to the role of factors produced by the adipose, termed adipokines, as major drivers of breast...
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Chapter 4Estrogen Biosynthesis

Brown, Kristy A.; Simpson, Evan R.

Pages: 17 –35

[In the premenopausal woman, the main site of estrogen production is the ovaries, and with every menstrual cycle, rising follicle stimulating hormone levels induce estrogen biosynthesis from granulosa cells of the developing follicles [80]. Estrogens produced from the ovaries act in an endocrine...
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Chapter 5Therapy Aimed at Breaking the Linkage Between Obesity and Breast Cancer

Brown, Kristy A.; Simpson, Evan R.

Pages: 37 –42

[Current endocrine therapy involving aromatase inhibitors is first line therapy for estrogen receptor positive breast cancer. Higher adiposity is associated with higher aromatase expression hence it has been hypothesized that endocrine therapy may not be as effective in overweight and obese...

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