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Mitochondrial Function in Lung Health and Disease

Part of the Respiratory Medicine Book Series (volume 15)

Editors: Natarajan, Viswanathan; Parinandi, Narasimham L.

DOI: 10.1007/978-1-4939-0829-5

ISBN: 978-1-4939-0828-8

Publisher: Springer New York - Springer Journals

Jun 5, 2014

1 - 9 of 9 Chapters

LitStream

Chapter 1Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases

Anantha, Harijith; Kanteti, Prasad; Fu, Panfeng; Kotha, Sainath R.; Parinandi, Narasimham L.; Natarajan, Viswanathan

Pages: 1 –25

[Mitochondria are key cellular organelles that not only supply cellular ATP but also integrate redox signaling, apoptotic balance, and biosynthetic pathways in the cell. Mitochondrial dysfunction leads to loss of cellular function, and in humans, mitochondrial dysfunction causes numerous...
LitStream

Chapter 2Regulation of Mitochondrial Functions by Transcription Factor NRF2

Reddy, Narsa M.; Qureshi, Wajiha; Potteti, Haranath; Kalvakolanu, Dhananjaya V.; Reddy, Sekhar P.

Pages: 27 –50

[Protective and adaptive responses initiated by lung-resident and infiltrated cells play an important role in mitigating the detrimental effects of various toxicants. However, the development of a variety of pulmonary diseases has been attributed to a dysfunctional cellular response following...
LitStream

Chapter 3Mitochondrion: A Missing Link in Asthma Pathogenesis

Mabalirajan, Ulaganathan; Agrawal, Anurag; Ghosh, Balaram

Pages: 51 –70

[Asthma is a multifactorial airway disease with airway hyperresponsiveness, airway inflammation, goblet cell metaplasia, and structural changes including airway smooth muscle proliferation and subepithelial fibrosis. Airway epithelial injury and apoptosis is an important triggering and...
LitStream

Chapter 4ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea

Kumar, Ganesh K.; Raghuraman, Gayatri; Prabhakar, Nanduri R.

Pages: 71 –91

[Obstructive sleep apnea (OSA) associated with recurrent apnea is one of the most commonly encountered breathing disorders in adult humans. Patients with OSA are prone to develop hypertension and cardiovascular diseases. Despite its adverse clinical consequences, the mechanism(s) by which...
LitStream

Chapter 5Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle

Schaible, Niccole; Delmotte, Philippe; Sieck, Gary C.

Pages: 93 –116

[Force generation and contraction of human airway smooth muscle (ASM) involves both an increase in intracellular Ca2 + and an increase in the demand for energy in the form of ATP. Excitation-contraction coupling (ECC) represents a cascade of events that connects the initiating signal, an...
LitStream

Chapter 6Mitochondrial Lipid Peroxidation in Lung Damage and Disease

Kotha, Sainath R.; Gurney, Travis O.; Magalang, Miles U.; Hund, Thomas J.; Satoskar, Abhay R.; Mohler, Peter J.; Maddipati, Krishna Rao; Natarajan, Viswanathan; Parinandi, Narasimham L.

Pages: 117 –139

[Eukaryotic cells possess distinct and double-membrane encapsulated organelles, the mitochondria. The mitochondrion is the powerhouse of the cell responsible for energy production through oxidative phosphorylation. A dark side of the mitochondrion is its ability to generate reactive oxygen...
LitStream

Chapter 7The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung

Kalifa, Lidza; O’Reilly, Michael A.

Pages: 141 –159

[The primary function of the lung is to facilitate the exchange of oxygen and carbon dioxide between air and blood and to exclude or defend against infectious agents and other airborne pollutants. As such, the respiratory epithelium is under constant attack by reactive oxygen species derived from...
LitStream

Chapter 8Mitochondrial Function in Lung Health and Disease

Puente-Maestu, Luis; Chancafe-Morgan, Jorge

Pages: 161 –176

[The mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. In addition to supplying cellular energy, mitochondria are involved in a range of other processes, such as signaling and cell death. The mitochondrion is able to sense PO2 throughout the progressive reduction of...
LitStream

Chapter 9Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage

Tuggle, Katherine L.; Fanucchi, Michelle V.

Pages: 177 –214

[The impact of lung-targeted toxicants on the respiratory system of developing and aging animals is not well defined, let alone the role that mitochondria may play in the cascade of factors involved in cellular injury. Environmentally induced pulmonary cell injury is often due to exposure to...

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