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A Systems Biology Approach to Blood

Part of the Advances in Experimental Medicine and Biology Book Series (volume 844)

Editors: Corey, Seth Joel; Kimmel, Marek; Leonard, Joshua N.

DOI: 10.1007/978-1-4939-2095-2

ISBN: 978-1-4939-2094-5

Publisher: Springer New York - Springer Journals

Dec 6, 2014

1 - 10 of 19 Chapters

LitStream

Systems Hematology: An Introduction

Corey, Seth Joel; Kimmel, Marek; Leonard, Joshua N.

Pages: 3 –10

[Hematologists have traditionally studied blood and its components by simplifying it into its components and functions. A variety of new techniques have generated large and complex datasets. Coupled to an appreciation of blood as a dynamic system, a new approach in systems hematology is needed....
LitStream

Quantification and Modeling of Stem Cell–Niche Interaction

Krinner, Axel; Roeder, Ingo

Pages: 11 –36

[Adult stem cells persist lifelong in the organism, where they are responsible for tissue homeostasis and repair. It is commonly assumed that their maintenance and function are facilitated in local environments called “stem cell niches.” Although there is convincing evidence that a variety of...
LitStream

Erythropoiesis: From Molecular Pathways to System Properties

Koulnis, Miroslav; Porpiglia, Ermelinda; Hidalgo, Daniel; Socolovsky, Merav

Pages: 37 –58

[Erythropoiesis is regulated through a long-range negative feedback loop, whereby tissue hypoxia stimulates erythropoietin (Epo) secretion, which promotes an increase in erythropoietic rate. However, this long-range feedback loop, by itself, cannot account for the observed system properties of...
LitStream

Systems Biology of Megakaryocytes

Kaushansky, Alexis; Kaushansky, Kenneth

Pages: 59 –84

[The molecular pathways that regulate megakaryocyte production have historically been identified through multiple candidate gene approaches. Several transcription factors critical for generating megakaryocytes were identified by promoter analysis of megakaryocyte-specific genes, and their...
LitStream

Systems Biology of Platelet–Vessel Wall Interactions

Chen, Yolande; Corey, Seth Joel; Kim, Oleg V.; Alber, Mark S.

Pages: 85 –98

[Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel’s breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction....
LitStream

Systems Approach to Phagocyte Production and Activation: Neutrophils and Monocytes

Mehta, Hrishikesh M.; Glaubach, Taly; Corey, Seth Joel

Pages: 99 –113

[Granulocyte differentiation and immune response function is a dynamic process governed by a highly coordinated transcriptional program that regulates cellular fate and function, often in a context-dependent manner. Advances in high-throughput technologies and bioinformatics have allowed us to...
LitStream

Stochasticity and Determinism in Models of Hematopoiesis

Kimmel, Marek

Pages: 119 –152

[This chapter represents a novel view of modeling in hematopoiesis, synthesizing both deterministic and stochastic approaches. Whereas the stochastic models work in situations where chance dominates, for example when the number of cells is small, or under random mutations, the deterministic...
LitStream

Systems Analysis of High-Throughput Data

Braun, Rosemary

Pages: 153 –187

[Modern high-throughput assays yield detailed characterizations of the genomic, transcriptomic, and proteomic states of biological samples, enabling us to probe the molecular mechanisms that regulate hematopoiesis or give rise to hematological disorders. At the same time, the high dimensionality...
LitStream

Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control

Siu, Ka Tat; Minella, Alex C.

Pages: 189 –200

[To maintain hematologic homeostasis, hematopoietic stem cells (HSCs) undergo multiple rounds of cell division throughout their lives. Under steady-state conditions, adult HSCs are relatively quiescent and reside primarily in hypoxic bone marrow niches. In response to physiologic stimuli, normal...
LitStream

A Systems Biology Approach to Iron Metabolism

Chifman, Julia; Laubenbacher, Reinhard; Torti, Suzy V.

Pages: 201 –225

[Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the...

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