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Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1168)

Editors: Ruiz-Garcia, Erika; Astudillo-de la Vega, Horacio

DOI: 10.1007/978-3-030-24100-1

ISBN: 978-3-030-24099-8

Publisher: Springer International Publishing - Springer Journals

Nov 12, 2019

1 - 10 of 11 Chapters

LitStream

Chapter 1Pharmaco-Geno-Proteo-Metabolomics and Translational Research in Cancer

Fernández-Figueroa, Edith A.; Lino-Silva, Saul; Peña-Velasco, Jorge E.; Rangel-Escareño, Claudia

Pages: 1 –7

[The diagnosis, prognosis and treatment of cancer has had a great improvement due to the “omics” technologies such as genomics, proteomics, epigenomics, pharmacogenomics, and metabolomics. The technological progress of these technologies has allowed precision medicine to become a clinical...
LitStream

Chapter 2Next Generation Sequencing (NGS): A Revolutionary Technology in Pharmacogenomics and Personalized Medicine in Cancer

Morganti, Stefania; Tarantino, Paolo; Ferraro, Emanuela; D’Amico, Paolo; Duso, Bruno Achutti; Curigliano, Giuseppe

Pages: 9 –30

[Following the completion of the Human Genome Project in 2003, research in oncology has progressively focused on the sequencing of cancer genomes, with the aim of better understanding the genetic basis of oncogenesis and identifying actionable alterations. The development of...
LitStream

Chapter 3Pharmaco-epigenomics: On the Road of Translation Medicine

López-Camarillo, César; Gallardo-Rincón, Dolores; Álvarez-Sánchez, María Elizbeth; Marchat, Laurence A.

Pages: 31 –42

[Epigenomics refers to the study of genome-wide changes in epigenetic mechanisms including DNA methylation, histone modifications and non-coding RNAs expression. The alterations in normal DNA methylation and histone acetylation/deacetylation patterns lead to deregulated transcription and...
LitStream

Chapter 4Design and Implementing Pharmacogenomics Study in Cancer

Romero Lagunes, María Luisa; Vera Badillo, Francisco Emilio

Pages: 43 –77

[The advances in technology has shifted healthcare from a “one size fits all” model to focus on personalized therapy. Understanding the relationship of genome variations and its effect on drug response has led to individualized drug selection, maximizing drug efficacy and improving toxicity...
LitStream

Chapter 5Onco-omics Approaches and Applications in Clinical Trials for Cancer Patients

Hernandez-Martinez, Juan-Manuel; Sánchez-Reyes, Roberto; De la Garza-Salazar, J. G.; Arrieta, Oscar

Pages: 79 –90

[Omics technologies have revolutionised fundamental and medical research. Oncology is perhaps the field where these technologies have been most rapidly adopted and where they have had their biggest impact, dramatically transforming clinical practice guidelines over a very short period of time....
LitStream

Chapter 6Issues and Ethical Considerations in Pharmaco-oncogenomics

Morgan, Gilberto

Pages: 91 –101

[The rapid advancements of treatment modalities and vast amounts of information being generated through novel technologies, paint the picture of a very promising future, one that will allow for a more efficient and precise DNA sequencing and potentially more tailored cancer therapies for...
LitStream

Chapter 7Pharma-Oncogenomics in the Era of Personal Genomics: A Quick Guide to Online Resources and Tools

Joshi, Rohan P.; Steiner, David F.; Konnick, Eric Q.; Suarez, Carlos J.

Pages: 103 –115

[The past two decades have seen unprecedented advances in the field of oncogenomics. The ongoing characterization of neoplastic tissues through genomic techniques has transformed many aspects of cancer research, diagnosis, and treatment. However, identifying sequence variants with biological and...
LitStream

Chapter 8Immuno-Oncology in the Era of Personalized Medicine

Gwin, William R.; Disis, Mary L.; Ruiz-Garcia, Erika

Pages: 117 –129

[Personalized medicine in oncology utilizes evidence derived from genetic, immune, and proteomic profiling to inform therapeutic options as well as provide prognostic information for each unique individual and their tumor. Our ability to biologically and immunologically define each patient’s...
LitStream

Chapter 9CAR-T cell and Personalized Medicine

Cruz-Ramos, Marlid; García-Foncillas, Jesús

Pages: 131 –145

[Adoptive T cell transfer (ACT) is a new era for cancer treatment, involving infusion of autologous lymphocytes. Chimeric antigen receptors (CAR) on the surface of T cells are emerging as a novel therapeutic that is giving other direction to T-cell specificity and precision medicine. T cells are...
LitStream

Chapter 10Oncobiome at the Forefront of a Novel Molecular Mechanism to Understand the Microbiome and Cancer

Astudillo-de la Vega, H.; Alonso-Luna, O.; Ali-Pérez, J.; López-Camarillo, C.; Ruiz-Garcia, E.

Pages: 147 –156

[The microbiome comprises all the genetic material within a microbiota, that represents tenfold higher than that of our cells. The microbiota it includes a wide variety of microorganisms such as bacteria, viruses, protozoans, fungi, and archaea, and this ecosystem is personalized in any body...

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