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Reviews on Biomarker Studies in Aging and Anti-Aging Research

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1178)

Editors: Guest, Paul C.

DOI: 10.1007/978-3-030-25650-0

ISBN: 978-3-030-25649-4

Publisher: Springer International Publishing - Springer Journals

Sep 7, 2019

1 - 10 of 13 Chapters

LitStream

Chapter 1Of Mice, Whales, Jellyfish and Men: In Pursuit of Increased Longevity

Guest, Paul C.

Pages: 1 –24

[The quest for increased human longevity has been a goal of mankind throughout recorded history. Recent molecular studies are now providing potentially useful insights into the aging process which may help to achieve at least some aspects of this quest. This chapter will summarize the main...
LitStream

Chapter 2Effects on Glial Cell Glycolysis in Schizophrenia: An Advanced Aging Phenotype?

Zuccoli, Giuliana S.; Guest, Paul C.; Martins-de-Souza, Daniel

Pages: 25 –38

[Schizophrenia is a severe and debilitating psychiatric disorder believed to have neurodevelopmental origins. Several studies have associated energy metabolism dysfunction with the disorder, mostly related to glycolysis alterations. Glucose is the obligatory energy substrate of the brain and...
LitStream

Chapter 3Aging Biomarkers and Novel Targets for Anti-Aging Interventions

Xu, Kang; Guo, Yannan; Li, Zhongchi; Wang, Zhao

Pages: 39 –56

[The aging population worldwide is expanding at an increasing rate. By 2050, approximately a quarter of the world population will consist of the elderly. To slow down the aging process, exploration of aging biomarkers and the search for novel antiaging targets have attracted much interest....
LitStream

Chapter 4Sex Differences in Aging and Associated Biomarkers

Thomas, Natalie; Gurvich, Caroline; Kulkarni, Jayashri

Pages: 57 –76

[Aging is a natural process defined by the gradual, time-dependent decline of biological and behavioural functions, for which individuals of the same chronological age show variability. The capacity of biological systems to continuously adjust for optimal functioning despite ever changing...
LitStream

Chapter 5The Therapeutic Potential of Ketogenic Diet Throughout Life: Focus on Metabolic, Neurodevelopmental and Neurodegenerative Disorders

Kraeuter, Ann-Katrin; Guest, Paul C.; Sarnyai, Zoltan

Pages: 77 –101

[This chapter reviews the efficacy of the ketogenic diet in a variety of neurodegenerative, neurodevelopmental and metabolic conditions throughout different stages of life. It describes conditions affecting children, metabolic disorders in adults and disorderrs affecting the elderly. We have...
LitStream

Chapter 6Coenzyme Q10 Supplementation in Fibrosis and Aging

Hargreaves, Iain P.; Mantle, David

Pages: 103 –112

[Coenzyme Q10 (CoQ10) is a vitamin-like substance which functions as an electron carrier within the mitochondrial respiratory chain, as well as serving as an important intracellular antioxidant. Most of the body’s CoQ10 requirements are met by endogenous synthesis, although the capacity for CoQ10...
LitStream

Chapter 7Dietary Restriction, Cardiovascular Aging and Age-Related Cardiovascular Diseases: A Review of the Evidence

Abiri, Behnaz; Vafa, Mohammadreza

Pages: 113 –127

[Both morbidity and mortality due to cardiovascular diseases (CVDs) elevate with age. The elevated prevalence of cardiovascular risk factors with age and cardiovascular aging contribute to the relationship between aging and CVDs. Dietary restriction (DR) consisting of calorie restriction (CR) and...
LitStream

Chapter 8Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging

Ticinesi, Andrea; Nouvenne, Antonio; Tana, Claudio; Prati, Beatrice; Meschi, Tiziana

Pages: 129 –154

[Gut microbiota composition and functionality can influence the pathophysiology of age-related cognitive impairment and dementia, according to a large number of animal studies. The translation of this concept to humans is still uncertain, due to the relatively low number of clinical studies...
LitStream

Chapter 9The Impact of Herbal Products in the Prevention, Regeneration and Delay of Skin Aging

Warsito, Mega Ferdina; Kusumawati, Idha

Pages: 155 –174

[Skin aging is a complex process induced by intrinsic and extrinsic factors and causes alterations to the structural and functional aspects of the skin. Skin aging affects patients physically and physiologically. Understanding the process of skin aging can provide new knowledge on how to...
LitStream

Chapter 10Epigenetic Clock: Just a Convenient Marker or an Active Driver of Aging?

Ashapkin, Vasily V.; Kutueva, Lyudmila I.; Vanyushin, Boris F.

Pages: 175 –206

[A global DNA hypomethylation and local changes in the methylation levels of specific DNA loci occur during aging in mammals. Global hypomethylation mainly affects highly methylated repeat sequences, such as transposable elements; it is an essentially stochastic process usually referred to as...

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