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Reviews on New Drug Targets in Age-Related Disorders

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1286)

Editors: Guest, Paul C.

DOI: 10.1007/978-3-030-55035-6

ISBN: 978-3-030-55034-9

Publisher: Springer International Publishing - Springer Journals

Mar 17, 2021

1 - 10 of 17 Chapters

LitStream

Chapter 1New Therapeutic Approaches and Biomarkers for Increased Healthspan

Guest, Paul C.

Pages: 1 –13

[Healthcare costs have increased in developing countries over the last few decades, mostly due to the escalation in average life expectancy and the concomitant increase in age-related disorders. To address this issue, widespread research is now being undertaken across the globe with the aim of...
LitStream

Chapter 2Targeting Cancer Metabolism and Current Anti-Cancer Drugs

Sukjoi, Witchuda; Ngamkham, Jarunya; Attwood, Paul V.; Jitrapakdee, Sarawut

Pages: 15 –48

[Several studies have exploited the metabolic hallmarks that distinguish between normal and cancer cells, aiming at identifying specific targets of anti-cancer drugs. It has become apparent that metabolic flexibility allows cancer cells to survive during high anabolic demand or the depletion of...
LitStream

Chapter 3A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer

Panahi, Yunes; Mohammadzadeh, Amir Hossein; Behnam, Behzad; Orafai, Hossein M.; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Pages: 49 –64

[Non-small cell lung cancer (NSCLC) is one of the most common types of lung cancer worldwide. It metastasizes rapidly and has a poor prognosis. The first-line treatment for most patients is a combination of chemotherapy and radiation. In many subjects, using targeted treatments alongside...
LitStream

Chapter 4Parkinson’s Disease and Impairment in Mitochondrial Metabolism: A Pathognomic Signature

Das, Biswadeep; Dash, Sriya Priyadarshini; Mohanty, Swabhiman; Patel, Paritosh

Pages: 65 –76

[Mitochondrial bioenergetics is vital for the proper functioning of cellular compartments. Impairments in mitochondrial DNA encoding the respiratory chain complexes and other assisting proteins, accumulation of intracellular reactive oxygen species, an imbalance in cellular calcium transport, or...
LitStream

Chapter 5Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q10

Hargreaves, Iain P.; Mantle, David

Pages: 77 –85

[Fibromyalgia is a common chronic pain condition of unknown aetiology, although mitochondrial dysfunction, oxidative stress, and inflammation have been implicated in the pathophysiology of this disorder. Treatment generally involves physiotherapy, anticonvulsants, and antidepressant therapy;...
LitStream

Chapter 6Immunoregulatory Effects of Tolerogenic Probiotics in Multiple Sclerosis

Atabati, Hadi; Yazdanpanah, Esmaeil; Mortazavi, Hamed; bajestani, Saeed Gharibian; Raoofi, Amir; Esmaeili, Seyed-Alireza; Khaledi, Azad; Saburi, Ehsan; Afshari, Jalil Tavakol; Sathyapalan, Thozhukat; Moghaddam, Abbas Shapouri; Sahebkar, Amirhossein

Pages: 87 –105

[Gut microbiota has essential roles in the prevention and progression of multiple sclerosis (MS). The association between the gut microbiota and the central nervous system (CNS) or immune system response of MS patients has been documented in many studies. The composition of the gut microbiota...
LitStream

Chapter 7Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer

Duncan, Leslie; Shay, Chloe; Teng, Yong

Pages: 107 –114

[The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological...
LitStream

Chapter 8A Systematic Review on the Genotoxic Effects of Selective Serotonin Reuptake Inhibitors

Ahmadimanesh, Mahnaz; Abbaszadegan, Mohammad Reza; Hedayati, Narges; Yazdian-Robati, Rezvan; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Pages: 115 –124

[Depression is a mental disorder and a major public health concern affecting millions of people worldwide. It is a common disorder that has been associated with several medical comorbidities often linked with aging, such as dementia, type II diabetes, cardiovascular and cerebrovascular diseases,...
LitStream

Chapter 9Toward a New Era for the Management of Circulating Tumor Cells

Galvis, Marisol Miranda; Romero, Celeste Sánchez; Bueno, Thiago Oliveira; Teng, Yong

Pages: 125 –134

[Circulating tumor cells (CTCs) are malignant cells separate from primary tumors, which can migrate through the peripheral blood, colonize other tissues, and lead to the formation of metastases. The first description of CTCs dates back to 1869 when Thomas Ashworth recognized malignant cells...
LitStream

Chapter 10Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer

Forouzanfar, Fatemeh; Majeed, Muhammed; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Pages: 135 –143

[Telomerases are attractive targets for development of new anticancer agents. Most tumors express the enzyme telomerase that maintains telomere length and thus ensures indefinite cell proliferation, a hallmark of cancer. Curcumin has been shown to be effective against several types of...

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