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Cell Biology and Translational Medicine, Volume 12

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1326)

Editors: Turksen, Kursad

DOI: 10.1007/978-3-030-71933-3

ISBN: 978-3-030-71932-6

Publisher: Springer International Publishing - Springer Journals

Jan 1, 2021

1 - 10 of 10 Chapters

LitStream

Chapter 608Immune Dysregulation and Recurring Mutations in Myelodysplastic Syndromes Pathogenesis

Matos, Anacélia; Magalhães, Silvia M. M.; Rauh, Michael J.

Pages: 1 –10

[Myelodysplastic syndromes (MDS) are clonal stem cell malignancies characterized by ineffective hematopoiesis leading to peripheral cytopenias and variable risk of progression to acute myeloid leukemia. Inflammation is associated with MDS pathogenesis. Several cytokines, reactive species of...
LitStream

Chapter 577Stem Cell Aging and Regenerative Medicine

De, Debojyoti; Karmakar, Parimal; Bhattacharya, Debalina

Pages: 11 –37

[Stem cells are a promising source for regenerative medicine to cure a plethora of diseases that are currently treated based on either palliative or symptomatic relief or by preventing their onset and progression. Aging-associated degenerative changes in stem cells, stem cell niches, and...
LitStream

Chapter 606Potential of Chimeric Antigen Receptor T-Cells in Cancer Therapy

Desai, Drashti; Gaud, R. S.; Shende, Pravin

Pages: 39 –46

[Novel approaches for targeted delivery like nanoparticles, liposomes, polymer conjugates, etc. with better safety profile needs to be developed for cancer treatment. Chimeric antigen receptors (CAR) with modified thymus cells (T-cells) showed greater potential as a therapy due to its direct...
LitStream

Chapter 622Drug Sensitivity and Drug Repurposing Platform for Cancer Precision Medicine

Nweke, Ekene Emmanuel; Thimiri Govinda Raj, Deepak B.

Pages: 47 –53

[One of the critical Global challenges in achieving the UN Sustainable Development Goals 3 Good Health and Well Being is optimizing drug discovery and translational research for unmet medical need in both communicable and non-communicable diseases. Recently, the WHO reports there has been a shift...
LitStream

Chapter 607Role and Regulation of Lin28 in Progenitor Cells During Central Nervous System Development

Faunes, Fernando

Pages: 55 –72

[Lin28 is a highly conserved RNA binding protein that regulates stemness whose molecular role has been widely studied in vitro. However, the regulation and the molecular role of Lin28 during the development of the vertebrate central nervous system (CNS) in vivo are not completely understood....
LitStream

Chapter 625Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives

Taghiyar, Leila; Jahangir, Shahrbano; Khozaei Ravari, Mojtaba; Shamekhi, Mohammad Amin; Eslaminejad, Mohamadreza Baghaban

Pages: 73 –93

[Osteoarthritis (OA) and other degenerative joint diseases are characterized by articular cartilage destruction, synovial inflammation, sclerosis of subchondral bone, and loss of extracellular matrix (ECM). Worldwide, these diseases are major causes of disability. Cell therapies have been...
LitStream

Chapter 603Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin

Catalán, Mabel; Rodríguez, Catalina; Olmedo, Ivonne; Carrasco-Rojas, Javiera; Rojas, Diego; Molina-Berríos, Alfredo; Díaz-Dosque, Mario; Jara, José A.

Pages: 95 –109
LitStream

Chapter 612A Comprehensive Approach to Urticaria: From Clinical Presentation to Modern Biological Treatments Through Pathogenesis

Folci, Marco; Ramponi, Giacomo; Brunetta, Enrico

Pages: 111 –137

[Urticaria is characterized by the cutaneous presence of wheals (hives), angioedema or both. Acute and chronic urticaria are distinguished based on a duration of less or more than 6 weeks. Chronic urticaria can be further classified into a spontaneous form and several inducible types triggered by...
LitStream

Chapter 619The Potentials and Pitfalls of Using Adult Stem Cells in Cancer Treatment

Das, Mrinal K.; Lunavat, Taral R.; Miletic, Hrvoje; Hossain, Jubayer A.

Pages: 139 –157

[Stem cells play a pivotal role in the developmental stages of an organism and in adulthood as well. Therefore, it is not surprising that stem cells constitute a focus of extensive research. Indeed, several decades of stem cell research have tremendously increased our knowledge on the mechanistic...
LitStream

Chapter 581The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis

Roudsari, Peyvand Parhizkar; Alavi-Moghadam, Sepideh; Rezaei-Tavirani, Mostafa; Goodarzi, Parisa; Tayanloo-Beik, Akram; Sayahpour, Forough Azam; Larijani, Bagher; Arjmand, Babak

Pages: 159 –186

[Rheumatoid arthritis as a common autoimmune inflammatory disorder with unknown etiology can affect 0.5–1% of adults in developed countries. It involves more than just the patient’s joints and can be accompanied by several comorbidities and affect cardiovascular, pulmonary, and some other systems...

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