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Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1394)

Editors: Rezaei, Nima; Hanaei, Sara

DOI: 10.1007/978-3-031-14732-6

ISBN: 978-3-031-14731-9

Publisher: Springer International Publishing - Springer Journals

Jan 2, 2023

1 - 10 of 13 Chapters

LitStream

Chapter 1Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction

Iranmehr, Arad; Namvar, Mohamad; Rezaei, Nima; Hanaei, Sara

Pages: 1 –18

[As one of the global concerns, cancers, including brainBrainand spinal cord tumorsSpinal cord tumors, are responsible for mortalities and irreversible morbidities in the affected patients. Although advancements in molecular pathology and imaging of tumors may have influenced the...
LitStream

Chapter 2The Epidemiology of Brain and Spinal Cord Tumors

Shobeiri, Parnian; Seyedmirzaei, Homa; Kalantari, Amirali; Mohammadi, Esmaeil; Rezaei, Nima; Hanaei, Sara

Pages: 19 –39

[CNS tumors are a diverse group of neoplasmsNeoplasm that emerge from a variety of different CNSCentral Nervous System (CNS) cell types. These tumors may be benignBenign, malignantMalignant, or borderline in nature. The majority of high grade glial tumors are fatal, with the exception of...
LitStream

Chapter 3The Role of Neuro-Inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors

Casili, Giovanna; Paterniti, Irene; Campolo, Michela; Esposito, Emanuela; Cuzzocrea, Salvatore

Pages: 41 –49

[InflammationInflammationand innate immune systemInnate immune system play a central role in cancers, including those affecting the central nervous systemCentral Nervous System (CNS) (CNS). Currently, classification of neoplasmsNeoplasm, especially regarding gliomas, is established on molecular...
LitStream

Chapter 4The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors

Tay, Angelique Sao-Mai S.; Black, Keith L.; Yu, John S.

Pages: 51 –72

[Major advances have been made in our understanding of CNSCentral Nervous System (CNS) tumors, especially glioma, however, the survivalSurvival of patients with malignantMalignant glioma remains poor. While radiation and chemotherapyChemotherapy have increased overall survivalOverall survival,...
LitStream

Chapter 5Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors

Medikonda, Ravi; Pant, Ayush; Lim, Michael

Pages: 73 –84

[Historically, the central nervous systemCentral Nervous System (CNS) (CNS) was considered an immune-privileged organ. However, recent studies have shown that the immune systemImmune system plays a significant role in the CNSCentral Nervous System (CNS). Thus, there is renewed interest in...
LitStream

Chapter 6Cell of Origin of Brain and Spinal Cord Tumors

Laurenge, Alice; Huillard, Emmanuelle; Bielle, Franck; Idbaih, Ahmed

Pages: 85 –101

[A better understanding of cellular and molecular biologyBiologyof primary central nervous systemCentral Nervous System (CNS) (CNS) tumors is a critical step toward the design of innovative treatments. In addition to improving knowledge, identification of the cell of originCell of origin in...
LitStream

Chapter 7The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasm

Verma, Pooja; Shanker, Ravi; Patel, Vinal; Bhattacharya, Mahua

Pages: 103 –117

[This chapter focuses on the division and location of brainBrain deformities such as tumors in magnetic resonance imaging (MRI)Magnetic Resonance Imaging (MRI)through Chan-VeseChan-Veseactive contour segmentationActive contour segmentation. Brain tumorBrain tumor division and identification is a...
LitStream

Chapter 8The Role of Epigenetics in Brain and Spinal Cord Tumors

Park, Sung-Hye

Pages: 119 –136

[Identification of distinct genetic and epigeneticEpigenetic profiles in various neuroepithelial tumorsNeuroepithelial tumors has improved the classification and uncovered novel diagnostic, prognostic, and predictive molecular biomarkers for improved prediction of treatment response and outcome....
LitStream

Chapter 9Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors

Pour-Rashidi, Ahmad; Mohammadi, Esmaeil; Rezaei, Nima; Hanaei, Sara

Pages: 137 –152

[The CNS tumors, in particular those with malignantMalignant characteristics, are prominent burdens around the world with high mortalityMortality and low cure rate. Given that, researchers were curious about novel treatments with promising effectiveness which resulted in shifting the dogmatism...
LitStream

Chapter 10Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors

Sadeghmousavi, Shaghayegh; Rezaei, Nima; Hanaei, Sara

Pages: 153 –180

[Brain tumorBrain tumor (BT) is the second most common pediatric cancer, one of the most common cancers among adults, and the major cause of cancer-related morbidityMorbidityand mortalityMortality worldwide. Both genetics and environment can contribute to BT induction. One of the environmental...

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