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Iron Acquisition by the Genus Mycobacterium

Part of the SpringerBriefs in Molecular Science Book Series

Editors: Byers, B. Rowe

DOI: 10.1007/978-3-319-00303-0

ISBN: 978-3-319-00302-3

Publisher: Springer International Publishing - Springer Journals

May 18, 2013

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Chapter 1Introduction to the Book

Byers, B. Rowe

Pages: 1 –2

[Astronomers tell us that all stars are furnaces fueled by fusion of hydrogen into helium. When their fuel is spent, the central cores of stars collapse, reaching 100 million degrees Kelvin. Under these conditions nuclei fuse to form heavier elements, such as carbon, oxygen, and eventually iron....
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Chapter 2A History of Iron Metabolism in the Mycobacteria

Ratledge, Colin

Pages: 3 –39

[The importance of iron to the metabolism of the mycobacteria was gradually appreciated during the first half of the last century. Frank Winder working in Dublin in the 1950s and 1960s was the first to establish the absolute amounts of iron needed for growth and, from his work, it was then...
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Chapter 3Mycobacterial Iron Acquisition Mechanisms

Byers, B. Rowe

Pages: 41 –52

[In both pathogenic and saprophytic mycobacteria, many of the genes and systems required for high affinity iron acquisition have been identified, including siderophore production, uptake of ferric-siderophores, production of iron storage proteins, and uptake of heme. Production and function of...
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Chapter 4Siderocalin Combats Mycobacterial Infections

Allred, Benjamin E.; Sia, Allyson K.; Raymond, Kenneth N.

Pages: 53 –64

[The human immunoprotein siderocalin (Scn) protects against infections by binding the siderophores used by a pathogen to steal iron from host iron stores, thereby limiting bacterial growth and subsequent colonization by restricting the supply of iron. Mycobacterium tuberculosis synthesizes two...
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Chapter 5Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis

Juárez-Hernández, Raúl E.; Zhu, Helen; Miller, Marvin J.

Pages: 65 –88

[This chapter reviews recent pertinent literature on the Mycobacterium tuberculosis siderophore mycobactin and its excreted counterpart carboxymycobactin. Emphasis is placed on the design of antibiotics to specifically interfere with the biosynthesis of these siderophores and the use of...

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