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miRNAs and Target Genes in Breast Cancer Metastasis

Part of the SpringerBriefs in Cancer Research Book Series

DOI: 10.1007/978-3-319-08162-5

ISBN: 978-3-319-08161-8

Publisher: Springer International Publishing - Springer Journals

Sep 6, 2014

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Chapter 1Introduction: Role of miRNAs and Their Target Genes in Breast Cancer Metastasis

Sethi, Seema; Ali, Shadan; Sarkar, Fazlul H.

Pages: 1 –6

[Breast cancer is the most common cancer among women in the United States and the second leading cause of cancer deaths among women of all ages [1]. In 2013, there have been approximately 232,340 new cases of invasive breast cancer and 39,620 breast cancer deaths among US women [2]. One out of 8...
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Chapter 2Molecular Pathogenesis of Breast Cancer and the Role of MicroRNAs

Ali, Shadan; Sethi, Seema; Ali, Azfur S.; Philip, Philip A.; Sarkar, Fazlul H.

Pages: 7 –22

[Breast cancer is a leading cause of cancer-associated death in women worldwide. The therapy usually involves mastectomy or lumpectomy, followed by chemotherapy and/or radiation therapy in addition to hormonal therapy when indicated. While the area of research on the identification and potential...
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Chapter 3Epidemiology, Risk Factors, Treatment, and Prevention of Breast Cancer Metastases

Nizam, Manal; Haq, Saba; Ali, Shadan; Suresh, Raagini; Mohammad, Ramzi M.; Sarkar, Fazlul H.

Pages: 23 –35

[A large percentage of Americans are plagued by cancer. In the United States, one third of females and one half of males face the condition sometime in their lifetime. One type of cancer that has adversely impacted the lives of many on a multinational scale is breast cancer (BC). In order to...
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Chapter 4Clinical Perspectives: Breast Cancer Brain Metastasis

Michelhaugh, Sharon K.; Bollig-Fischer, Aliccia; Mittal, Sandeep

Pages: 37 –51

[The incidence of central nervous system metastasis from primary breast cancer has steadily increased with aggressive chemotherapy resulting in improved long-term survival. Brain metastases are more common among those with more aggressive histological subtypes of breast cancer such as triple...
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Chapter 5Clinical Perspectives: Breast Cancer Bone Metastasis

Kadado, Allen; Sethi, Anil; Vaidya, Rahul

Pages: 53 –64

[Bone metastasis of breast cancer denotes progression of the disease process resulting in increased morbidity and a decrease in quality of life. Early diagnosis and treatment may help minimize pain and improve function. Metastatic lesions from the breast are commonly osteolytic but may be...
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Chapter 6Molecular Targeted Therapy for Brain Metastatic Breast Cancers: Current Updates

Ahmad, Aamir; Sarkar, Fazlul H.

Pages: 65 –75

[Metastatic breast cancers are difficult to manage, and brain metastatic breast cancers are particularly lethal with poor overall survival and outcomes. Our understanding of factors that facilitate brain metastasis of breast cancers is very poor. However, a number of studies in the last few years...

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