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Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

Part of the Advances in Experimental Medicine and Biology Book Series (volume 890)

Editors: Ahmad, Aamir; Gadgeel, Shirish M.

DOI: 10.1007/978-3-319-24932-2

ISBN: 978-3-319-24931-5

Publisher: Springer International Publishing - Springer Journals

Dec 25, 2015

1 - 10 of 11 Chapters

LitStream

Chapter 1Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development

Wijesinghe, Priyanga; Bollig-Fischer, Aliccia

Pages: 1 –23

[Lung cancer is the leading cause of cancer-related deaths in the United States and the 5-year overall survival outlook for a patient has not improved in several decades. Recently, however, molecular and genomic profiling of the lung tumors has revealed recurring somatic mutations. As a result...
LitStream

Chapter 2Emerging Biomarkers in Personalized Therapy of Lung Cancer

Cagle, Philip T.; Raparia, Kirtee; Portier, Bryce P.

Pages: 25 –36

[The two clinically validated and Food and Drug Administration approved lung cancer predictive biomarkers (epidermal growth factor receptor mutations and anaplastic lymphoma kinase (ALK) translocations) occur in only about 20 % of lung adenocarcinomas and acquired resistance develops to first...
LitStream

Chapter 3Epithelial Mesenchymal Transition in Aggressive Lung Cancers

Mittal, Vivek

Pages: 37 –56

[The progression of a cancer cell into a metastatic entity contributes to more than 90 % of cancer related deaths. Therefore, the prevention and treatment of metastasis is an unmet clinical need. Epithelial to mesenchymal transition (EMT) is an evolutionary conserved developmental program, which...
LitStream

Chapter 4The Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer

Suresh, Raagini; Ali, Shadan; Ahmad, Aamir; Philip, Philip A.; Sarkar, Fazlul H.

Pages: 57 –74

[Lung cancer is the leading cause of cancer-related deaths worldwide with a 5-year overall survival rate of less than 20 %. Considering the treatments currently available, this statistics is shocking. A possible explanation for the disconnect between sophisticated treatments and the survival rate...
LitStream

Chapter 5The Microenvironment of Lung Cancer and Therapeutic Implications

Mittal, Vivek; El Rayes, Tina; Narula, Navneet; McGraw, Timothy E.; Altorki, Nasser K; Barcellos-Hoff, Mary Helen

Pages: 75 –110

[The tumor microenvironment (TME) represents a milieu that enables tumor cells to acquire the hallmarks of cancer. The TME is heterogeneous in composition and consists of cellular components, growth factors, proteases, and extracellular matrix. Concerted interactions between genetically altered...
LitStream

Chapter 6Epigenetics in Personalized Management of Lung Cancer

Ahmad, Aamir

Pages: 111 –122

[In last several years, the focus on the origin and progression of human cancers has shifted from genetic to epigenetic regulation, with particular attention to methylation and acetylation events that have profound effect on the eventual expression of oncogenes and the suppression of tumor...
LitStream

Chapter 7Next-Generation Sequencing and Applications to the Diagnosis and Treatment of Lung Cancer

Kruglyak, Kristina M.; Lin, Erick; Ong, Frank S.

Pages: 123 –136

[Cancer is a genetic disease characterized by uncontrolled growth of abnormal cells. Over time, somatic mutations accumulate in the cells of an individual due to replication errors, chromosome segregation errors, or DNA damage. When not caught by traditional mechanisms, these somatic mutations...
LitStream

Chapter 8Nanomedicine for Treatment of Lung Cancer

Hussain, Sajid

Pages: 137 –147

[Lung cancer is the second most common cancer and the primary cause of cancer-related death in both men and women in the United States and rest of the world. Due to diagnosis at an advanced stage, it is associated with a high mortality in a majority of patients. In recent years, enormous advances...
LitStream

Chapter 9Personalized Therapy of Small Cell Lung Cancer

Schneider, Bryan J.; Kalemkerian, Gregory P.

Pages: 149 –174

[Small cell lung cancer (SCLC) is an aggressive, poorly differentiated neuroendocrine carcinoma with distinct clinical, pathological and molecular characteristics. Despite robust responses to initial chemotherapy and radiation, the prognosis of patients with SCLC remains poor with an overall...
LitStream

Chapter 10Personalized Radiation Therapy (PRT) for Lung Cancer

Jin, Jian-Yue; Kong, Feng-Ming (Spring)

Pages: 175 –202

[This chapter reviews and discusses approaches and strategies of personalized radiation therapy (PRT) for lung cancers at four different levels: (1) clinically established PRT based on a patient’s histology, stage, tumor volume and tumor locations; (2) personalized adaptive radiation therapy (RT)...

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