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Systems Biology of Tumor Physiology

Part of the SpringerBriefs in Cancer Research Book Series

DOI: 10.1007/978-3-319-25601-6

ISBN: 978-3-319-25599-6

Publisher: Springer International Publishing - Springer Journals

Dec 12, 2015

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Chapter 1Macrophages, Extracellular Matrix, and Estrogens in Breast Cancer Risk

Nguyen, David H.

Pages: 1 –19

[The primary purpose of this chapter is to succinctly present evidence that macrophages are one of the important components within the complex mechanism underlying why lifelong exposure to estrogen is a risk factor for breast cancer. In line with the systems biology theme of this book, this...
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Chapter 2Cellular Plasticity, Cancer Stem Cells, and Cells-of-Origin

Nguyen, David H.

Pages: 21 –31

[It is now recognized that tumor cells share similarities to stem cells in that they do not have a strong sense of functional identity. In the case of the skin, a mature cell that becomes stem-like no longer has the identity of a skin cell, meaning it changes shape and behaves in ways that make...
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Chapter 3Using Mouse Models and Making Sense of Them

Nguyen, David H.

Pages: 33 –54

[The purpose of this chapter is to provide some insights into the use and misuse of mouse models of cancer. The goal is that this chapter will help investigators better plan their mouse experiments. It also will be helpful in making sense of data that is conflicting or incongruous across...

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