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Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract

Part of the Advances in Experimental Medicine and Biology Book Series (volume 908)

Editors: Jansen, Marnix; Wright, Nicholas A.

DOI: 10.1007/978-3-319-41388-4

ISBN: 978-3-319-41386-0

Publisher: Springer International Publishing - Springer Journals

Aug 30, 2016

1 - 10 of 23 Chapters

LitStream

Chapter 1Distal Esophageal Adenocarcinoma and Gastric Adenocarcinoma: Time for a Shared Research Agenda

Jansen, Marnix; Wright, Nicholas A.

Pages: 1 –8

[The key insight that sparked Darwin’s theory of descent with modification was that he compared and contrasted differences between living and extinct species across time and space. He likely arrived on this theory in large part through his culinary experiences, set against the background of the...
LitStream

Clonal Evolution of Stem Cells in the Gastrointestinal Tract

Fink, Juergen; Koo, Bon-Kyoung

Pages: 11 –25

[The field of gastrointestinal epithelial stem cells is a rapidly developing area of adult stem cell research. The discovery of Lgr5+ intestinal stem cells has enabled us to study many hidden aspects of the biology of gastrointestinal adult stem cells. Marked by Lgr5 and Troy, several novel...
LitStream

The Complex, Clonal, and Controversial Nature of Barrett’s Esophagus

Evans, James A.; McDonald, Stuart A. C.

Pages: 27 –40

[Barrett’s esophagus (BO) is a preneoplastic condition described as the replacement of the stratified squamous epithelium of the distal esophagus with one that histologically presents as a diverse mixture of metaplastic glands resembling gastric or intestinal-type columnar epithelium. The clonal...
LitStream

A New Pathologic Assessment of Gastroesophageal Reflux Disease: The Squamo-Oxyntic Gap

Chandrasoma, Parakrama; DeMeester, Tom

Pages: 41 –78

[Diagnosis of gastroesophageal reflux disease (GORD) is delayed by the lack of uniform histopathologic criteria for diagnosis. The only practical value of pathology is the assessment of columnar lined esophagus (CLO). As a result, GORD is treated with acid suppressive drug therapy until there is...
LitStream

Diagnosis by Endoscopy and Advanced Imaging of Barrett’s Neoplasia

Swager, Anne-Fré; Curvers, Wouter L.; Bergman, Jacques J.

Pages: 81 –98

[Evaluation of patients with Barrett’s esophagus (BE) using dye-based chromoendoscopy, optical chromoendoscopy, autofluorescence imaging, or confocal laser endomicroscopy does not significantly increase the number of patients with a diagnosis of early neoplasia compared with high-definition white...
LitStream

Endoscopic Treatment of Early Barrett’s Neoplasia: Expanding Indications, New Challenges

Pech, Oliver

Pages: 99 –109

[Endoscopic therapy of early Barrett’s neoplasia is nowadays the treatment of choice and recommended over surgery in most current guidelines. Recent data suggest radiofrequency ablation of low-grade intraepithelial neoplasia when confirmed by an expert pathologist. Endoscopic therapy of...
LitStream

Definition, Derivation, and Diagnosis of Barrett’s Esophagus: Pathological Perspectives

Lowes, H.; Somarathna, T.; Shepherd, Neil A.

Pages: 111 –136

[More than 60 years have elapsed since Barrett described the condition that continues to bear his name. Despite much research, clinical and basic, the defining features and the diagnosis of columnar-lined esophagus (CLO) are still embroiled with controversy and uncertainty. For pathologists,...
LitStream

What Makes an Expert Barrett’s Histopathologist?

van der Wel, Myrtle J.; Jansen, Marnix; Vieth, Michael; Meijer, Sybren L.

Pages: 137 –159

[Clonal evolution to esophageal adenocarcinoma in Barrett’s esophagus (BO) is characterized by relentless clonal competition. Developing markers that capture the dynamics of clonal competition in BO patients for risk stratification purposes is a key goal of translational research. Dysplastic...
LitStream

Staging Early Esophageal Cancer

Old, O. J.; Isabelle, M.; Barr, H.

Pages: 161 –181

[Staging esophageal cancer provides a standardized measure of the extent of disease that can be used to inform decisions about therapy and guide prognosis. For esophageal cancer, the treatment pathways vary greatly depending on stage of disease, and accurate staging is therefore crucial in...
LitStream

Transcommitment: Paving the Way to Barrett’s Metaplasia

Wang, David H.; Souza, Rhonda F.

Pages: 183 –212

[Barrett’s esophagus is the condition in which metaplastic columnar epithelium that predisposes to cancer development replaces stratified squamous epithelium in the distal esophagus. Potential sources for the cell or tissue of origin for metaplastic Barrett’s epithelium are reviewed including...

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