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Computational Methods for Processing and Analysis of Biological Pathways

Part of the SpringerBriefs in Computer Science Book Series

DOI: 10.1007/978-3-319-53868-6

ISBN: 978-3-319-53867-9

Publisher: Springer International Publishing - Springer Journals

Mar 11, 2017

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Chapter 1Introduction

Bezerianos, Anastasios; Dragomir, Andrei; Balomenos, Panos

Pages: 1 –10

[This chapter presents an overview of the topics discussed throughout the book. The use of network representations for describing biological processes from a systems biology perspective is first highlighted. Subsequently, various types of biological networks are scrutinized and a synopsis of...
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Chapter 2Networks and Pathways in Systems Pharmacology

Bezerianos, Anastasios; Dragomir, Andrei; Balomenos, Panos

Pages: 11 –46

[This chapter presents an extensive overview of aspects involved in the thriving field of systems pharmacology. The three main directions along which network- and pathway-based analysis methods can contribute in systems pharmacology are spotlighted. Current approaches for the characterization of...
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Chapter 3Time-Varying Methods for Pathway and Sub-pathway Analysis

Bezerianos, Anastasios; Dragomir, Andrei; Balomenos, Panos

Pages: 47 –68

[This chapter presents in detail aspects related to pathway-based analysis of time-varying biological processes. Biological processes are inherently dynamical events involving genes and their products interacting within specific conditions. Genes are modulated by systemic perturbations (e.g.,...
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Chapter 4Identification of Differentially Expressed Pathways and Sub-pathways

Bezerianos, Anastasios; Dragomir, Andrei; Balomenos, Panos

Pages: 69 –87

[This chapter provides a survey of pathway and sub-pathway-based differential expression analysis. Differential expression analysis, the comparison of genes’ expression across various conditions, has become the primary tool for finding biomarkers, drug targets, and understanding the molecular...

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Computational Methods for Processing and Analysis of Biological Pathways

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