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The Immunology of Cardiovascular Homeostasis and Pathology

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1003)

Editors: Sattler, Susanne; Kennedy-Lydon, Teresa

DOI: 10.1007/978-3-319-57613-8

ISBN: 978-3-319-57611-4

Publisher: Springer International Publishing - Springer Journals

May 11, 2017

1 - 10 of 12 Chapters

LitStream

The Role of the Immune System Beyond the Fight Against Infection

Sattler, Susanne

Pages: 3 –14

[The immune system was identified as a protective factor during infectious diseases over a century ago. Current definitions and textbook information are still largely influenced by these early observations, and the immune system is commonly presented as a defence machinery. However, host defence...
LitStream

Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte

Knowlton, Anne A.

Pages: 17 –34

[The cardiac myocyte differs strikingly from the specialized cells of the immune system, which has two different responses to invading organisms and tissue damage. Adaptive or acquired immunity generates highly specific antibodies in response to threats and is an essential component of immunity;...
LitStream

Properties and Immune Function of Cardiac Fibroblasts

Furtado, Milena B.; Hasham, Muneer

Pages: 35 –70

[This chapter will discuss the role of cardiac fibroblasts as a target of various immunological inputs as well as an immunomodulatory hub of the heart through interaction with immune cell types and chemokine or cytokine signaling. While the purpose of this chapter is to explore the...
LitStream

Endothelial Cells

Sturtzel, Caterina

Pages: 71 –91

[Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link between the cardiovascular system and the immune system. Besides their commonly accepted roles in angiogenesis, hemostasis, and the regulation of vascular tone, they are an essential and active...
LitStream

Immune Functions and Properties of Resident Cells in the Heart and Cardiovascular System: Pericytes

Kennedy-Lydon, Teresa

Pages: 93 –103

[This chapter provides an introduction to pericyte physiology. Pericytes are smooth muscle-like cells that wrap around vessels and arterioles. Here, we discuss their structure, function, contractility and interaction with other cells including immune cells and finally their role in pathological...
LitStream

The Role of Cardiac Tissue Macrophages in Homeostasis and Disease

Ilinykh, Alexei; Pinto, Alexander R.

Pages: 105 –118

[Macrophages are principally recognized as an important cell type for removal of tissue debris and as sentinels for tissue damage and foreign antigens. However, macrophages also participate in a diverse range of biological processes including angiogenesis, fibrosis, immune modulation, cell...
LitStream

Atherosclerosis

Rahman, Mohammed Shamim; Woollard, Kevin

Pages: 121 –144

[In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. Herein we elaborate on the disease process that can...
LitStream

Immune-Mediated Heart Disease

Generali, Elena; Folci, Marco; Selmi, Carlo; Riboldi, Piersandro

Pages: 145 –171

[The heart involvement in systemic autoimmune diseases represents a growing burden for patients and health systems. Cardiac function can be impaired as a consequence of systemic conditions and manifests with threatening clinical pictures or chronic myocardial damage. Direct injuries are mediated...
LitStream

Vasculitis in the Central Nervous System

Bougea, Anastasia; Spantideas, Nikolaos

Pages: 173 –185

[Central nervous system (CNS) vasculitides are a heterogeneous group of disorders characterized by an inflammatory cell infiltration and necrosis of blood vessel walls in the brain, spinal cord, and the meninges. The CNS complications are likely to be fatal without judicious use of...
LitStream

Cardiac Autoimmunity: Myocarditis

Bracamonte-Baran, William; Čiháková, Daniela

Pages: 187 –221

[Myocarditis is the inflammation of the muscle tissues of the heart (myocardium). After a pathologic cardiac-specific inflammatory process, it may progress to chronic damage and dilated cardiomyopathy. The latter is characterized by systolic dysfunction, whose clinical correlate is heart failure....

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