DeepDyve eBooks - A Brief History of Blood and Lymphatic Vessels

Bikfalvi, Andreas

Pages: 1 –3

[Before going to the heart of the matter, the reader, if he or she does not already have a knowledge of biology, must familiarize him- or herself with a number of commonly used concepts and terminologies. The technical terminology and terms are easily understood and do not require specific...

Available

History of the Vascular System

Bikfalvi, Andreas

Pages: 5 –33

[The vision of the vascular system has undergone many changes during history (Table 2.1). Galen, a native of Pergamon (131–201 bc), was the personal physician of Emperor Marcus Aurelius (Fig. 2.1). He described the circulatory system as a one-way system in which the veins and arteries are only...

Available

Evolution of the Vascular System

Bikfalvi, Andreas

Pages: 35 –41

[Eukaryotic organisms are divided according to the usual taxonomy of protozoa and metazoans. Metazoans can be classified either as vertebrates and invertebrates or as diploblasts and triploblasts. Vertebrates have an internal cartilage framework and bone, which invertebrates lack. The...

Available

Where It All Began

Bikfalvi, Andreas

Pages: 43 –47

[Algire had observed changes in blood vessels when treating fibroblasts with a chemical methyl cholanthrene [98]. This suggests that factors (after stimulation) could be produced from the cells surrounding the blood vessels, such as fibroblasts that stimulate vascular growth.]

Available

Culture of Vascular Cells In Vitro

Bikfalvi, Andreas

Pages: 49 –52

[Ross Harrison (1870–1959) was the first to attempt to culture tissues in vitro using culture dishes. In 1907 he had grown tadpole tissue in a coagulated interstitial liquid from frog using the hanging drop technique [104]. This technique is still used today to generate spheroids in vitro and to...

Available

Discovery of the First Stimulating Factors of Blood Vessels

Bikfalvi, Andreas

Pages: 53 –55

[The work of Judah Folkman indicated that one or more factors produced by a tumor could stimulate angiogenesis. These factors were called tumor angiogenesis factors (TAFs), and various laboratories set out to identify these TAFs. The problem was that even if the culture medium or the extracts of...

Available

Vascular Endothelial Growth Factor: The Cornerstone of Vascular Development Factors

Bikfalvi, Andreas

Pages: 57 –59

[In 1986, Napoleone Ferrara and Jean Plouet (Fig. 7.1), both postdoctoral fellows in Denis Gospodarowicz’s laboratory in San Francisco, detected a stimulating activity of endothelial cells in the culture medium of bovine and mouse pituitary cells that was eluted from a heparin-sepharose column at...

Available

Inhibition of Angiogenesis, “Disappointments and Success”

Bikfalvi, Andreas

Pages: 61 –64

[Previous work by Judah Folkman had indicated that abnormal vascularization could be inhibited and that this could have a beneficial effect in pathological situations where vascularization was excessive. Many pharmacological substances are indeed capable of inhibiting the growth of endothelial...

Available

Stimulating Angiogenesis

Bikfalvi, Andreas

Pages: 65 –66

[Cardiovascular diseases (myocardial infarction, cerebral ischemia, or lower-limb arterial disease) contribute significantly to mortality and morbidity in our societies. These diseases are the result of arterial obstruction that consequently reduces the blood supply to the heart or to the...

Available

The Situation Is More Complex Than Anticipated

Bikfalvi, Andreas

Pages: 67 –89

[Vessels are not uniform tubes but are subdivided into arterial, venous, and lymphatic vessels. Large vessels (arteries, veins, large lymphatic trunks), medium-size vessels (arterioles, venules, medium-sized lymphatics), and capillaries are also distinguished. As we have just seen, the...

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A Brief History of Blood and Lymphatic Vessels

Advanced Search

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A Brief History of Blood and Lymphatic Vessels

Our policy towards the use of cookies