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Treatment of Esophageal and Hypopharyngeal Squamous Cell Carcinoma

Part of the Updates in Surgery Book Series

Editors: de Manzoni, Giovanni

DOI: 10.1007/978-88-470-2330-7

ISBN: 978-88-470-2329-1

Publisher: Springer Milan - Springer Journals

May 31, 2012

1 - 10 of 21 Chapters

LitStream

Epidemiology of Esophageal and Hypopharyngeal Squamous Cell Carcinoma

Verlato, Giuseppe; de Manzoni, Giovanni

Pages: 3 –11

[Esophageal cancer is the eighth most common cancer worldwide, with 481,000 new cases (3.8% all newly diagnosed cancers) estimated in 2008, and the sixth most common cause of death from cancer, with 406,000 deaths (5.4% of all cancer deaths) [1]. These figures encompass both of the major...
LitStream

Classification and Staging Systems

de Manzoni, Giovanni; Steccanella, Francesca; Zanoni, Andrea

Pages: 13 –21

[An accurate staging system for cancer aims at providing an indication of prognosis that is as accurate as possible. It also aids in treatment planning, the evaluation of treatment results, and the exchange of information between different centers.]
LitStream

Preoperative Work-up: Conventional Radiology, Ultrasonography, CT Scan, and MRI

Montemezzi, Stefania; Cenzi, Daniela; Motton, Massimiliano; Re, Thomas J.

Pages: 23 –47

[The optimal assessment and staging of esophageal cancer (EC) is crucial as it has an important impact on patient selection with respect to appropriate treatment (surgery, neo-adjuvant therapy with or without surgery, palliative treatment) [1]. Preoperative evaluation requires knowledge of the...
LitStream

Preoperative Work-up: EsophagoGastroDuodenoScopy, Tracheobronchoscopy, and Endoscopic Ultrasonography

Rodella, Luca; Cerofolini, Angelo; Lombardo, Francesco; Catalano, Filippo; Kheir, Walid El; de Manzoni, Giovanni

Pages: 49 –56

[Patients with esophageal squamous cell carcinoma (ESCC) frequently describe “alarm” symptoms, such as as dysphagia, bleeding, and weight loss. In these cases, endoscopy of the upper gastrointestinal (GI) tract is the first diagnostic examination usually performed. In a series of 4018 patients,...
LitStream

Preoperative Work-up: PET and PET-CT

Ambrosini, Valentina; Marzola, Maria Cristina; Caroli, Paola; Fanti, Stefano; Rubello, Domenico

Pages: 57 –62

[Esophageal cancer is characterized by an overall poor prognosis. Due to late onset of symptoms and early metastatic spread, only about 15–20% of patients undergo curative resection [1]. Accurate staging in esophageal squamous cell carcinoma (SCC) is essential to decide the correct therapeutic...
LitStream

Role of PET-CT in the Prediction of Response to Neoadjuvant Treatment

Fuster, David; Marzola, Maria Cristina; Pons, Francesca; de Manzoni, Giovanni; Rubello, Domenico

Pages: 63 –68

[Even if surgery is still the main therapeutic option in patients with esophageal squamous cell carcinoma (SCC), recent studies have shown that neoadjuvant chemoradiotherapy (CRT) can reduce the incidence of local recurrence and improve the overall survival rate [1–3].]
LitStream

Role of Molecular Biology in the Prediction of Response to Neoadjuvant Treatment

Gusella, Milena; Pasini, Felice; de Manzoni, Giovanni

Pages: 69 –76

[In esophageal cancer, molecular markers representing tumor biological properties or patient features could provide significant determinants for predicting therapeutic response. To date, however, there is no sufficient evidence that current diagnostic methods can be used to improve the efficacy...
LitStream

Patient Selection according to General Condition and Associated Disease

de Manzoni, Giovanni; Pedrazzani, Corrado; Zanoni, Andrea; Weindelmayer, Jacopo

Pages: 77 –85

[Esophagectomy and the complete spectrum of treatment of esophageal cancer are unanimously considered to be complex, with very high risks of treatment-related complications. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive disease that is usually diagnosed at an advanced stage....
LitStream

Esophageal Cancer Surgery: The Importance of Hospital Volume

de Manzoni, Giovanni; Di Leo, Alberto

Pages: 87 –92

[Esophagectomy for esophageal carcinoma is one of most demanding and traumatic surgical procedures undertaken in general surgery. Postoperative morbidity and mortality are usually high; nevertheless better outcomes have been noted in some high-volume specialized centers [1–4], with reported death...
LitStream

Surgical Treatment: Indications, Early and Long-term Results, and Disease Recurrence

de Manzoni, Giovanni; Barbieri, Franco; Zanoni, Andrea; Casella, Francesco

Pages: 95 –112

[Cancers of the hypopharynx and cervical esophagus used to be studied and treated together, due to the anatomical proximity of the two structures and the frequent infiltration of both. Nowadays, they are considered two different disease entities, with different symptoms, patterns of diffusion,...

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