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The Renin-Angiotensin System: Current Research Progress in The Pancreas

Part of the Advances in Experimental Medicine and Biology Book Series (volume 690)

DOI: 10.1007/978-90-481-9060-7

ISBN: 978-90-481-9059-1

Publisher: Springer Netherlands - Springer Journals

Aug 5, 2010

1 - 10 of 10 Chapters

LitStream

Overview of the Pancreas

Leung, Po Sing

Pages: 3 –12

[Structurally speaking, the human pancreas consists of two organs in one: an exocrine gland and an endocrine gland. The exocrine gland is made up of pancreatic acinar cells and duct cells that produce digestive enzymes and sodium bicarbonate, respectively. The primary function of the exocrine...
LitStream

Physiology of the Pancreas

Leung, Po Sing

Pages: 13 –27

[The pancreas plays a central role in digestion and absorption as well as utilization and storage of energy substrates. As described in Chapter 1, it consists of two structurally distinct but functionally integrated glandular systems, namely the exocrine and endocrine pancreas, both of which...
LitStream

Common Pancreatic Disease

Leung, Po Sing

Pages: 29 –51

[Pancreatitis is an inflammatory disease of the pancreas characterized by acute and chronic condition as well as varying duration and severity. Acute pancreatitis (AP) is a severe abdominal inflammation, characterized by parenchymal edema, necrosis with occasional presence of pseudocysts,...
LitStream

Circulating RAS

Leung, Po Sing

Pages: 55 –68

[The classical renin-angiotensin system (RAS), along with aldosterone (also called RAAS), plays an important role in the regulation of blood pressure and fluid homeostasis. This classical or circulating RAS consists of several major components including the precursor angiotensinogen, two critical...
LitStream

Local RAS

Leung, Po Sing

Pages: 69 –87

[The concept of a circulating RAS is well established and known to play an endocrine role in the regulation of fluid homeostasis (see Section 4.1, Chapter 4). However, it is more appropriate to view the RAS in the contemporary notion as an “angiotensin-generating system”, which consists of...
LitStream

Pancreatic RAS

Leung, Po Sing

Pages: 89 –105

[Metabolic syndrome disorder is a grave health problem affecting diverse populations worldwide. Among them, type 2 diabetes mellitus (T2DM) is a particularly widespread cardiometabolic syndrome which is characterized by impaired peripheral insulin sensitivity and pancreatic β-cell function. Its...
LitStream

Basic Techniques for Pancreatic Research

Leung, Po Sing

Pages: 109 –130

[Cell culture system studies complement animal studies, providing an indispensable tool for examining the underlying signalling mechanisms by which certain physiological responses are evoked and, at the same time, allowing observation to be attributed to distinct individual treatment factor. They...
LitStream

Current Research of the RAS in Diabetes Mellitus

Leung, Po Sing

Pages: 131 –153

[Type 2 diabetes mellitus (T2DM) accounts for more than 90% of human diabetes and the incidence of new cases is ever increasing worldwide; its prevalence thus places huge demands on healthcare resources and presents a new challenge for the control of disease globally. T2DM is a metabolic disease...
LitStream

Current Research Concerning the RAS in Pancreatic Stem Cells

Leung, Po Sing

Pages: 155 –177

[The explosion in the prevalence of diabetes mellitus has expanded beyond the Western world into Asian countries such as China. Given the complication of diabetes, this expanding prevalence carries an attendant medical, social and financial burden for countries with afflicted populations. Central...
LitStream

Current Research of the RAS in Pancreatitis and Pancreatic Cancer

Leung, Po Sing

Pages: 179 –199

[A local RAS exists in several cell types of the pancreas, which exhibits both exocrine and endocrine activities, and this functional local RAS is responsive to various physiological and pathophysiological stimuli (see Chapter 6). Of particular interest in this context are the expression and...

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