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Nanomaterial

Part of the Advances in Experimental Medicine and Biology Book Series (volume 811)

Editors: Capco, David G.; Chen, Yongsheng

DOI: 10.1007/978-94-017-8739-0

ISBN: 978-94-017-8738-3

Publisher: Springer Netherlands - Springer Journals

Mar 10, 2014

1 - 10 of 13 Chapters

LitStream

Chapter 1Presence in, and Release of, Nanomaterials from Consumer Products

Yang, Yu; Westerhoff, Paul

Pages: 1 –17

[Widespread use of engineered nanomaterials (ENMs) in consumer products has led to concerns about their potential impact on humans and the environment. In order to fully assess the impacts and release of ENMs from consumer products, this chapter provides an overview of the types of consumer...
LitStream

Chapter 2Nanoparticle Aggregation: Principles and Modeling

Zhang, Wen

Pages: 19 –43

[The high surface area to volume ratio of nanoparticles usually results in highly reactive and colloidal instability compared to their bulk counterparts. Aggregation as well as many other transformations (e.g., dissolution) in the environment may alter the physiochemical properties, reactivity,...
LitStream

Chapter 3Influences of Nanomaterials on the Barrier Function of Epithelial Cells

Ali, Shariq; Rytting, Erik

Pages: 45 –54

[Recent advances in nanotechnology have led to exciting opportunities in medicine, energy, manufacturing, and other fields. Nevertheless, it is important to adequately assess the potential impacts of nanomaterial exposure. This chapter focuses on the interactions of nanomaterials with epithelial...
LitStream

Chapter 4Engineered Nanoparticles Induced Brush Border Disruption in a Human Model of the Intestinal Epithelium

Faust, James J.; Masserano, Benjamin M.; Mielke, Adam H.; Abraham, Anup; Capco, David G.

Pages: 55 –72

[Nanoparticles hold great promise in cell biology and medicine due to the inherent physico-chemical properties when these materials are synthesized on the nanoscale. Moreover, their small size, and the ability to functionalize the outer nanoparticle surface makes them an ideal vector suited to...
LitStream

Chapter 5Nanoparticles: Cellular Uptake and Cytotoxicity

Adjei, Isaac M.; Sharma, Blanka; Labhasetwar, Vinod

Pages: 73 –91

[Understanding the interactions of nanoparticles (NPs) with cells and how these interactions influence their cellular uptake is essential to exploring the biomedical applications of NPs, particularly for drug delivery. Various factors, whether differences in physical properties of NPs or...
LitStream

Chapter 6Atomic Force Microscopy Study of the Interaction of DNA and Nanoparticles

Li, Kungang; Du, Songyan; Van Ginkel, Steven; Chen, Yongsheng

Pages: 93 –109

[The interaction between nanoparticles (NPs) and DNA plays an important role in the genotoxicity of NPs, and it is imperative to characterize the nano/DNA interactions and explore the underlying chemical mechanisms. In this chapter, we demonstrated systematic experimental approaches based on...
LitStream

Chapter 7Intracellular Signal Modulation by Nanomaterials

Hussain, Salik; Garantziotis, Stavros; Rodrigues-Lima, Fernando; Dupret, Jean-Marie; Baeza-Squiban, Armelle; Boland, Sonja

Pages: 111 –134

[A thorough understanding of the interactions of nanomaterials with biological systems and the resulting activation of signal transduction pathways is essential for the development of safe and consumer friendly nanotechnology. Here we present an overview of signaling pathways induced by...
LitStream

Chapter 8Nanomaterials: Impact on Cells and Cell Organelles

Krpetić, Željka; Anguissola, Sergio; Garry, David; Kelly, Philip M.; Dawson, Kenneth A.

Pages: 135 –156

[Colloidal nanoparticles designed for the interactions with cells are very small, nanoscale objects usually consisting of inorganic cores and organic shells that are dispersed in a buffer or biological medium. By tuning the material properties of the nanoparticles a number of different biological...
LitStream

Chapter 9Design, Synthesis, and Functionalization of Nanomaterials for Therapeutic Drug Delivery

Grandhi, Taraka Sai Pavan; Rege, Kaushal

Pages: 157 –182

[Nanomaterials have the potential to solve some of the toughest challenges facing modern medicine. Their unique optical, magnetic and chemical properties at the nanoscale make them different from their macroscale counterparts. Successful application of nanomaterials can revolutionize...
LitStream

Chapter 10Preparation of Nanoscale Pulmonary Drug Delivery Formulations by Spray Drying

Bohr, Adam; Ruge, Christian A.; Beck-Broichsitter, Moritz

Pages: 183 –206

[Advances in preparation technologies for nanomedicines have provided novel formulations for pulmonary drug delivery. Application of drugs via the lungs can be considered as one of the most attractive implementations of nanoparticles for therapeutic use due to the unique anatomy and physiology of...

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