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Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells

Part of the Springer Theses Book Series

DOI: 10.1007/978-94-017-8819-9

ISBN: 978-94-017-8818-2

Publisher: Springer Netherlands - Springer Journals

May 20, 2014

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Chapter 1Introduction

Zhao, Xiaoyang

Pages: 1 –26

[The birth of the first cloned mammal “Dolly” and the establishment of human embryonic stem cell lines were landmarks in regenerative biology, indicating that mankind had achieved a huge breakthrough in somatic cell reprogramming and stem cell research. Recently, with the emergence of new...
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Chapter 2Establishment of ESC Lines Derived from Mice, Rats, and Primate

Zhao, Xiaoyang

Pages: 27 –39

[The first embryonic stem cell line was established from mice, which served as an important tool for ESC pluripotency and self-renewal studies. BN rat is the most widely used experiment model, it is important to generate the gene knockout animal model in BN rat for biology research. Gene...
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Chapter 3Establishment of Highly Efficient Somatic Cell Reprogramming System to Generate iPSC Lines

Zhao, Xiaoyang

Pages: 41 –52

[The generation of iPSC by overexpression of transcription factors was a breakthrough in the field of regenerative medicine. This technique is helpful for personalized regenerative medicine. However, the low induction efficiency and the potential safety problem were two obstacles for clinical...
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Chapter 4Pluripotency of iPSC and the Underlining Mechanism

Zhao, Xiaoyang

Pages: 53 –74

[iPSC technology through transfection of the four transcription factors, Oct4, Sox2, Klf4, and c-Myc, can reprogram somatic cells to pluripotent stem cells, which are similar to embryonic stem cells (ESC). It is currently the most popular reprogramming method and has been successfully applied in...
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Chapter 5Developmental Potential of Mouse iPSC

Zhao, Xiaoyang

Pages: 75 –89

[iPSC is the most popular reprogramming method that may be applied in regenerative medicine. However, even if iPSCs were induced in the same condition, there exist the full-reprogrammed iPSCs mixed with partially reprogrammed iPSCs. Partial reprogramming iPSCs have limited differentiation...
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Chapter 6Conclusion

Zhao, Xiaoyang

Pages: 91 –92

[The pluripotent stem cells are a promising cell source for cell therapy. However, the generation of fully reprogrammed and safer pluripotent stem cells is still challenging. In this dissertation, I focused on the generation of fully reprogrammed iPS cells, the quality control of iPSC induction,...

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