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Exosomes in Cardiovascular Diseases

Part of the Advances in Experimental Medicine and Biology Book Series (volume 998)

Editors: Xiao, Junjie; Cretoiu, Sanda

DOI: 10.1007/978-981-10-4397-0

ISBN: 978-981-10-4396-3

Publisher: Springer Singapore - Springer Journals

Jun 20, 2017

1 - 10 of 19 Chapters

LitStream

The Multifaceted Functions of Exosomes in Health and Disease: An Overview

Arenaccio, Claudia; Federico, Maurizio

Pages: 3 –19

[Exosomes are extracellular vesicles of 50–150 nm in diameter secreted by basically all cell types. They mediate micro-communication among cells, tissues, and organs under both healthy and disease conditions by virtue of their ability to deliver macromolecules to target cells. Research on...
LitStream

Exosomes: Nanocarriers of Biological Messages

Conigliaro, Alice; Fontana, Simona; Raimondo, Stefania; Alessandro, Riccardo

Pages: 23 –43

[Cell-cell communication is crucial to maintain homeostasis in multicellular organism. Cells communicate each other by direct contact or by releasing factors that, soluble or packaged in membrane vesicles, can reach different regions of the organism. To date numerous studies highlighted the...
LitStream

Functional Role of Cardiovascular Exosomes in Myocardial Injury and Atherosclerosis

Vanhaverbeke, Maarten; Gal, Diane; Holvoet, Paul

Pages: 45 –58

[Extracellular vesicles are now widely recognized as key players in the prevention, repair or progression of cardiovascular disease. Here we first focus on the functional roles of extracellular vesicles in the cross-talk between cardiomyocytes and endothelial cells, important for maintaining...
LitStream

Exosomes as Diagnostic Biomarkers in Cardiovascular Diseases

Jansen, Felix; Li, Qian

Pages: 61 –70

[Exosomes play important roles in the development and progression of cardiovascular diseases by modulating intercellular communication. Contents and quantities of exosomes are variable under different pathological cardiovascular conditions. Based on these concepts, exosomes have been proposed as...
LitStream

Exosomes-Based Biomarkers for the Prognosis of Cardiovascular Diseases

Bei, Yihua; Yu, Pujiao; Cretoiu, Dragos; Cretoiu, Sanda Maria; Xiao, Junjie

Pages: 71 –88

[Cardiovascular diseases (CVDs) have a high prevalence and annually increasing incidence with high mortality and morbidity. Identification of biomarkers with high sensitivity and specificity for assessing the prognosis of CVDs is necessary for optimizing personalized treatment and reducing...
LitStream

Exosomes as New Intercellular Mediators in Development and Therapeutics of Cardiomyocyte Hypertrophy

Huang, Qi; Cai, Benzhi

Pages: 91 –100

[Myocardial hypertrophy is a common cardiac condition in response to hemodynamic and neurohormonal alterations. Pathological hypertrophic growth in hearts caused the decline of cardiac functions, and finally developed into congestive heart failure. The exosomes are small membrane vesicles which...
LitStream

Dual Behavior of Exosomes in Septic Cardiomyopathy

Monteiro, Valter Vinícius Silva; Reis, Jordano Ferreira; de Souza Gomes, Rafaelli; Navegantes, Kely Campos; Monteiro, Marta Chagas

Pages: 101 –112

[Sepsis is one of the main causes of ICU hospitalization worldwide, with a high mortality rate, and is associated with a large number of comorbidities. One of the main comorbidities associated with sepsis is septic cardiomyopathy. This process occurs mainly due to mechanisms of damage in the...
LitStream

Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy

Salem, Esam S. B.; Fan, Guo-Chang

Pages: 113 –138

[Diabetic subjects are at risk of developing cardiovascular disease, which accounts for 60–80% of diabetes-related mortality. Atherosclerosis is still considered as a leading cause of heart failure in diabetic patients, but it could also be an intrinsic and long-term effect of contractile cardiac...
LitStream

Peripartum Cardiomyopathy: Do Exosomes Play a Role?

Gu, Huanyu; Dai, Qiying; Liu, Zhuyuan; Wang, Hongbao; Yao, Jianhua; Zhou, Lei

Pages: 139 –149

[Peripartum cardiomyopathy (PPCM) refers to irreversible cardiomyocyte damage that occurs during the last month of pregnancy, or within 5 months after giving birth. It is characterized by systolic heart failure. This life-threatening condition is relatively uncommon, but the incidence has been...
LitStream

Vascular Calcification Regulation by Exosomes in the Vascular Wall

Liberman, Marcel; Marti, Luciana Cavalheiro

Pages: 151 –160

[Vascular calcification is a tightly regulated process that increases during ageing and occurs mainly in patients with diabetes and chronic renal failure. Exosomes are small membrane vesicles that are synthesized in a particular population of endosomes, also called multivesicular bodies, by...

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