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Dengue and Zika: Control and Antiviral Treatment Strategies

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1062)

Editors: Hilgenfeld, Rolf; Vasudevan, Subhash G.

DOI: 10.1007/978-981-10-8727-1

ISBN: 978-981-10-8726-4

Publisher: Springer Singapore - Springer Journals

May 30, 2018

1 - 10 of 25 Chapters

LitStream

Chapter 1Arboviruses: A Family on the Move

Young, Paul R.

Pages: 1 –10

[Arboviruses are a diverse group of vector-borne viruses, many of whose members are the cause of significant human morbidity and mortality. Over the last 30 years, the emergence and/or resurgence of arboviruses have posed a considerable global health threat. The ongoing geographical expansion of...
LitStream

Chapter 2Historical Perspective of Arboviruses in Mozambique and Its Implication for Current and Future Epidemics

Gudo, Eduardo Samo; Falk, Kerstin; Cliff, Julie

Pages: 11 –18

[Mozambique is a tropical country situated in the Southern part of Africa, a region where data on the burden and epidemiology of arbovirus is presently quite scarce although the frequency of outbreaks caused by arboviruses is rapidly increasing. Outbreaks of dengue fever have been reported in...
LitStream

Chapter 3Reliable Serological Testing for the Diagnosis of Emerging Infectious Diseases

Ohst, Claudia; Saschenbrecker, Sandra; Stiba, Konstanze; Steinhagen, Katja; Probst, Christian; Radzimski, Christiane; Lattwein, Erik; Komorowski, Lars; Stöcker, Winfried; Schlumberger, Wolfgang

Pages: 19 –43

[Climate change, increased urbanization and international travel have facilitated the spread of mosquito vectors and the viral species they carry. Zika virus (ZIKV) is currently spreading in the Americas, while dengue virus (DENV) and chikungunya virus (CHIKV) have already become firmly...
LitStream

Chapter 4Flaviviral RNA Structures and Their Role in Replication and Immunity

Bidet, Katell; Garcia-Blanco, Mariano A.

Pages: 45 –62

[More than simple vectors of genetic information, flaviviral RNAs have emerged as critical regulators of the virus life cycle. Viral RNAs regulate interactions with viral and cellular proteins in both, mosquito and mammalian hosts to ultimately influence processes as diverse as RNA replication,...
LitStream

Chapter 5The Molecular Specificity of the Human Antibody Response to Dengue Virus Infections

Gallichotte, Emily N.; Baric, Ralph S.; de Silva, Aravinda M.

Pages: 63 –76

[Dengue viruses (DENV) are mosquito-borne positive sense RNA viruses in the family Flaviviridae. The four serotypes of DENV (DENV1, DENV2, DENV3, DENV4) are widely distributed and it is estimated over a third of the world’s population is at risk of infection [4]. While the majority of infections...
LitStream

Chapter 6Structures of Zika Virus E & NS1: Relations with Virus Infection and Host Immune Responses

Shi, Yi; Dai, Lianpan; Song, Hao; Gao, George F.

Pages: 77 –87

[Zika virus (ZIKV), first discovered in the Zika forest in Uganda in 1947 was understudied until the recent explosive epidemic in several South American countries where it has become strongly associated with congenital birth defects leading to severe cranial malformations and neurological...
LitStream

Chapter 7Plugging the Leak in Dengue Shock

Watterson, Daniel; Modhiran, Naphak; Muller, David A.; Stacey, Katryn J.; Young, Paul R.

Pages: 89 –106

[Recent structural and functional advances provide fresh insight into the biology of the dengue virus non-structural protein, NS1 and suggest new avenues of research. The work of our lab and others have shown that the secreted, hexameric form of NS1 has a systemic toxic effect, inducing...
LitStream

Chapter 8Viral Entry and NS1 as Potential Antiviral Drug Targets

de Silva, Aravinda M.; Rey, Félix A.; Young, Paul R.; Hilgenfeld, Rolf; Vasudevan, Subhash G.

Pages: 107 –113

[A general discussion on viral entry and NS1 as potential drug targets was held at the Tofo Advanced Study Week (TASW) on Emerging Viral Diseases in September 2016. The opportunities and gaps for developing therapeutic countermeasures, to take advantage of the high-resolution cryo-electron...
LitStream

Chapter 9The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity

Lescar, Julien; Soh, Sherryl; Lee, Le Tian; Vasudevan, Subhash G.; Kang, Congbao; Lim, Siew Pheng

Pages: 115 –129

[Viruses from the Flavivirus family are the causative agents of dengue fever, Zika, Japanese encephalitis, West Nile encephalitis or Yellow fever and constitute major or emerging public health problems. A better understanding of the flavivirus replication cycle is likely to offer new...
LitStream

Chapter 10The Structure of the Zika Virus Protease, NS2B/NS3pro

Hilgenfeld, Rolf; Lei, Jian; Zhang, Linlin

Pages: 131 –145

[In this chapter, we first briefly review the history of Zika virus (ZIKV) over the past 70 years since its discovery. We then focus on the ZIKV NS2B/NS3 protease, a major potential target for anti-ZIKV therapeutics. We describe the structure of the complex between Zika virus NS2B-NS3 protease...

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