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Thermodynamics and Biophysics of Biomedical Nanosystems

Part of the Series in BioEngineering Book Series

Editors: Demetzos, Costas; Pippa, Natassa

DOI: 10.1007/978-981-13-0989-2

ISBN: 978-981-13-0988-5

Publisher: Springer Singapore - Springer Journals

Mar 5, 2019

1 - 10 of 13 Chapters

LitStream

Chapter 1Introducing Thermodynamics and Biophysics in Health Sciences

Demetzos, Costas; Pippa, Natassa

Pages: 1 –11

[Biophysics and thermodynamics are effectively distributed in life sciences guided by the fields of biology and physics, respectively. The main concern raised regarding the usefulness of such scientific fields on the development and evaluation of therapeutic products as part of the research in...
LitStream

Chapter 2Methodological Approaches for the Characterization of the Self-assembling Behaviour in the Pharmaceutical Field

Perinelli, Diego Romano; Bonacucina, Giulia

Pages: 13 –37

[Self-assembling is a thermodynamic process in which single components aggregate into large ordered structure as a function of temperature and concentration. Self-assembling has been longer exploited in the pharmaceutical field for the development of colloidal delivery systems for therapeutic,...
LitStream

Chapter 3Phase Transitions in Biological Membranes

Heimburg, Thomas

Pages: 39 –61

[Native membranes of biological cells display melting transitions of their lipids at a temperature of 10–20 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs}...
LitStream

Chapter 4Isothermal Titration Calorimetry: A Powerful Tool for the Characterization of Molecular Interactions

Thanassoulas, Angelos; Nounesis, George

Pages: 63 –103

[Isothermal titration calorimetry (ITC) is a well-established technique that allows the accurate and precise determination of binding equilibrium constants. It is able to provide detailed thermodynamic description of reacting systems without the need for van’t Hoff analysis. ITC plays an...
LitStream

Chapter 5Dynamics of Iron Homeostasis in Health and Disease: Molecular Mechanisms and Methods for Iron Determination

Ploumi, Christina; Kyriakakis, Emmanouil; Tavernarakis, Nektarios

Pages: 105 –145

[Iron is a versatile trace metal, indispensable for the survival of all living organisms. Despite its crucial role in vital biological processes, exceeded iron levels can be harmful for cellular and organismal homeostasis, due to iron’s involvement in the generation of toxic hydroxyl radicals. As...
LitStream

Chapter 6Achieving Selective Targeting Using Engineered Nanomaterials

Lanfranco, Roberta; Mognetti, Bortolo M.; Bruylants, Gilles

Pages: 147 –182

[The development of Drug Delivery Systems (DDS) able to selectively deliver a controlled amount of a drug only to diseased cells would represent a dramatic development in nanomedicine. One of the multiple challenges still paving the way towards this goal is the elaboration of strategies that...
LitStream

Chapter 7PAMAM and PPI Dendrimers in Biophysical and Thermodynamic Studies on the Delivery of Therapeutic Nucleotides, Nucleosides and Nucleobase Derivatives for Anticancer Applications

Gorzkiewicz, Michał; Buczkowski, Adam; Pałecz, Bartłomiej; Klajnert-Maculewicz, Barbara

Pages: 183 –243

[In the recent years a number of reports have emerged on the use of dendrimers as nanocarriers for many therapeutic compounds. These polyvalent, monodisperse, usually globular macromolecules, due to their well-defined, highly-branched structure, provide improved solubility of the drugs, high...
LitStream

Chapter 8Thermal Analysis of Glass-Ceramics and Composites in Biomedical and Dental Sciences

Theodorou, George S.; Patsiaoura, Dimitra; Kontonasaki, Eleana; Chrissafis, Konstantinos

Pages: 245 –295

[In this chapter, thermal analysis techniques are discussed concerning glass-ceramics and composites in the fields of Biomedical and Dental Sciences. A brief description of how thermal analysis techniques are applied in those fields, as well as their basic principles are described. Fundamental...
LitStream

Chapter 9Differential Scanning Calorimetry (DSC): An Invaluable Tool for the Thermal Evaluation of Advanced Chimeric Liposomal Drug Delivery Nanosystems

Chountoulesi, Maria; Naziris, Nikolaos; Pippa, Natassa; Pispas, Stergios; Demetzos, Costas

Pages: 297 –337

[Chimeric liposomal systems are classified as advanced drug delivery nanosystems, being composed of different kinds of biomaterials, such as phospholipids and polymers. Chimeric liposomes present many advantages, compared to conventional ones, such as great functionality, stimuli-responsiveness...
LitStream

Chapter 10Drug-Membrane Interactions in the Renin Angiotensin System

Ntountaniotis, Dimitrios; Kellici, Tahsin F.; Gkeka, Paraskevi; Cournia, Zoe; Galdadas, Ioannis; Mali, Gregor; Becker-Baldus, Johanna; Glaubitz, Clemens; Kriechbaum, Manfred; Rappolt, Michael; Liapakis, George; Mavromoustakos, Thomas

Pages: 339 –364

[Renin Angiotensin System (RAS) plays a key role in the pathophysiology of the cardiovascular and renal system. Within this system stimulation of the G-protein coupled receptor (GPCR) AT1 by the peptide angiotensin II (AII) has a central role. Molecules have been discovered which either block the...

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