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Biochemical and Biophysical Roles of Cell Surface Molecules

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1112)

Editors: Chattopadhyay, Kausik; Basu, Subhash C.

DOI: 10.1007/978-981-13-3065-0

ISBN: 978-981-13-3064-3

Publisher: Springer Singapore - Springer Journals

Jan 13, 2019

1 - 10 of 24 Chapters

LitStream

Status of Membrane Asymmetry in Erythrocytes: Role of Spectrin

Sarkar, Sauvik; Bose, Dipayan; Giri, Rajendra P.; Mukhopadhyay, Mrinmay K.; Chakrabarti, Abhijit

Pages: 3 –11

[Spectrin-based proteinaceous membrane skeletal network has been found to be implicated in membrane disorders like hereditary spherocytosis (HS). HS greatly affects eryptosis via loss of membrane asymmetry which is seen to be the case in haemoglobin disorders like thalassemia and sickle cell...
LitStream

Multiple Roles, Multiple Adaptors: Dynein During Cell Cycle

Dwivedi, Devashish; Sharma, Mahak

Pages: 13 –30

[Dynein is an essential protein complex present in most eukaryotes that regulate biological processes ranging from ciliary beating, intracellular transport, to cell division. Elucidating the detailed mechanism of dynein function has been a challenging task owing to its large molecular weight and...
LitStream

Changes in the Nuclear Envelope in Laminopathies

Dutta, Subarna; Bhattacharyya, Maitree; Sengupta, Kaushik

Pages: 31 –38

[Double-membrane-bound nucleus is the major organelle of every metazoan cell, which controls various nuclear processes like chromatin maintenance, DNA replication, transcription and nucleoskeleton-cytoskeleton coupling. Nuclear homeostasis depends on the integrity of nuclear membrane and...
LitStream

The Effect of Nanoparticles on the Cluster Size Distributions of Activated EGFR Measured with Photobleaching Image Correlation Spectroscopy

Paviolo, Chiara; Chon, James W. M.; Clayton, Andrew H. A.

Pages: 41 –52

[The epidermal growth factor receptor (EGFR) is an important cell surface receptor in normal physiology and disease. Recent work has shown that EGF-gold nanoparticle conjugates can influence cell behaviour, but the underlying mechanism at the receptor quaternary structural level remains poorly...
LitStream

Factors Influencing the Chaperone-Like Activity of Major Proteins of Mammalian Seminal Plasma, Equine HSP-1/2 and Bovine PDC-109: Effect of Membrane Binding, pH and Ionic Strength

Kumar, Cheppali Sudheer; Singh, Bhanu Pratap; Alim, Sk.; Swamy, Musti J.

Pages: 53 –68

[HSP-1/2 and PDC-109 belong to a family of fibronectin type II proteins, present in high concentrations in bovine and equine seminal plasma, respectively. These proteins act as extracellular small heat shock proteins and protect target/client proteins against various kinds of stress. They also...
LitStream

Exploring the Mechanism of Viral Peptide-Induced Membrane Fusion

Pattnaik, Gourab Prasad; Meher, Geetanjali; Chakraborty, Hirak

Pages: 69 –78

[Membrane fusion is essential in several cellular processes in the existence of eukaryotic cells such as cellular trafficking, compartmentalization, intercellular communication, sexual reproduction, cell division, and endo- and exocytosis. Membrane fusion proceeds in model membranes as well as...
LitStream

Amyloids Are Novel Cell-Adhesive Matrices

Jacob, Reeba S.; Das, Subhadeep; Singh, Namrata; Patel, Komal; Datta, Debalina; Sen, Shamik; Maji, Samir K.

Pages: 79 –97

[Amyloids are highly ordered peptide/protein aggregates traditionally associated with multiple human diseases including neurodegenerative disorders. However, recent studies suggest that amyloids can also perform several biological functions in organisms varying from bacteria to mammals. In many...
LitStream

The Prospects of Cadherin-23 as a Mediator of Homophilic Cell-Cell Adhesion

Sannigrahi, Malay Kumar; Srinivas, Sai; Rakshit, Sabyasachi

Pages: 99 –105

[Cadherins (calcium-dependent adhesion proteins) constitute a family of cell surface proteins that mediate cell-cell adhesion and actively participate in tissue morphogenesis and in mediating tissue integrity. The ecto-domains of cadherins from opposing cell surfaces interact with each other to...
LitStream

Structural-Mechanical and Biochemical Functions of Classical Cadherins at Cellular Junctions: A Review and Some Hypotheses

Tiwari, Prince; Mrigwani, Arpita; Kaur, Harpreet; Kaila, Pallavi; Kumar, Rajendra; Guptasarma, Purnananda

Pages: 107 –138

[This article begins with a general review of cell adhesion molecules (CAMs) and narrows the focus down progressively to the cadherins (calcium binding-dependent CAMs), classifications of subfamilies of the cadherins, type I (E- and N-) cadherins, evolutionary relationships amongst cadherins,...
LitStream

Identification of Sphingolipid-binding Motif in G Protein-coupled Receptors

Shrivastava, Sandeep; Jafurulla, Md.; Tiwari, Shrish; Chattopadhyay, Amitabha

Pages: 141 –149

[Sphingolipids correspond to a major class of lipids which serve as indispensable structural components of membranes and play an important role in various cellular functions. They constitute ~10–20% of total membrane lipids and are known to form segregated domains in biological membranes....

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