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Stem Cell-based Therapy for Neurodegenerative Diseases

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1266)

Editors: Han, Fabin; Lu, Pengzhe (Paul)

DOI: 10.1007/978-981-15-4370-8

ISBN: 978-981-15-4369-2

Publisher: Springer Singapore - Springer Journals

Oct 27, 2020

1 - 10 of 10 Chapters

LitStream

Chapter 1Introduction for Stem Cell–Based Therapy for Neurodegenerative Diseases

Han, Fabin; Lu, Paul

Pages: 1 –8

[Neurodegenerative diseases (NDs) are a group of neurological diseases caused by the progressive degeneration of neurons and glial cells in the brain and spinal cords. Usually there is a selective loss of specific neuronal cells in a restricted brain area from any neurodegenerative diseases, such...
LitStream

Chapter 2Quality Standards of Stem Cell Sources for Clinical Treatment of Neurodegenerative Diseases

Han, Fabin; Gu, Yongquan; Zhao, Hui; Chen, Lin

Pages: 9 –19

[A large number of experimental and clinical studies have shown that cell transplantation has therapeutic effects for PD, AD and other neurodegenerative diseases or damages. Good Manufacturing Practice (GMP) guidance must be defined to produce clinical-grade cells for transplantation to the...
LitStream

Chapter 3Stem Cell Therapy for Parkinson’s Disease

Han, Fabin; Hu, Baoyang

Pages: 21 –38

[Parkinson’s disease (PD) is one of the most common neurodegenerative diseases caused by specific degeneration and loss of dopamine neurons in substantia nigra of the midbrain. PD is clinically characterized by motor dysfunctions and non-motor symptoms. Even though the dopamine replacement can...
LitStream

Chapter 4Stem Cell Therapy for Alzheimer’s Disease

Han, Fabin; Bi, Jianzhong; Qiao, Liyan; Arancio, Ottavio

Pages: 39 –55

[Alzheimer’s disease (AD) is the most common neurodegenerative disease caused by eventually aggregated amyloid β (Aβ) plaques in degenerating neurons of the aging brain. These aggregated protein plaques mainly consist of Aβ fibrils and neurofibrillary tangles (NFTs) of phosphorylated tau protein....
LitStream

Chapter 5Cell Replacement Therapy for Huntington’s Disease

Monk, Ruth; Connor, Bronwen

Pages: 57 –69

[Huntington’s disease (HD) is an inherited neurodegenerative disorder which is characterised by a triad of highly debilitating motor, cognitive, and psychiatric symptoms. While cell death occurs in many brain regions, GABAergic medium spiny neurons (MSNs) in the striatum experience preferential...
LitStream

Chapter 6Stem Cell Transplantation for Amyotrophic Lateral Sclerosis

Zhu, Qiang; Lu, Paul

Pages: 71 –97

[Amyotrophic lateral sclerosis (ALS) is a motor neuronal degeneration disease, in which the death of motor neurons causes lost control of voluntary muscles. The consequence is weakness of muscles with a wide range of disabilities and eventually death. Most patients died within 5 years after...
LitStream

Chapter 7Stem Cells Therapy for Multiple Sclerosis

Abi Chahine, Nassim; Lu, Paul

Pages: 99 –115

[Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system (CNS) associated with inflammatory plaques of white matter demyelination, oligodendrocyte destruction, reactive gliosis and axonal degeneration. In this chapter, we first review the pathological...
LitStream

Chapter 8Cell-Based Therapy for Spinal Muscular Atrophy

Han, Fabin; Ebrahimi-Barough, Somayeh; Abolghasemi, Reyhaneh; Ai, Jafar; Liu, Yanming

Pages: 117 –125

[Spinal muscular atrophy (SMA) is a devastating neurodegenerative disease characterized by the degeneration of lower motor neurons in the spinal cord, leading to progressive paralysis and early death in the severe cases. SMA is primarily caused by the mutations in the gene of SMN (survival motor...
LitStream

Chapter 9Stem Cell Transplantation Therapy for Retinal Degenerative Diseases

Han, Fabin; Xu, Guotong

Pages: 127 –139

[In the past decade, progress in the research on human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) has provided the solid basis to derive retinal pigment epithelium, photoreceptors, and ganglion cells from hESCs/iPSCs for transplantation therapy of retinal degenerative...
LitStream

Chapter 10Future Challenges and Perspectives for Stem Cell Therapy of Neurodegenerative Diseases

Han, Fabin; Lu, Paul

Pages: 141 –145

[Stem cell-based therapy has shown exciting efficacy in pre-clinical studies on different neurodegenerative diseases (NDs). However, no clinically applicable stem-cell-derived neurons are available to the patients with NDs. There exist some obstacles associated with stem cell therapy, which need...

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