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Acoustic Levitation-Based Trace-Level Biosensing

Part of the Springer Theses Book Series

DOI: 10.1007/978-981-16-1425-5

ISBN: 978-981-16-1424-8

Publisher: Springer Singapore - Springer Journals

Apr 21, 2021

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Chapter 1Introduction

Miyagawa, Akihisa

Pages: 1 –20

[In this chapter, the background of ultrasound and the application of particle separation using various external fields are introduced. The features and applications of ultrasound are discussed in Sect. 1.1. Particle separation and manipulation using external fields, such as dielectric, magnetic,...
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Chapter 2Theory of Combined Acoustic-Gravitational Field

Miyagawa, Akihisa

Pages: 21 –33

[In this chapter, the principle of an acoustic radiation force and a combined acoustic-gravitational (CAG) field is discussed. From Sect. 2.1 to Sect. 2.4, the mathematical interpretation of the acoustic radiation force is described. Based on this, the principle of the CAG field is constructed in...
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Chapter 3Principle of Detection Based on Particle Levitation in Coupled Acoustic-Gravitational Field

Miyagawa, Akihisa

Pages: 35 –42

[In this chapter, the detection principle based on particle levitation in a coupled acoustic-gravitational (CAG) field is theoretically described. A detection concept based on particle levitation is described in Sect. 3.1. The dependence of the levitation coordinate on the density and size of the...
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Chapter 4Detection of the Avidin–Biotin Reaction

Miyagawa, Akihisa

Pages: 43 –59

[In this section, a detection scheme based on the levitation coordinate shift of a microparticle by the binding of AuNPs is demonstrated. The relationship between the particle density and the levitation coordinate is studied using gold-plated PMMA microparticles in Sect. 4.2. In addition, the...
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Chapter 5Label-Free Detection for DNA/RNA Molecules

Miyagawa, Akihisa

Pages: 61 –78

[In Chapter 4, a zmol-sensing scheme based on the levitation behavior of a single microparticle is proposed. However, this detection scheme needs the anchoring of target molecules on the microparticle or AuNP, which may lead to a change in the chemical and/or physical properties of the target...
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Chapter 6Aptamer-Based Sensing of Small Organic Molecules

Miyagawa, Akihisa

Pages: 79 –88

[In this chapter, a system based on sandwich hybridization is applied to the detection of small organic molecules using an aptamer. Aptamer is a DNA molecule with a specific sequence that selectively binds to a target. Aptamer DNA mediates the binding between PMMA and AuNPs to form AuNP-bound...
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Chapter 7Conclusion and Outlook

Miyagawa, Akihisa

Pages: 89 –91

[Acoustic levitation-based biosensing at the zmol level was demonstrated in this thesis. This method is versatile and can be tailored to detect a variety of targets, such as proteins, coenzymes, nucleotides, and organic molecules.]

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