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Genome Editing in Cardiovascular and Metabolic Diseases

Part of the Advances in Experimental Medicine and Biology Book Series (volume 1396)

Editors: Xiao, Junjie

DOI: 10.1007/978-981-19-5642-3

ISBN: 978-981-19-5641-6

Publisher: Springer Nature Singapore - Springer Journals

Dec 2, 2022

1 - 10 of 20 Chapters

LitStream

An Overview of Genome Editing in Cardiovascular and Metabolic Diseases

Musunuru, Kiran

Pages: 3 –16

[This chapter summarizes the definition, classification, and function of genome editing and highlights the breakthroughs of genome editing in cardiovascular and metabolic diseases for disease modeling, diagnostics, and therapeutics, with a particular focus on clustered regularly interspaced short...
LitStream

Online Databases of Genome Editing in Cardiovascular and Metabolic Diseases

Carrillo-Rodriguez, Paula; Martinez-Lopez, Javier; Gómez-Hernández, Laura; Boraita-Morales, Luis; Uceda-Molina, Maria; Cuenca-Bermejo, Irene; Valencia-Aguirre, Juan P.; Mora-López, Marahy; Plaza-Diaz, Julio

Pages: 19 –33

[Metabolic and cardiovascular diseases are world-concerning pathologies that affect an important percentage of the population. Nowadays, advances in the genetic background of these diseases allow new approaches to models and therapies, as well as different gene edition trials. Furthermore,...
LitStream

Genome Editing and Cardiac Regeneration

Bassawon, Rayhaan; Khan, Kashif; Siddique, Ateeque; Shum-Tim, Dominique

Pages: 37 –52

[Although the field of cardiac regeneration is relatively young, it is progressing rapidly with technological advancements. Genome editing tools are allowing researchers to creatively influence signaling pathways to be able to shed light on them and are important for addressing certain issues and...
LitStream

Genome Editing and Myocardial Development

Turan, Sifa; Chaillet, J. Richard; Stapleton, Margaret C.; Wu, Yijen L.

Pages: 53 –73

[Congenital heart disease (CHD) has a strong genetic etiology, making it a likely candidate for therapeutic intervention using genetic editing. Complex genetics involving an orchestrated series of genetic events and over 400 genes are responsible for myocardial development. Cooperation is...
LitStream

Genome Editing and Heart Failure

Masarone, Daniele; Caiazza, Martina; Amodio, Federica; Melillo, Enrico; Pacileo, Roberta; Limongelli, Giuseppe; Pacileo, Giuseppe

Pages: 75 –85

[Heart failure is a leading and growing cause of morbidity and mortality worldwide and clinically is defined by the presence of typical symptoms and signs due structural or functional cardiac abnormalities. In addition to family history of heart failure, genetic predisposition to cardiomyopathies...
LitStream

Genome Editing and Pathological Cardiac Hypertrophy

Kato, Takao

Pages: 87 –101

[Three major genome editing tools, transcription activator-like effector nucleases (TALENs), zinc finger nucleases (ZFNs), and clustered regularly interspaced short palindromic repeat (CRISPR) systems, are increasingly important technologies used in the study and treatment of hereditary...
LitStream

Genome Editing and Diabetic Cardiomyopathy

Kambis, Tyler N.; Mishra, Paras K.

Pages: 103 –114

[Differential gene expression is associated with diabetic cardiomyopathy (DMCM) and culminates in adverse remodeling in the diabetic heart. Genome editing is a technology utilized to alter endogenous genes. Genome editing also provides an option to induce cardioprotective genes or inhibit genes...
LitStream

Genome Editing and Inherited Cardiac Arrhythmias

Lalaguna, Laura; Ramos-Hernández, Laura; Priori, Silvia G.; Lara-Pezzi, Enrique

Pages: 115 –127

[Inherited arrhythmic disorders are a group of heterogeneous diseases predisposing to life-threatening arrhythmias and sudden cardiac death. Their diagnosis is not always simple due to incomplete penetrance and genetic heterogeneity. Furthermore, the available treatments are usually invasive and...
LitStream

Genome Editing and Atrial Fibrillation

Spartalis, Michael

Pages: 129 –137

[Atrial fibrillation (AF) is a frequent rhythm disturbance that raises the possibility of heart failure (HF) and stroke. AF is a multifactorial disorder combining genetic and environmental etiologies. Over the last decade, advancements have been made regarding the genetic base of this arrhythmia....
LitStream

Genome Editing in Dyslipidemia and Atherosclerosis

Chen, Zhifen; Lehertshuber, Constanze; Schunkert, Heribert

Pages: 139 –156

[Despite successive advancement of genome editing technology with zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), the recent breakthrough in the field has been related to clustered regularly interspaced short palindromic repeats/associated proteins...

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