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Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Part of the Springer Theses Book Series

DOI: 10.1007/978-981-33-6613-8

ISBN: 978-981-33-6612-1

Publisher: Springer Singapore - Springer Journals

Jan 27, 2021

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Chapter 1Introduction

Hu, Kuan

Pages: 1 –24

[Protein-protein interactions (PPIs) play important roles in cell life activities, such as signal transduction, cell cycle, immune system, gene regulation, and so on.]
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Chapter 2Synthesis of In-Tether Chiral Center Peptides and Their Biophysical Properties Study

Hu, Kuan

Pages: 25 –63

[The majority of protein-protein interactions (PPIs) involve α-helices and are usually untreatable with small molecules due to their large interaction areas and shallow surfaces. Therefore, the development of constrained peptides that can modulate PPIs by enhancing the helicity of short peptides...
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Chapter 3In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Cancer Stem Cell

Hu, Kuan

Pages: 65 –99

[Cancer is one of the most formidable diseases to combat. The cancer stem cell (CSC) hypothesis provides a compelling cellular mechanism to account for the therapeutic refractoriness and dormancy in cancer development.]
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Chapter 4Summary and Conclusion

Hu, Kuan

Pages: 101 –102

[Peptide pharmaceuticals has experienced nearly a hundred years of history from the earliest application of bovine insulin to nowadays. Over the past century, with the continuous advancement of peptide synthesis methodology and purification methods, new peptide molecules have entered the medical...

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