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Journal of Gastroenterology

Subject Areas: Gastroenterology
Publisher: Springer Nature Singapore - Springer Journals
ISSN: 0944-1174
SJR: 120

Open Access

Journal Article

Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study

Makuuchi, Motoki; Kakuta, Yoichi; Umeno, Junji; Fujii, Toshimitsu; Takagawa, Tetsuya; Ibuka, Takashi; Miura, Miki; Sasaki, Yu; Takahashi, Sakuma; Nakase, Hiroshi; Kiyohara, Hiroki; Tominaga, Keiichi; Shimodaira, Yosuke; Hiraoka, Sakiko; Ueno, Nobuhiro; Yanai, Shunichi; Yoshihara, Takeo; Kakimoto, Kazuki; Matsuoka, Katsuyoshi; Hayashi, Ryohei; Nanjo, Sohachi; Iwama, Itaru; Ishiguro, Yoh; Chiba, Hirofumi; Endo, Katsuya; Kagaya, Takashi; Fukuda, Tomohiro; Sakata, Yasuhisa; Kudo, Takahiro; Takagi, Tomohisa; Takahashi, Kenichi; Naganuma, Makoto; Shinozaki, Masaru; Ogata, Noriyuki; Tanaka, Hiroki; Narimatsu, Kazuyuki; Miyazaki, Haruka; Ishige, Takashi; Onodera, Motoyuki; Hashimoto, Yu; Nagai, Hiroshi; Shimoyama, Yusuke; Naito, Takeo; Moroi, Rintaro; Shiga, Hisashi; ,; Kinouchi, Yoshitaka; Andoh, Akira; Hisamatsu, Tadakazu; Masamune, Atsushi

2024 Journal of Gastroenterology

doi:10.1007/s00535-024-02099-7 pmid:38589597

BackgroundThis study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) in Japan, using real-world data, and aimed to establish genotype-based treatment strategies.MethodsA retrospective analysis of 4628 IBD patients...
Open Access

Journal Article

The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis

Ampuero, Javier; Aller, Rocío; Gallego-Durán, Rocío; Crespo, Javier; Calleja, Jose Luis; García-Monzón, Carmelo; Gómez-Camarero, Judith; Caballería, Joan; Lo Iacono, Oreste; Ibañez, Luis; García-Samaniego, Javier; Albillos, Agustín; Francés, Rubén; Fernández-Rodríguez, Conrado; Maya-Miles, Douglas; Diago, Moisés; Poca, Maria; Andrade, Raúl J.; Latorre, Raquel; Jorquera, Francisco; Morillas, Rosa María; Escudero, Desamparados; Hernández-Guerra, Manuel; Pareja-Megia, María Jesús; Banales, Jesús M.; Aspichueta, Patricia; Benlloch, Salvador; Rosales, José Miguel; Turnes, Juan; Romero-Gómez, Manuel; ,

2024 Journal of Gastroenterology

doi:10.1007/s00535-024-02098-8 pmid:38619600

BackgroundMASLD can manifest as hepatocellular damage, which can result in mild elevation of aminotransferases. However, in some patients, MASLD presents with cholestatic pattern.ObjectiveTo assess the impact of the biochemical pattern on the natural course of MASLD, including liver damage in...
Open Access

Journal Article

Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma

Fujiwara, Kisako; Kondo, Takayuki; Fujimoto, Kentaro; Yumita, Sae; Ogawa, Keita; Ishino, Takamasa; Nakagawa, Miyuki; Iwanaga, Terunao; Tsuchiya, Satoshi; Koroki, Keisuke; Kanzaki, Hiroaki; Inoue, Masanori; Kobayashi, Kazufumi; Kiyono, Soichiro; Nakamura, Masato; Kanogawa, Naoya; Ogasawara, Sadahisa; Nakamoto, Shingo; Chiba, Tetsuhiro; Koizumi, Jun; Kato, Jun; Kato, Naoya

2024 Journal of Gastroenterology

doi:10.1007/s00535-024-02097-9 pmid:38583112

BackgroundDuring systemic therapy, the management of portal hypertension (PH)-related complications is vital. This study aimed to clarify factors associated with the incidence and exacerbation of PH-related complications, including the usefulness of contrast-enhanced computed tomography (CECT) in...
LitStream

Journal Article

Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation

Uojima, Haruki; Yamasaki, Kazumi; Sugiyama, Masaya; Kage, Masayoshi; Ishii, Norihiro; Shirabe, Ken; Hidaka, Hisashi; Kusano, Chika; Murakawa, Miyako; Asahina, Yasuhiro; Nishimura, Takashi; Iijima, Hiroko; Sakamoto, Kazumasa; Ito, Kiyoaki; Amano, Keisuke; Kawaguchi, Takumi; Tamaki, Nobuharu; Kurosaki, Masayuki; Suzuki, Takanori; Matsuura, Kentaro; Taketomi, Akinobu; Joshita, Satoru; Umemura, Takeji; Nishina, Sohji; Hino, Keisuke; Toyoda, Hidenori; Yatsuhashi, Hiroshi; Mizokami, Masashi

2024 Journal of Gastroenterology

doi:10.1007/s00535-024-02100-3 pmid:38625546

BackgroundThe relationship between liver fibrosis and inflammation and Mac-2-binding protein glycosylation isomer (M2BPGi) in patients with chronic liver disease (CLD) other than hepatitis C remains uncertain, owing to the limitations of qualitative methods. Here, we evaluated the influence of...
LitStream

Journal Article

Natural history of lean and non-lean metabolic dysfunction-associated steatotic liver disease

Wakabayashi, Shun-Ichi; Tamaki, Nobuharu; Kimura, Takefumi; Umemura, Takeji; Kurosaki, Masayuki; Izumi, Namiki

2024 Journal of Gastroenterology

doi:10.1007/s00535-024-02093-z pmid:38570344

BackgroundConflicting evidence regarding the prognosis of lean metabolic dysfunction-associated steatotic liver disease (MASLD) has raised substantial questions.AimThis study aimed to elucidate the prognosis of lean MASLD by conducting a comprehensive analysis of a vast Asian cohort.MethodsThis...
LitStream

Journal Article

Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals

Liu, Chen-Hua; Chang, Yu-Ping; Fang, Yu-Jen; Cheng, Pin-Nan; Chen, Chi-Yi; Kao, Wei-Yu; Lin, Chih-Lin; Yang, Sheng-Shun; Shih, Yu-Lueng; Peng, Cheng-Yuan; Tsai, Ming-Chang; Huang, Shang-Chin; Su, Tung-Hung; Tseng, Tai-Chung; Liu, Chun-Jen; Chen, Pei-Jer; Kao, Jia-Horng

2024 Journal of Gastroenterology

doi:10.1007/s00535-024-02101-2 pmid:38613690

BackgroundInformation on the dynamics of metabolic dysfunction-associated steatotic liver disease (MASLD) among hepatitis C virus patients achieving sustained virologic response (SVR12) with direct-acting antivirals (DAAs) is limited.MethodsWe enrolled 1512 eligible participants in this...

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