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Cell Cycle

Subject Areas: Cell Biology
Publisher: Taylor & Francis - Taylor & Francis
ISSN: 1538-4101
SJR: 157

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Journal Article

SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells

Ma, Rong; Gao, Qing-Yuan; Chen, Zhi-Teng; Liao, Guang-Hong; Li, Shu-Tai; Cai, Jie-Wen; Luo, Nian-Sang; Chen, Hao; Zhang, Hai-Feng

2024 Cell Cycle

doi:10.1080/15384101.2024.2340864 pmid:38626328

The precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration, remain poorly understood. We assessed sirtuins 3 (SIRT3) levels in HCC tissues and Huh7 cells...
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Journal Article

Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth

Wu, Qi; Zheng, Quan; Yuan, Lei; Gao, Dandan; Hu, Yabing; Jiang, Xinqing; Zhai, Qiaocheng; Liu, Ming; Xu, Lifeng; Xu, Heng; Ye, Jinlin; Zhang, Feng

2024 Cell Cycle

doi:10.1080/15384101.2024.2342714 pmid:38619971

Hepatocellular carcinoma (HCC) stands as the third leading cause of cancer-related fatalities globally. In this study, we observed a significant increase in the expression level of the YEATS2 gene in HCC patients, and it is negatively correlated with the patients’ survival rate. While we have...
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Journal Article

Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage

Yamazaki, Kosuke; Iguchi, Tomohiro; Kanoh, Yutaka; Takayasu, Kazuto; Ngo, Trinh Thi To; Onuki, Ayaka; Kawaji, Hideya; Oshima, Shunji; Kanda, Tomomasa; Masai, Hisao; Sasanuma, Hiroyuki

2024 Cell Cycle

doi:10.1080/15384101.2024.2335028 pmid:38571319

Acetaldehyde, a chemical that can cause DNA damage and contribute to cancer, is prevalently present in our environment, e.g. in alcohol, tobacco, and food. Although aldehyde potentially promotes crosslinking reactions among biological substances including DNA, RNA, and protein, it remains...
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Journal Article

Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression

Bundy, J; Shaw, J; Hammel, M; Nguyen, J; Robbins, C; Mercier, I; Suryanarayanan, A

2024 Cell Cycle

doi:10.1080/15384101.2024.2340912 pmid:38623967

Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset. The unresponsiveness to hormone therapies and immunotherapy and the toxicity of chemotherapeutics account for the limited treatment options for TNBC. Ion channels have emerged as possible therapeutic...

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Cell Cycle

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