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As peripheral T‐cell lymphomas (PTCL) are rare and heterogeneous groups of non‐Hodgkin lymphomas, it is practically difficult to conduct randomized controlled trials to establish standard treatment strategies. There is still no consensus regarding the optimal treatment strategy for patients with...
Adoptive therapy with chimeric antigen receptor (CAR)‐modified T cells achieved remissions of so far refractory leukemia/lymphoma; however, the treatment of solid tumors still remains challenging. This is thought to be due to the hostile conditions of the tumor stroma and the repressive immune...
Recently, the anti‐CCR4 antibody mogamulizumab (Moga, Kyowa Hakko Kirin Co., Ltd, Tokyo, Japan) was approved as a treatment for CCR4‐positive adult T‐cell leukemia‐lymphoma (ATL) in Japan. We use Moga before or after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) in patients with...
The ongoing advent of genome editing with programmable nucleases, including zinc‐finger nuclease (ZFN), TAL effector nuclease (TALEN), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)‐associated RNA‐guided endonuclease Cas9 (CRISPR/Cas9), have spurred the hematopoietic stem...
Bone marrow has been a source of nutrition for many centuries. Although xenotransplants were described in an ancient Irish manuscript, it was not until adverse hematological effects of ionizing radiation were known during World War II that the stimulus for bone marrow transplantation was...
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