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Mesenchymal stem/stromal cells (MSCs) infusions are a promising investigational treatment strategy for steroid‐refractory acute graft‐versus‐host disease (GVHD). Herein we describe the rationale for their use in acute GVHD, the clinical data reported from animal and human studies to date, and we...
CD34+ cell enumeration is a critical parameter used to determine the timing of apheresis collections of hematopoietic progenitor cell products (HPC(A)). Automated hematology analyzers equipped with flow cytometry capabilities may be a solution to the problem of limited access to standard flow...
In the early years of hematopoietic cell transplantation (HCT), matching of patients and donors was poorly understood and complications related to genetic (especially HLA) mismatching were profound, resulting in a very high incidence of fatal graft‐versus‐host disease (GVHD). This essentially...
High‐grade B‐cell lymphoma with rearrangement of MYC and BCL2 and/or BCL6 (double‐hit lymphoma: DHL) was newly categorized as a subtype in the 2016 revision of the WHO classification of lymphoid neoplasms. DHL is a rare entity accounting for <10% of DLBCL and clinical data of DHL cases are still...
A meta‐analysis is a statistical analysis that combines the results of multiple scientific studies. After being introduced in the 1970s, meta‐analysis significantly influenced decision making in many scientific disciplines, helping to establish evidence‐based medicine and to resolve seemingly...
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