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Laboratory Diagnostic Systems for Ebola and Marburg Hemorrhagic Fevers Developed with Recombinant Proteins

Laboratory Diagnostic Systems for Ebola and Marburg Hemorrhagic Fevers Developed with Recombinant... Masayuki Saijo,1* Masahiro Niikura,1, Tetsuro Ikegami,1, Ichiro Kurane,1 Takeshi Kurata,2 and Shigeru Morikawa1 Department of Virology 1, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan,1 Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-6840, Japan2 Ebola virus and Marburg virus (EBOV and MARV, respectively) of the family Filoviridae cause hemorrhagic fever with high mortality rates, sometimes reaching 50 to 90% of infected individuals, in humans and nonhuman primates (10, 16, 47). EBOV consists of four species, Zaire EBOV, Sudan EBOV, Ivory Coast EBOV, and Reston EBOV, which were first isolated in the Democratic Republic of Congo, Sudan, Ivory Coast, and the Philippines, respectively (47). MARV consists of one species, Lake Victoria MARV. Public health concerns about filovirus infection have increased in recent years. First, there have recently been large outbreaks of hemorrhagic fevers caused by EBOV (Ebola hemorrhagic fever [EHF]) and MARV (Marburg hemorrhagic fever [MHF]) in Africa; EHF outbreaks occurred in the Democratic Republic of Congo and Uganda in 1995 and 2000, respectively, and MHF outbreaks occurred in the Democratic Republic of Congo in 1998-1999 and in Angola in 2004-2005 (1, 7, 27, 56, 58-60). Second, there is a possibility http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

Laboratory Diagnostic Systems for Ebola and Marburg Hemorrhagic Fevers Developed with Recombinant Proteins

Laboratory Diagnostic Systems for Ebola and Marburg Hemorrhagic Fevers Developed with Recombinant Proteins

Clinical and Vaccine Immunology , Volume 13 (4): 444 – Apr 1, 2006

Abstract

Masayuki Saijo,1* Masahiro Niikura,1, Tetsuro Ikegami,1, Ichiro Kurane,1 Takeshi Kurata,2 and Shigeru Morikawa1 Department of Virology 1, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan,1 Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-6840, Japan2 Ebola virus and Marburg virus (EBOV and MARV, respectively) of the family Filoviridae cause hemorrhagic fever with high mortality rates, sometimes reaching 50 to 90% of infected individuals, in humans and nonhuman primates (10, 16, 47). EBOV consists of four species, Zaire EBOV, Sudan EBOV, Ivory Coast EBOV, and Reston EBOV, which were first isolated in the Democratic Republic of Congo, Sudan, Ivory Coast, and the Philippines, respectively (47). MARV consists of one species, Lake Victoria MARV. Public health concerns about filovirus infection have increased in recent years. First, there have recently been large outbreaks of hemorrhagic fevers caused by EBOV (Ebola hemorrhagic fever [EHF]) and MARV (Marburg hemorrhagic fever [MHF]) in Africa; EHF outbreaks occurred in the Democratic Republic of Congo and Uganda in 1995 and 2000, respectively, and MHF outbreaks occurred in the Democratic Republic of Congo in 1998-1999 and in Angola in 2004-2005 (1, 7, 27, 56, 58-60). Second, there is a possibility

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Publisher
American Society For Microbiology
Copyright
Copyright © 2006 by the American Society For Microbiology.
ISSN
1556-6811
eISSN
1556-6811
DOI
10.1128/CVI.13.4.444-451.2006
Publisher site
See Article on Publisher Site

Abstract

Masayuki Saijo,1* Masahiro Niikura,1, Tetsuro Ikegami,1, Ichiro Kurane,1 Takeshi Kurata,2 and Shigeru Morikawa1 Department of Virology 1, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan,1 Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-6840, Japan2 Ebola virus and Marburg virus (EBOV and MARV, respectively) of the family Filoviridae cause hemorrhagic fever with high mortality rates, sometimes reaching 50 to 90% of infected individuals, in humans and nonhuman primates (10, 16, 47). EBOV consists of four species, Zaire EBOV, Sudan EBOV, Ivory Coast EBOV, and Reston EBOV, which were first isolated in the Democratic Republic of Congo, Sudan, Ivory Coast, and the Philippines, respectively (47). MARV consists of one species, Lake Victoria MARV. Public health concerns about filovirus infection have increased in recent years. First, there have recently been large outbreaks of hemorrhagic fevers caused by EBOV (Ebola hemorrhagic fever [EHF]) and MARV (Marburg hemorrhagic fever [MHF]) in Africa; EHF outbreaks occurred in the Democratic Republic of Congo and Uganda in 1995 and 2000, respectively, and MHF outbreaks occurred in the Democratic Republic of Congo in 1998-1999 and in Angola in 2004-2005 (1, 7, 27, 56, 58-60). Second, there is a possibility

Journal

Clinical and Vaccine ImmunologyAmerican Society For Microbiology

Published: Apr 1, 2006

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