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- Publisher
- Annual Reviews
- Copyright
- Copyright © 2016 by Annual Reviews. All rights reserved
- ISSN
- 0066-4197
- eISSN
- 1545-2948
- DOI
- 10.1146/annurev-genet-120215-035043
- pmid
- 27732795
- Publisher site
- See Article on Publisher Site
Abstract
Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of our understanding of these pathways has come from the analysis of site-specific DSBs created by the HO endonuclease in the budding yeast Saccharomyces cerevisiae . I was fortunate to get in on the ground floor of analyzing the fate of synchronously induced DSBs through the study of what I coined “in vivo biochemistry.” I have had the remarkable good fortune to profit from the development of new techniques that have permitted an ever more detailed dissection of these repair mechanisms, which are described here.
Journal
Annual Review of Genetics – Annual Reviews
Published: Nov 23, 2016