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Chemical and Biological Dynamics Using Droplet-Based Microfluidics

Chemical and Biological Dynamics Using Droplet-Based Microfluidics Recent years have witnessed an increased use of droplet-based microfluidic techniques in a wide variety of chemical and biological assays. Nevertheless, obtaining dynamic data from these platforms has remained challenging, as this often requires reading the same droplets (possibly thousands of them) multiple times over a wide range of intervals (from milliseconds to hours). In this review, we introduce the elemental techniques for the formation and manipulation of microfluidic droplets, together with the most recent developments in these areas. We then discuss a wide range of analytical methods that have been successfully adapted for analyte detection in droplets. Finally, we highlight a diversity of studies where droplet-based microfluidic strategies have enabled the characterization of dynamic systems that would otherwise have remained unexplorable. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Analytical Chemistry Annual Reviews

Chemical and Biological Dynamics Using Droplet-Based Microfluidics

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References (133)

Publisher
Annual Reviews
Copyright
Copyright © 2017 by Annual Reviews. All rights reserved
ISSN
1936-1327
eISSN
1936-1335
DOI
10.1146/annurev-anchem-061516-045219
pmid
28375703
Publisher site
See Article on Publisher Site

Abstract

Recent years have witnessed an increased use of droplet-based microfluidic techniques in a wide variety of chemical and biological assays. Nevertheless, obtaining dynamic data from these platforms has remained challenging, as this often requires reading the same droplets (possibly thousands of them) multiple times over a wide range of intervals (from milliseconds to hours). In this review, we introduce the elemental techniques for the formation and manipulation of microfluidic droplets, together with the most recent developments in these areas. We then discuss a wide range of analytical methods that have been successfully adapted for analyte detection in droplets. Finally, we highlight a diversity of studies where droplet-based microfluidic strategies have enabled the characterization of dynamic systems that would otherwise have remained unexplorable.

Journal

Annual Review of Analytical ChemistryAnnual Reviews

Published: Jun 12, 2017

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