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Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications

Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications A major branch of glycobiology and glycan-focused biomedicine studies the interaction between carbohydrates and other biopolymers, most importantly, glycan-binding proteins. Today, this research into glycan-biopolymer interaction is unthinkable without glycan arrays, tools that enable high-throughput analysis of carbohydrate interaction partners. Glycan arrays offer many applications in basic biochemical research, for example, defining the specificity of glycosyltransferases and lectins such as immune receptors. Biomedical applications include the characterization and surveillance of influenza strains, identification of biomarkers for cancer and infection, and profiling of immune responses to vaccines. Here, we review major applications of glycan arrays both in basic and applied research. Given the dynamic nature of this rapidly developing field, we focus on recent findings. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Analytical Chemistry Annual Reviews

Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications

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Publisher
Annual Reviews
Copyright
Copyright © 2016 by Annual Reviews. All rights reserved
ISSN
1936-1327
eISSN
1936-1335
DOI
10.1146/annurev-anchem-071015-041641
pmid
27306309
Publisher site
See Article on Publisher Site

Abstract

A major branch of glycobiology and glycan-focused biomedicine studies the interaction between carbohydrates and other biopolymers, most importantly, glycan-binding proteins. Today, this research into glycan-biopolymer interaction is unthinkable without glycan arrays, tools that enable high-throughput analysis of carbohydrate interaction partners. Glycan arrays offer many applications in basic biochemical research, for example, defining the specificity of glycosyltransferases and lectins such as immune receptors. Biomedical applications include the characterization and surveillance of influenza strains, identification of biomarkers for cancer and infection, and profiling of immune responses to vaccines. Here, we review major applications of glycan arrays both in basic and applied research. Given the dynamic nature of this rapidly developing field, we focus on recent findings.

Journal

Annual Review of Analytical ChemistryAnnual Reviews

Published: Jun 12, 2016

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