Access the full text.
Sign up today, get DeepDyve free for 14 days.
Na Mi, Yang Chen, Shuai Wang, Mengran Chen, M. Zhao, Guang Yang, M. Ma, Q. Su, S. Luo, Jingwen Shi, Jia Xu, Q. Guo, N. Gao, Yujie Sun, Zhucheng Chen, Li Yu (2015)
CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membraneNature Cell Biology, 17
T. Sekito, Tomoko Kawamata, R. Ichikawa, Kuninori Suzuki, Y. Ohsumi (2009)
Atg17 recruits Atg9 to organize the pre‐autophagosomal structureGenes to Cells, 14
J. Stack, D. Dewald, K. Takegawa, S. Emr (1995)
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeastThe Journal of Cell Biology, 129
I. Ganley, Du Lam, Junru Wang, Xiaojun Ding, She Chen, Xuejun Jiang (2009)
ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy*Journal of Biological Chemistry, 284
Hironori Suzuki, T. Osawa, Y. Fujioka, N. Noda (2017)
Structural biology of the core autophagy machinery.Current opinion in structural biology, 43
L. Bar-Peled, D. Sabatini (2014)
Regulation of mTORC1 by amino acids.Trends in cell biology, 24 7
Chin-Chih Liu, Yu-Ching Lin, Yu-Hsuan Chen, Chun-Ming Chen, Liang-Yu Pang, Hsuan-An Chen, Pei-Rung Wu, M. Lin, Si-Tse Jiang, T. Tsai, Ruey-Hwa Chen (2016)
Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.Molecular cell, 61 1
Yu Zhong, Deanna Morris, Lin Jin, Mittul Patel, Senthil Karunakaran, You-Jun Fu, Emily Matuszak, H. Weiss, B. Chait, Qing Wang (2014)
Title: Nrbf2 Suppresses Autophagy by Modulating Atg14L-containing Beclin 1-Vps34 Protein Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels
Juan Wang, Shekar Menon, A. Yamasaki, H. Chou, T. Walz, Yu Jiang, S. Ferro-Novick (2013)
Ypt1 recruits the Atg1 kinase to the preautophagosomal structureProceedings of the National Academy of Sciences, 110
Y. Kamada, T. Funakoshi, T. Shintani, K. Nagano, M. Ohsumi, Y. Ohsumi (2000)
Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase ComplexThe Journal of Cell Biology, 150
Daniel Papinski, C. Kraft (2016)
Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex.Journal of molecular biology, 428 9 Pt A
Kanae Shirahama‐Noda, S. Kira, T. Yoshimori, T. Noda (2013)
TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagyJournal of Cell Science, 126
Mary Lin, J. Hurley (2016)
Structure and function of the ULK1 complex in autophagy.Current opinion in cell biology, 39
Y. Araki, W. Ku, Manami Akioka, Alexander May, Yuko Hayashi, F. Arisaka, Y. Ishihama, Y. Ohsumi (2013)
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrityThe Journal of Cell Biology, 203
H. Cheong, Tomohiro Yorimitsu, F. Reggiori, Julie Legakis, Chao-Wen Wang, D. Klionsky (2005)
Atg17 regulates the magnitude of the autophagic response.Molecular biology of the cell, 16 7
Päivi Ylä-Anttila, H. Vihinen, E. Jokitalo, E. Eskelinen (2009)
3D tomography reveals connections between the phagophore and endoplasmic reticulumAutophagy, 5
S. Vanni, Lydie Vamparys, R. Gautier, G. Drin, C. Etchebest, P. Fuchs, B. Antonny (2013)
Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues.Biophysical journal, 104 3
Max Michel, M. Schwarten, Christina Decker, L. Nagel-Steger, D. Willbold, O. Weiergräber (2015)
The mammalian autophagy initiator complex contains 2 HORMA domain proteinsAutophagy, 11
Thomas Lang, Steffen Reiche, M. Straub, Monika Bredschneider, M. Thumm (2000)
Autophagy and the cvt Pathway Both Depend onAUT9Journal of Bacteriology, 182
Johanna Kondelin, Kari Salokas, L. Saarinen, K. Ovaska, Heli Rauanheimo, Roosa-Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, A. Gylfe, Tatiana Cajuso, U. Hänninen, Kimmo Palin, H. Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, M. Aavikko, Minna Taipale, J. Taipale, L. Renkonen-Sinisalo, A. Lepistö, S. Koskensalo, J. Böhm, J. Mecklin, H. Ongen, E. Dermitzakis, O. Kilpivaara, P. Vahteristo, Mikko Turunen, S. Hautaniemi, S. Tuupanen, A. Karhu, Niko Välimäki, M. Varjosalo, E. Pitkänen, L. Aaltonen (2018)
Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancerEMBO Molecular Medicine, 10
N. Hieke, Antje Löffler, T. Kaizuka, N. Berleth, P. Böhler, Stefan Driessen, Fabian Stuhldreier, Olena Friesen, Kaivon Assani, Katharina Schmitz, C. Peter, B. Diedrich, J. Dengjel, Petter Holland, A. Simonsen, S. Wesselborg, N. Mizushima, B. Stork (2015)
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cellsAutophagy, 11
D. Tan, Yiying Cai, Juan Wang, Jinzhong Zhang, Shekar Menon, H. Chou, S. Ferro-Novick, K. Reinisch, T. Walz (2013)
The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathwayProceedings of the National Academy of Sciences, 110
Edmond Chan, A. Longatti, Nicole McKnight, S. Tooze (2008)
Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent MechanismMolecular and Cellular Biology, 29
Eleftherios Karanasios, Simon Walker, H. Okkenhaug, M. Manifava, Eric Hummel, Hans Zimmermann, Qashif Ahmed, M. Domart, Lucy Collinson, N. Ktistakis (2016)
Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesiclesNature Communications, 7
Jia-Hong Lu, Jia-Hong Lu, Liqiang He, C. Behrends, M. Araki, K. Araki, Qing Wang, Joseph Catanzaro, S. Friedman, W. Zong, M. Fiel, Min Li, Zhenyu Yue (2014)
NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Atg14L-Linked Phosphatidylinositol-3 Kinase III ActivityNature communications, 5
E. Alemu, T. Lamark, K. Torgersen, Aasa Birgisdottir, K. Larsen, Ashish Jain, H. Olsvik, Aud Øvervatn, V. Kirkin, T. Johansen (2012)
ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK ComplexThe Journal of Biological Chemistry, 287
Lindsey Young, K. Cho, R. Lawrence, R. Zoncu, J. Hurley (2016)
Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagyProceedings of the National Academy of Sciences, 113
Weijiao Huang, W. Choi, Wanqiu Hu, Na Mi, Q. Guo, M. Ma, Mei Liu, Yuan Tian, P. Lu, Feng-Liang Wang, Haiteng Deng, Lei Liu, N. Gao, Li Yu, Yigong Shi (2012)
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding proteinCell Research, 22
Y. Ohashi, N. Soler, Miguel Ortegón, Lufei Zhang, M. Kirsten, O. Perisic, G. Masson, J. Burke, A. Jakobi, A. Apostolakis, Christopher Johnson, M. Ohashi, N. Ktistakis, C. Sachse, Roger Williams (2016)
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complexAutophagy, 12
Y. Rao, Marco Perna, B. Hofmann, Viola Beier, T. Wollert (2016)
The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagyNature Communications, 7
G. Drin, J. Casella, R. Gautier, Thomas Boehmer, T. Schwartz, B. Antonny (2007)
A general amphipathic α-helical motif for sensing membrane curvatureNature Structural &Molecular Biology, 14
J. Mancias, Alec Kimmelman (2016)
Mechanisms of Selective Autophagy in Normal Physiology and Cancer.Journal of molecular biology, 428 9 Pt A
Justyna Sawa-Makarska, C. Abert, J. Romanov, Bettina Zens, Iosune Ibiricu, Sascha Martens (2014)
Cargo binding to Atg19 unmasks further Atg8 binding sites to mediate membrane-cargo apposition during selective autophagyNature cell biology, 16
M. Lazarus, C. Novotny, K. Shokat (2014)
Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent InhibitorsACS Chemical Biology, 10
Wen-Ying Wu, Weili Tian, Zhe Hu, Guo Chen, Lei Huang, Wen Li, Xingliang Zhang, Peng Xue, Changqian Zhou, Lei Liu, Yushan Zhu, Xingliang Zhang, Longxuan Li, Liangqing Zhang, Senfang Sui, Bin Zhao, Du Feng (2014)
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagyEMBO reports, 15
Christopher Lamb, Stefanie Nühlen, Delphine Judith, D. Frith, A. Snijders, Christian Behrends, S. Tooze (2015)
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 trafficThe EMBO Journal, 35
K. Matsunaga, T. Saitoh, Keisuke Tabata, H. Omori, T. Satoh, Naoki Kurotori, Ikuko Maejima, Kanae Shirahama‐Noda, T. Ichimura, T. Isobe, S. Akira, T. Noda, T. Yoshimori (2009)
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stagesNature Cell Biology, 11
J. Hurley, E. Nogales (2016)
Next-generation electron microscopy in autophagy research.Current opinion in structural biology, 41
Juan Wang, S. Davis, Shekar Menon, Jinzhong Zhang, Jingzhen Ding, Serena Cervantes, E. Miller, Yu Jiang, S. Ferro-Novick (2015)
Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER–Golgi traffic and macroautophagyThe Journal of Cell Biology, 210
K. Rostislavleva, N. Soler, Y. Ohashi, Lufei Zhang, E. Pardon, J. Burke, G. Masson, Chris Johnson, J. Steyaert, N. Ktistakis, Roger Williams (2015)
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranesScience, 350
Hayashi Yamamoto, Y. Fujioka, Sho Suzuki, D. Noshiro, Hironori Suzuki, Chika Kondo-Kakuta, Y. Kimura, H. Hirano, T. Ando, N. Noda, Y. Ohsumi (2016)
The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.Developmental cell, 38 1
Y. Kabeya, N. Noda, Y. Fujioka, Kuninori Suzuki, F. Inagaki, Y. Ohsumi (2009)
Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.Biochemical and biophysical research communications, 389 4
A. Orsi, M. Razi, H. Dooley, D. Robinson, A. Weston, L. Collinson, S. Tooze (2012)
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagyMolecular Biology of the Cell, 23
F. Brandizzi, C. Barlowe (2013)
Organization of the ER–Golgi interface for membrane traffic controlNature Reviews Molecular Cell Biology, 14
Eisuke Itakura, C. Kishi, Kinji Inoue, N. Mizushima (2008)
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.Molecular biology of the cell, 19 12
J. Backer (2016)
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.The Biochemical journal, 473 15
Tomohiro Yorimitsu, D. Klionsky (2005)
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.Molecular biology of the cell, 16 4
Chao-Wen Wang, John Kim, Wei‐Pang Huang, H. Abeliovich, P. Strømhaug, W. Dunn, D. Klionsky (2001)
Apg2 Is a Novel Protein Required for the Cytoplasm to Vacuole Targeting, Autophagy, and Pexophagy Pathways*The Journal of Biological Chemistry, 276
Molly Lynch-Day, Deepali Bhandari, Shekar Menon, Ju Huang, H. Cai, Clinton Bartholomew, J. Brumell, S. Ferro-Novick, D. Klionsky (2010)
Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagyProceedings of the National Academy of Sciences, 107
N. Mizushima, M. Komatsu (2011)
Autophagy: Renovation of Cells and TissuesCell, 147
Hai‐Xin Yuan, R. Russell, K. Guan (2013)
Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagyAutophagy, 9
S. Bartolomeo, M. Corazzari, F. Nazio, S. Oliverio, G. Lisi, M. Antonioli, Vittoria Pagliarini, S. Matteoni, C. Fuoco, Luigi Giunta, M. D’Amelio, R. Nardacci, A. Romagnoli, M. Piacentini, F. Cecconi, G. Fimia (2010)
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagyThe Journal of Cell Biology, 191
Xin Wen, D. Klionsky (2016)
An overview of macroautophagy in yeast.Journal of molecular biology, 428 9 Pt A
Liang Ge, D. Melville, M. Zhang, R. Schekman (2013)
The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesiseLife, 2
T. Shintani, K. Suzuki, Y. Kamada, Takeshi Noda, Y. Ohsumi (2001)
Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure*The Journal of Biological Chemistry, 276
E. Axe, Simon Walker, M. Manifava, Priya Chandra, H. Roderick, Anja Habermann, Gareth ths, N. Ktistakis
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Jürgen Köfinger, M. Ragusa, Il-Hyung Lee, G. Hummer, J. Hurley (2015)
Solution structure of the Atg1 complex: implications for the architecture of the phagophore assembly site.Structure, 23 5
S. Baskaran, L. Carlson, Goran Stjepanovic, Lindsey Young, Do Kim, Patricia Grob, R. Stanley, E. Nogales, J. Hurley (2014)
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complexeLife, 3
M. Kijanska, I. Dohnal, W. Reiter, S. Kaspar, Ingrid Stoffel, G. Ammerer, C. Kraft, M. Peter (2010)
Activation of Atg1 kinase in autophagy by regulated phosphorylationAutophagy, 6
Liang Ge, S. Baskaran, R. Schekman, J. Hurley (2014)
The protein-vesicle network of autophagy.Current opinion in cell biology, 29
S. Kametaka, Takafumi Okano, M. Ohsumi, Y. Ohsumi (1998)
Apg14p and Apg6/Vps30p Form a Protein Complex Essential for Autophagy in the Yeast, Saccharomyces cerevisiae *The Journal of Biological Chemistry, 273
Naoko Hosokawa, Taichi Hara, T. Kaizuka, C. Kishi, A. Takamura, Yutaka Miura, S. Iemura, T. Natsume, K. Takehana, Naoyuki Yamada, J. Guan, N. Oshiro, N. Mizushima (2009)
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.Molecular biology of the cell, 20 7
S. Pattingre, Amina Tassa, X. Qu, R. Garuti, X. Liang, N. Mizushima, M. Packer, M. Schneider, B. Levine (2005)
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent AutophagyCell, 122
Einat Zalckvar, H. Berissi, Liat Mizrachy, Yulia Idelchuk, Itay Koren, M. Eisenstein, H. Sabanay, R. Pinkas-Kramarski, A. Kimchi (2009)
DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagyEMBO reports, 10
Yongjie Wei, Z. Zou, Nils Becker, Matthew Anderson, R. Sumpter, Guanghua Xiao, L. Kinch, P. Koduru, Christhunesa Christudass, R. Veltri, N. Grishin, M. Peyton, J. Minna, G. Bhagat, B. Levine (2013)
EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor ChemoresistanceCell, 154
Taichi Hara, A. Takamura, C. Kishi, S. Iemura, T. Natsume, J. Guan, N. Mizushima (2008)
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cellsThe Journal of Cell Biology, 181
Eisuke Itakura, Chieko Kishi-Itakura, Ikuko Koyama-Honda, N. Mizushima (2012)
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagyJournal of Cell Science, 125
Christian Behrends, M. Sowa, S. Gygi, J. Harper (2010)
Network organization of the human autophagy systemNature, 466
E. Heenan, J. Vanhooke, B. Temple, L. Betts, J. Sondek, H. Dohlman (2009)
Structure and function of Vps15 in the endosomal G protein signaling pathway.Biochemistry, 48 27
Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen, A. Tito, G. David, Yamin Sun, E. Stimming, H. Bellen, A. Cuervo, S. Zhang (2015)
Huntingtin Functions as a Scaffold for Selective MacroautophagyNature cell biology, 17
N. Ktistakis, Simon Andrews, Joshua Long (2008)
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulumThe Journal of Cell Biology, 182
Yuh-Ying Yeh, Kristie Wrasman, P. Herman (2010)
Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiaeGenetics, 185
L. Galluzzi, F. Pietrocola, J. Pedro, R. Amaravadi, E. Baehrecke, F. Cecconi, P. Codogno, Jayanta Debnath, D. Gewirtz, V. Karantza, Alec Kimmelman, Sharad Kumar, B. Levine, M. Maiuri, Seamus Martin, J. Penninger, M. Piacentini, D. Rubinsztein, H. Simon, A. Simonsen, A. Thorburn, G. Velasco, K. Ryan, G. Kroemer (2015)
Autophagy in malignant transformation and cancer progressionThe EMBO Journal, 34
H. Abeliovich, Chao Zhang, W. Dunn, K. Shokat, D. Klionsky (2003)
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy.Molecular biology of the cell, 14 2
M. Graef, J. Friedman, Chris Graham, M. Babu, J. Nunnari (2013)
ER exit sites are physical and functional core autophagosome biogenesis componentsMolecular Biology of the Cell, 24
Nobuyuki Fujiwara, T. Usui, T. Ohama, Koichi Sato (2016)
Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3)*The Journal of Biological Chemistry, 291
C. Jao, M. Ragusa, R. Stanley, J. Hurley (2013)
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagyProceedings of the National Academy of Sciences, 110
Congcong He, M. Baba, Yang Cao, D. Klionsky (2008)
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy.Molecular biology of the cell, 19 12
Xiaohua Li, Liqiang He, K. Che, Sarah Funderburk, L. Pan, Nina Pan, Mingjie Zhang, Zhenyu Yue, Yanxiang Zhao (2012)
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAGNature Communications, 3
Weiliang Fan, A. Nassiri, Q. Zhong (2011)
Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)Proceedings of the National Academy of Sciences, 108
J. Hurley, B. Schulman (2014)
Atomistic Autophagy: The Structures of Cellular Self-DigestionCell, 157
M. Ragusa, R. Stanley, J. Hurley (2012)
Architecture of the Atg17 Complex as a Scaffold for Autophagosome BiogenesisCell, 151
Simon Miller, Brandon Tavshanjian, A. Oleksy, O. Perisic, B. Houseman, K. Shokat, Roger Williams (2010)
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34Science, 327
J. Joo, Bo Wang, E. Frankel, Liang Ge, Lu Xu, R. Iyengar, Xiujie Li-Harms, Christopher Wright, T. Shaw, T. Lindsten, D. Green, Junmin Peng, L. Hendershot, F. Kilic, J. Sze, A. Audhya, M. Kundu (2016)
The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.Molecular cell, 62 4
J. Biazik, Päivi Ylä-Anttila, H. Vihinen, E. Jokitalo, E. Eskelinen (2015)
Ultrastructural relationship of the phagophore with surrounding organellesAutophagy, 11
K. Obara, T. Sekito, Y. Ohsumi (2006)
Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae.Molecular biology of the cell, 17 4
C. Puri, Maurizio Renna, Carla Bento, K. Moreau, D. Rubinsztein (2013)
Diverse Autophagosome Membrane Sources Coalesce in Recycling EndosomesCell, 154
A. Young, Edmond Chan, X. Hu, Robert Köchl, Samuel Crawshaw, S. High, D. Hailey, J. Lippincott-Schwartz, S. Tooze (2006)
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomesJournal of Cell Science, 119
Hayashi Yamamoto, S. Kakuta, Tomonobu Watanabe, Akira Kitamura, T. Sekito, Chika Kondo-Kakuta, R. Ichikawa, M. Kinjo, Y. Ohsumi (2012)
Atg9 vesicles are an important membrane source during early steps of autophagosome formationThe Journal of Cell Biology, 198
N. Mizushima (2010)
The role of the Atg1/ULK1 complex in autophagy regulation.Current opinion in cell biology, 22 2
Yongjie Wei, Zhenyi An, Z. Zou, R. Sumpter, M. Su, Xiao Zang, Sangita Sinha, M. Gaestel, B. Levine (2015)
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylationeLife, 4
Y. Kabeya, Y. Kamada, M. Baba, H. Takikawa, M. Sasaki, Y. Ohsumi (2005)
Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy.Molecular biology of the cell, 16 5
Daniel Egan, D. Shackelford, M. Mihaylova, Sara Gelino, Rebecca Kohnz, William Mair, Debbie Vasquez, Aashish Joshi, Dana Gwinn, Rebecca Taylor, J. Asara, J. Fitzpatrick, A. Dillin, B. Viollet, M. Kundu, M. Hansen, R. Shaw (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to MitophagyScience, 331
Daniel Egan, M. Chun, Mitchell Vamos, Haixia Zou, Juan Rong, Chad Miller, H. Lou, Dhanya Raveendra-Panickar, chih‐cheng yang, D. Sheffler, P. Teriete, J. Asara, B. Turk, N. Cosford, R. Shaw (2015)
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.Molecular cell, 59 2
K. Suzuki, T. Kirisako, Y. Kamada, N. Mizushima, Takeshi Noda, Y. Ohsumi (2001)
The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formationThe EMBO Journal, 20
Y. Zhong, Qing Wang, Xianting Li, Ying Yan, J. Backer, B. Chait, N. Heintz, Zhenyu Yue (2009)
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complexNature Cell Biology, 11
Daniela Stadel, Valentina Millarte, Kerstin Tillmann, J. Huber, Bat-Chen Tamin-Yecheskel, M. Akutsu, Alik Demishtein, B. Ben-Zeev, Y. Anikster, F. Perez, V. Dötsch, Z. Elazar, V. Rogov, H. Farhan, C. Behrends (2015)
TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.Molecular cell, 60 1
K. Moreau, Maurizio Renna, D. Rubinsztein (2013)
Connections between SNAREs and autophagy.Trends in biochemical sciences, 38 2
Takeshi Noda, John Kim, Wei‐Pang Huang, M. Baba, Chikara Tokunaga, Y. Ohsumi, D. Klionsky (2000)
Apg9p/Cvt7p Is an Integral Membrane Protein Required for Transport Vesicle Formation in the Cvt and Autophagy PathwaysThe Journal of Cell Biology, 148
Goran Stjepanovic, C. Davies, R. Stanley, M. Ragusa, Do Kim, J. Hurley (2014)
Assembly and dynamics of the autophagy-initiating Atg1 complexProceedings of the National Academy of Sciences, 111
M. Mihaylova, R. Shaw (2011)
The AMPK signalling pathway coordinates cell growth, autophagy and metabolismNature Cell Biology, 13
Daniel Egan, Joungmok Kim, R. Shaw, K. Guan (2011)
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTORAutophagy, 7
N. Noda, Takafumi Kobayashi, Wakana Adachi, Y. Fujioka, Y. Ohsumi, F. Inagaki (2012)
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy*The Journal of Biological Chemistry, 287
L. Shang, She Chen, Fenghe Du, Shen Li, Liping Zhao, Xiaodong Wang (2011)
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPKProceedings of the National Academy of Sciences, 108
R. Russell, Ye Tian, Hai‐Xin Yuan, H. Park, Yu-Yun Chang, Joungmok Kim, Haerin Kim, T. Neufeld, A. Dillin, K. Guan (2013)
ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinaseNature cell biology, 15
Junghyun Lim, M. Lachenmayer, Shuai Wu, Wenchao Liu, M. Kundu, Rong Wang, M. Komatsu, Young Oh, Yanxiang Zhao, Zhenyu Yue (2015)
Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein AggregatesPLoS Genetics, 11
F. Reggiori, K. Tucker, P. Strømhaug, D. Klionsky (2004)
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.Developmental cell, 6 1
A. Kihara, Takeshi Noda, Naotada Ishihara, Y. Ohsumi (2001)
Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiaeThe Journal of Cell Biology, 152
C. Kraft, M. Kijanska, Eyal Kalie, E. Siergiejuk, Sung Lee, Giuseppe Semplicio, Ingrid Stoffel, Andrea Brezovich, Mayanka Verma, I. Hansmann, G. Ammerer, K. Hofmann, S. Tooze, M. Peter (2012)
Binding of the Atg1/ULK1 kinase to the ubiquitin‐like protein Atg8 regulates autophagyThe EMBO Journal, 31
Bettina Wurzer, Gabriele Zaffagnini, Dorotea Fracchiolla, E. Turco, C. Abert, J. Romanov, Sascha Martens (2015)
Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagyeLife, 4
Mitsuko Hayashi-Nishino, Naonobu Fujita, T. Noda, A. Yamaguchi, T. Yoshimori, A. Yamamoto (2009)
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formationNature Cell Biology, 11
Gabriele Zaffagnini, Sascha Martens (2016)
Mechanisms of Selective AutophagyJournal of Molecular Biology, 428
Joungmok Kim, Young Kim, C. Fang, R. Russell, J. Kim, Weiliang Fan, Rong Liu, Q. Zhong, K. Guan (2013)
Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and AutophagyCell, 152
Yanyan Cao, Yichen Wang, W. Saab, Fajun Yang, J. Pessin, J. Backer (2014)
NRBF2 regulates macroautophagy as a component of Vps34 Complex I.The Biochemical journal, 461 2
Joungmok Kim, M. Kundu, B. Viollet, K. Guan (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Nature Cell Biology, 13
Hironori Suzuki, T. Kaizuka, N. Mizushima, N. Noda (2015)
Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiationNature Structural &Molecular Biology, 22
S. Kakuta, Hayashi Yamamoto, L. Negishi, Chika Kondo-Kakuta, N. Hayashi, Y. Ohsumi (2012)
Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site*The Journal of Biological Chemistry, 287
S. Shaid, C. Brandts, H. Serve, I. Dikič (2012)
Ubiquitination and selective autophagyCell Death and Differentiation, 20
S. Alers, Antje Löffler, Florian Paasch, Alexandra Dieterle, H. Keppeler, K. Lauber, D. Campbell, B. Fehrenbacher, M. Schaller, S. Wesselborg, B. Stork (2011)
Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy inductionAutophagy, 7
N. Mizushima, T. Yoshimori, Y. Ohsumi (2011)
The role of Atg proteins in autophagosome formation.Annual review of cell and developmental biology, 27
Y. Fujioka, Sho Suzuki, Hayashi Yamamoto, Chika Kondo-Kakuta, Y. Kimura, H. Hirano, R. Akada, F. Inagaki, Y. Ohsumi, N. Noda (2014)
Structural basis of starvation-induced assembly of the autophagy initiation complexNature Structural &Molecular Biology, 21
Yu Zhong, Deanna Morris, Lin Jin, Mittul Patel, Senthil Karunakaran, You-Jun Fu, Emily Matuszak, H. Weiss, B. Chait, Qing Wang (2014)
Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels*The Journal of Biological Chemistry, 289
E. Armstrong (1944)
Annual Review of BiochemistryNature, 154
Daniel Papinski, Martina Schuschnig, W. Reiter, Larissa Wilhelm, C. Barnes, A. Maiolica, I. Hansmann, Thaddaeus Pfaffenwimmer, M. Kijanska, Ingrid Stoffel, Sung Lee, Andrea Brezovich, Jane Lou, B. Turk, R. Aebersold, G. Ammerer, M. Peter, C. Kraft (2014)
Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 KinaseMolecular Cell, 53
M. Mari, Janice Griffith, E. Rieter, Lakshmi Krishnappa, D. Klionsky, F. Reggiori (2010)
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesisThe Journal of Cell Biology, 190
Roarke Kamber, Christopher Shoemaker, Vladimir Denic (2015)
Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase.Molecular cell, 59 3
Dandan Xu, Zheng-Wu Wang, Chen-yao Wang, Desheng Zhang, Huishi Wan, Ziming Zhao, Jin Gu, Yongxian Zhang, Zhigang Li, Kaiyang Man, Yi Pan, Zhi‐Fei Wang, Z. Ke, Zhi‐Xue Liu, Lu-Jian Liao, Yan Chen (2016)
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activityThe EMBO Journal, 35
Richard Wang, Yongjie Wei, Zhenyi An, Z. Zou, Guanghua Xiao, G. Bhagat, Michael White, J. Reichelt, B. Levine (2012)
Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 PhosphorylationScience, 338
Y. Kamada, K. Yoshino, Chika Kondo, Tomoko Kawamata, N. Oshiro, K. Yonezawa, Y. Ohsumi (2009)
Tor Directly Controls the Atg1 Kinase Complex To Regulate AutophagyMolecular and Cellular Biology, 30
L. Lemus, Juan Ribas, N. Sikorska, V. Goder (2016)
An ER-Localized SNARE Protein Is Exported in Specific COPII Vesicles for Autophagosome Biogenesis.Cell reports, 14 7
S. Qi, Do Kim, Goran Stjepanovic, J. Hurley (2015)
Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.Structure, 23 10
M. Faini, R. Beck, F. Wieland, J. Briggs (2013)
Vesicle coats: structure, function, and general principles of assembly.Trends in cell biology, 23 6
Hildegard Mack, Bin Zheng, J. Asara, Sheila Thomas (2012)
AMPK-dependent phosphorylation of ULK1 regulates ATG9 localizationAutophagy, 8
M. Bach, M. Larance, D. James, G. Ramm (2011)
The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.The Biochemical journal, 440 2
Usha Nair, Anjali Jotwani, Jiefei Geng, N. Gammoh, Diana Richerson, Wei-Lien Yen, Janice Griffith, Shanta Nag, Ke Wang, Tyler Moss, M. Baba, J. McNew, Xuejun Jiang, F. Reggiori, T. Melia, D. Klionsky (2011)
SNARE Proteins Are Required for MacroautophagyCell, 146
C. Jung, Chang-Bong Jun, Seung-Hyun Ro, Young-Mi Kim, N. Otto, Jing Cao, M. Kundu, Do-Hyung Kim (2009)
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.Molecular biology of the cell, 20 7
Yuchen Feng, Steven Backues, M. Baba, Jin-Mi Heo, J. Harper, D. Klionsky (2016)
Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formationAutophagy, 12
A. Oberstein, P. Jeffrey, Yigong Shi (2007)
Crystal Structure of the Bcl-XL-Beclin 1 Peptide ComplexJournal of Biological Chemistry, 282
G. Fimia, Anastassia Stoykova, A. Romagnoli, Luigi Giunta, S. Bartolomeo, R. Nardacci, M. Corazzari, C. Fuoco, A. Ucar, P. Schwartz, P. Gruss, M. Piacentini, K. Chowdhury, F. Cecconi (2007)
Ambra1 regulates autophagy and development of the nervous systemNature, 447
Naotada Ishihara, Maho Hamasaki, S. Yokota, Kuninori Suzuki, Y. Kamada, A. Kihara, T. Yoshimori, T. Noda, Y. Ohsumi (2001)
Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion.Molecular biology of the cell, 12 11
Meiyan Jin, Dingxuan He, Steven Backues, M. Freeberg, Xu Liu, John Kim, D. Klionsky (2014)
Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome FormationCurrent Biology, 24
Qiming Sun, Weiliang Fan, Keling Chen, Xiaojun Ding, She Chen, Q. Zhong (2008)
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinaseProceedings of the National Academy of Sciences, 105
K. Moreau, B. Ravikumar, Maurizio Renna, C. Puri, D. Rubinsztein (2011)
Autophagosome Precursor Maturation Requires Homotypic FusionCell, 146
Liang Ge, M. Zhang, R. Schekman (2014)
Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartmenteLife, 3
Fiona Menzies, Angeleen Fleming, D. Rubinsztein (2015)
Compromised autophagy and neurodegenerative diseasesNature Reviews Neuroscience, 16
Kuninori Suzuki, Y. Kubota, T. Sekito, Y. Ohsumi (2007)
Hierarchy of Atg proteins in pre‐autophagosomal structure organizationGenes to Cells, 12
Jiefei Geng, Usha Nair, Kyoko Yasumura-Yorimitsu, D. Klionsky (2010)
Post-Golgi Sec Proteins Are Required for Autophagy in Saccharomyces cerevisiaeMolecular Biology of the Cell, 21
H. Cheong, Usha Nair, Jiefei Geng, D. Klionsky (2007)
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae.Molecular biology of the cell, 19 2
Pui-Mun wong, Yan Feng, Junru Wang, Rong Shi, Xuejun Jiang (2015)
Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2ANature Communications, 6
Lígia Gomes, I. Dikič (2014)
Autophagy in antimicrobial immunity.Molecular cell, 54 2
R. Stanley, M. Ragusa, J. Hurley (2014)
The beginning of the end: how scaffolds nucleate autophagosome biogenesis.Trends in cell biology, 24 1
Sho Suzuki, Hayashi Yamamoto, Y. Oikawa, Chika Kondo-Kakuta, Y. Kimura, H. Hirano, Y. Ohsumi (2015)
Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formationProceedings of the National Academy of Sciences, 112
C. Lamb, T. Yoshimori, S. Tooze (2013)
The autophagosome: origins unknown, biogenesis complexNature Reviews Molecular Cell Biology, 14
Carla Bento, Maurizio Renna, G. Ghislat, C. Puri, A. Ashkenazi, M. Vicinanza, Fiona Menzies, D. Rubinsztein (2016)
Mammalian Autophagy: How Does It Work?Annual review of biochemistry, 85
G. Drin, J. Casella, R. Gautier, Thomas Boehmer, T. Schwartz, B. Antonny (2007)
A general amphipathic alpha-helical motif for sensing membrane curvature.Nature structural & molecular biology, 14 2
Autophagy is the process of cellular self-eating by a double-membrane organelle, the autophagosome. A range of signaling processes converge on two protein complexes to initiate autophagy: the ULK1 (unc51-like autophagy activating kinase 1) protein kinase complex and the PI3KC3–C1 (class III phosphatidylinositol 3-kinase complex I) lipid kinase complex. Some 90% of the mass of these large protein complexes consists of noncatalytic domains and subunits, and the ULK1 complex has essential noncatalytic activities. Structural studies of these complexes have shed increasing light on the regulation of their catalytic and noncatalytic activities in autophagy initiation. The autophagosome is thought to nucleate from vesicles containing the integral membrane protein Atg9 (autophagy-related 9), COPII (coat protein complex II) vesicles, and possibly other sources. In the wake of reconstitution and super-resolution imaging studies, we are beginning to understand how the ULK1 and PI3KC3–C1 complexes might coordinate the nucleation and fusion of Atg9 and COPII vesicles at the start of autophagosome biogenesis.
Annual Review of Biochemistry – Annual Reviews
Published: Jun 20, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.