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- Publisher
- Annual Reviews
- Copyright
- Copyright © 2017 by Annual Reviews. All rights reserved
- ISSN
- 1936-1327
- eISSN
- 1936-1335
- DOI
- 10.1146/annurev-anchem-061516-045150
- pmid
- 28301751
- Publisher site
- See Article on Publisher Site
Abstract
Electrochemical impedance spectroscopy (EIS) measures the frequency spectrum of an electrochemical interface to resist an alternating current. This method allows label-free and noninvasive studies on interfacial adsorption and molecular interactions and has applications in biosensing and drug screening. Although powerful, traditional EIS lacks spatial resolution or imaging capability, hindering the study of heterogeneous electrochemical processes on electrodes. We have recently developed a plasmonics-based electrochemical impedance technique to image local electrochemical impedance with a submicron spatial resolution and a submillisecond temporal resolution. In this review, we provide a systematic description of the theory, instrumentation, and data analysis of this technique. To illustrate its present and future applications, we further describe several selected samples analyzed with this method, including protein microarrays, two-dimensional materials, and single cells. We conclude by summarizing the technique's unique features and discussing the remaining challenges and new directions of its application.
Journal
Annual Review of Analytical Chemistry – Annual Reviews
Published: Jun 12, 2017