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Jia Sun, E. Yu, Yuting Yang, L. Confer, Steven Sun, K. Wan, N. Lue, M. Lei (2009)
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.Genes & development, 23 24
E. Blackburn, C. Greider, J. Szostak (2006)
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and agingNature Medicine, 12
Catherine O'Connor, K. Collins (2006)
A Novel RNA Binding Domain in Tetrahymena Telomerase p65 Initiates Hierarchical Assembly of Telomerase HoloenzymeMolecular and Cellular Biology, 26
Y. Surovtseva, D. Churikov, K. Boltz, Xiangyu Song, J. Lamb, Ross Warrington, Katherine Leehy, M. Heacock, C. Price, D. Shippen (2009)
Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Molecular cell, 36 2
S. Mahmoudi, S. Henriksson, I. Weibrecht, Stephen Smith, O. Söderberg, S. Strömblad, K. Wiman, M. Farnebo (2010)
WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal BodiesPLoS Biology, 8
Emily Egan, K. Collins (2012)
Biogenesis of telomerase ribonucleoproteins.RNA, 18 10
Emily Egan, K. Collins (2012)
An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNAMolecular and Cellular Biology, 32
Joshua Podlevsky, C. Bley, Rebecca Omana, Xiaodong Qi, Julian Chen (2007)
The Telomerase DatabaseNucleic Acids Research, 36
X. Manival, C. Charron, J. Fourmann, F. Godard, B. Charpentier, C. Branlant (2006)
Crystal structure determination and site-directed mutagenesis of the Pyrococcus abyssi aCBF5–aNOP10 complex reveal crucial roles of the C-terminal domains of both proteins in H/ACA sRNP activityNucleic Acids Research, 34
K. Hong, Heather Upton, E. Miracco, Jiansen Jiang, Z. Zhou, J. Feigon, K. Collins (2013)
Tetrahymena Telomerase Holoenzyme Assembly, Activation, and Inhibition by Domains of the p50 Central HubMolecular and Cellular Biology, 33
Dan Liu, Amin Safari, M. O'Connor, D. Chan, A. Laegeler, J. Qin, Songyang Zhou (2004)
PTOP interacts with POT1 and regulates its localization to telomeresNature Cell Biology, 6
Norie Sugitani, W. Chazin (2015)
Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.Progress in biophysics and molecular biology, 117 2-3
B. Wan, T. Tang, Heather Upton, J. Shuai, Yuan Zhou, Song Li, Juan Chen, J. Brunzelle, Z. Zeng, K. Collins, Jian Wu, M. Lei (2015)
The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complexNature Structural &Molecular Biology, 22
Hua Gao, Rachel Cervantes, Edward Mandell, J. Otero, V. Lundblad (2007)
RPA-like proteins mediate yeast telomere functionNature Structural &Molecular Biology, 14
R. Wu, K. Collins (2014)
Human telomerase specialization for repeat synthesis by unique handling of primer‐template duplexThe EMBO Journal, 33
Liuh-Yow Chen, Sophie Redon, J. Lingner (2012)
The human CST complex is a terminator of telomerase activityNature, 488
Michael Stone, Mariana Mihalusova, Catherine O'Connor, R. Prathapam, K. Collins, X. Zhuang (2007)
Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoproteinNature, 446
David Alves, Haitao Li, R. Codrington, Á. Orte, Xiaojun Ren, D. Klenerman, S. Balasubramanian (2008)
Single-molecule analysis of human telomerase monomer.Nature chemical biology, 4 5
S. Shukla, Jens Schmidt, Katherine Goldfarb, T. Cech, R. Parker (2016)
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defectsNature structural & molecular biology, 23
A. Nelson, D. Shippen (2015)
Evolution of TERT-interacting lncRNAs: expanding the regulatory landscape of telomeraseFrontiers in Genetics, 6
B. Akiyama, J. Parks, Michael Stone (2015)
The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA–DNA hybridsNucleic Acids Research, 43
F. Zhong, L. Batista, Adam Freund, Matthew Pech, A. Venteicher, S. Artandi (2012)
TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome EndsCell, 150
A. Robart, K. Collins (2009)
Investigation of Human Telomerase Holoenzyme Assembly, Activity, and Processivity Using Disease-linked Subunit Variants*The Journal of Biological Chemistry, 285
Darren Casteel, Shunhui Zhuang, Ying Zeng, F. Perrino, G. Boss, M. Goulian, R. Pilz (2009)
A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells*Journal of Biological Chemistry, 284
Scott Cohen, M. Graham, G. Lovrecz, N. Bache, P. Robinson, R. Reddel (2007)
Protein Composition of Catalytically Active Human Telomerase from Immortal CellsScience, 315
C. Price, K. Boltz, M. Chaiken, J. Stewart, M. Beilstein, D. Shippen (2010)
Evolution of CST function in telomere maintenanceCell Cycle, 9
Benjamin Linger, G. Morin, C. Price (2011)
The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in TetrahymenaMolecular Biology of the Cell, 22
A. Venteicher, Eladio Abreu, Z. Meng, Kelly McCann, R. Terns, T. Veenstra, M. Terns, S. Artandi (2009)
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere SynthesisScience, 323
Rachel Niederer, D. Zappulla (2015)
Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPERNA, 21
Daud Cole, Jason Legassie, L. Bonifacio, Vijay Sekaran, F. Ding, N. Dokholyan, M. Jarstfer (2012)
New models of Tetrahymena telomerase RNA from experimentally derived constraints and modeling.Journal of the American Chemical Society, 134 49
Karen Lewis, D. Wuttke (2012)
Telomerase and telomere-associated proteins: structural insights into mechanism and evolution.Structure, 20 1
A. Zaug, E. Podell, T. Cech (2008)
Mutation in TERT separates processivity from anchor-site functionNature structural & molecular biology, 15
E. Yu, Jia Sun, M. Lei, N. Lue (2011)
Analyses of Candida Cdc13 Orthologues Revealed a Novel OB Fold Dimer Arrangement, Dimerization-Assisted DNA Binding, and Substantial Structural Differences between Cdc13 and RPA70Molecular and Cellular Biology, 32
B. Akiyama, Anastassia Gomez, Michael Stone (2013)
A Conserved Motif in Tetrahymena thermophila Telomerase Reverse Transcriptase Is Proximal to the RNA Template and Is Essential for Boundary Definition*The Journal of Biological Chemistry, 288
Jing Huang, Andrew Brown, Jian Wu, Jing Xue, C. Bley, Dustin Rand, Lijie Wu, Rong-guang Zhang, Julian Chen, M. Lei (2014)
Structural basis for protein-RNA recognition in telomeraseNature Structural &Molecular Biology, 21
N. Grandin, C. Damon, M. Charbonneau (2001)
Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13The EMBO Journal, 20
Liuh-Yow Chen, J. Lingner (2013)
CST for the grand finale of telomere replicationNucleus, 4
C. Theimer, B. Jády, N. Chim, Patricia Richard, K. Breece, T. Kiss, J. Feigon (2007)
Structural and functional characterization of human telomerase RNA processing and cajal body localization signals.Molecular cell, 27 6
R. Rashid, B. Liang, D. Baker, Osama Youssef, Yang He, K. Phipps, R. Terns, M. Terns, Hong Li (2006)
Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.Molecular cell, 21 2
Mark Mason, A. Schuller, E. Skordalakes (2011)
Telomerase structure function.Current opinion in structural biology, 21 1
B. Liang, S. Xue, R. Terns, M. Terns, Hong Li (2007)
Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complexNature Structural &Molecular Biology, 14
Andrew Dalby, Ctirad Hofr, T. Cech (2015)
Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Journal of molecular biology, 427 6 Pt B
P. Martínez, M. Blasco (2015)
Replicating through telomeres: a means to an end.Trends in biochemical sciences, 40 9
M. Jaskelioff, F. Muller, J. Paik, Emily Thomas, Shan Jiang, A. Adams, Ergun Sahin, M. Kost-Alimova, A. Protopopov, J. Cadiñanos, J. Horner, E. Maratos-Flier, R. DePinho (2010)
Telomerase reactivation reverses tissue degeneration in aged telomerase deficient miceNature, 469
Jens Schmidt, T. Cech (2015)
Human telomerase: biogenesis, trafficking, recruitment, and activationGenes & Development, 29
T. Hamma, A. Ferré-D’Amaré (2004)
Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution.Structure, 12 5
S. Jacobs, E. Podell, T. Cech (2006)
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptaseNature Structural &Molecular Biology, 13
Verena Pfeiffer, J. Lingner (2013)
Replication of telomeres and the regulation of telomerase.Cold Spring Harbor perspectives in biology, 5 5
Jiunn-Liang Chen, C. Greider (2003)
Template boundary definition in mammalian telomerase.Genes & development, 17 22
R. Wu, Y. Dagdas, S. Yilmaz, A. Yildiz, K. Collins (2015)
Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexeseLife, 4
C. Greider, E. Blackburn (1989)
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisNature, 337
G. Gavory, M. Symmons, Yamuna Ghosh, D. Klenerman, S. Balasubramanian (2006)
Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling.Biochemistry, 45 44
H. Gasparyan, Ling Xu, Ruben Petreaca, Alexandra Rex, Vanessa Small, Neil Bhogal, Jeffrey Julius, Tariq Warsi, J. Bachant, O. Aparicio, C. Nugent (2009)
Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpointProceedings of the National Academy of Sciences, 106
Haiyan Qi, V. Zakian (2000)
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Genes & development, 14 14
Shuang Li, Jingqi Duan, Dandan Li, Shoucai Ma, K. Ye (2011)
Structure of the Shq1–Cbf5–Nop10–Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenitaThe EMBO Journal, 30
Mingyi Xie, A. Mosig, Xiaodong Qi, Yang Li, P. Stadler, Julian Chen (2008)
Structure and Function of the Smallest Vertebrate Telomerase RNA from Teleost Fish*Journal of Biological Chemistry, 283
Joshua Podlevsky, Julian Chen (2016)
Evolutionary perspectives of telomerase RNA structure and functionRNA Biology, 13
Jia Sun, Yuting Yang, K. Wan, Ninghui Mao, Tai-Yuan Yu, Yi-Chien Lin, D. Dezwaan, B. Freeman, Jing-Jer Lin, N. Lue, M. Lei (2011)
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase αCell Research, 21
A. Zaug, E. Podell, J. Nandakumar, T. Cech (2010)
Functional interaction between telomere protein TPP1 and telomerase.Genes & development, 24 6
S. Artandi, R. DePinho (2010)
Telomeres and telomerase in cancer.Carcinogenesis, 31 1
Aishwarya Prakash, G. Borgstahl (2012)
The structure and function of replication protein A in DNA replication.Sub-cellular biochemistry, 62
P. Fogarty, H. Yamaguchi, A. Wiestner, G. Baerlocher, E. Sloand, W. Zeng, E. Read, P. Lansdorp, N. Young (2003)
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNAThe Lancet, 362
Cary Lai, Michael Miller, K. Collins (2002)
Template boundary definition in Tetrahymena telomerase.Genes & development, 16 4
Tsz Chu, D. MacNeil, C. Autexier (2016)
Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases*The Journal of Biological Chemistry, 291
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, M. O'Connor, Songyang Zhou (2007)
TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomeraseNature, 445
Mahavir Singh, Zhonghua Wang, Bon‐Kyung Koo, A. Patel, D. Cascio, K. Collins, J. Feigon (2012)
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.Molecular cell, 47 1
Jing-Jer Lin, V. Zakian (1996)
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.Proceedings of the National Academy of Sciences of the United States of America, 93 24
J. Lingner, T. Hughes, A. Shevchenko, M. Mann, V. Lundblad, T. Cech (1997)
Reverse transcriptase motifs in the catalytic subunit of telomerase.Science, 276 5312
E. Miracco, Jiansen Jiang, D. Cash, J. Feigon (2014)
Progress in structural studies of telomerase.Current opinion in structural biology, 24
C. Bryan, C. Rice, M. Harkisheimer, D. Schultz, E. Skordalakes (2013)
Structure of the Human Telomeric Stn1-Ten1 Capping ComplexPLoS ONE, 8
J. Feigon, H. Chan, Jiansen Jiang (2016)
Integrative structural biology of Tetrahymena telomerase – insights into catalytic mechanism and interaction at telomeresThe FEBS Journal, 283
Jeffrey Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, T. Lange (2004)
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.Genes & development, 18 14
T. Lange (2005)
Shelterin: the protein complex that shapes and safeguards human telomeresGenes & Development, 19
S. Froelich-Ammon, B. Dickinson, J. Bevilacqua, S. Schultz, T. Cech (1998)
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.Genes & development, 12 10
Shuang Li, Jingqi Duan, Dandan Li, Bing Yang, Meng-Qiu Dong, K. Ye (2011)
Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase.Genes & development, 25 22
Emily Egan, K. Collins (2010)
Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In VivoMolecular and Cellular Biology, 30
R. Richards, Haihong Wu, L. Trantírek, Catherine O'Connor, K. Collins, J. Feigon (2006)
Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function.RNA, 12 8
Linnea Jansson, B. Akiyama, Alexandra Ooms, Cheng Lu, S. Rubin, Michael Stone (2015)
Structural Basis of Template Boundary Definition in Tetrahymena TelomeraseNature structural & molecular biology, 22
Yasuyuki Miyake, Mirai Nakamura, A. Nabetani, Shintaro Shimamura, Miki Tamura, S. Yonehara, Motoki Saito, F. Ishikawa (2009)
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.Molecular cell, 36 2
A. Malyavko, Yuliya Parfenova, Maria Zvereva, O. Dontsova (2014)
Telomere length regulation in budding yeastsFEBS Letters, 588
Y. Tzfati, Tracy Fulton, J. Roy, Elizabeth Blackburn (2000)
Template boundary in a yeast telomerase specified by RNA structure.Science, 288 5467
Jens Schmidt, Andrew Dalby, T. Cech (2014)
Identification of human TERT elements necessary for telomerase recruitment to telomereseLife, 3
Rachel Mitton-Fry, E. Anderson, T. Hughes, V. Lundblad, D. Wuttke (2002)
Conserved Structure for Single-Stranded Telomeric DNA RecognitionScience, 296
K. Tycowski, M. Shu, A. Kukoyi, J. Steitz (2009)
A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles.Molecular cell, 34 1
Roderick O’Sullivan, J. Karlseder (2010)
Telomeres: protecting chromosomes against genome instabilityNature Reviews Molecular Cell Biology, 11
Nak-Kyoon Kim, Qi Zhang, Jing Zhou, C. Theimer, R. Peterson, J. Feigon (2008)
Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA.Journal of molecular biology, 384 5
Feng Wang, E. Podell, A. Zaug, Yuting Yang, Paul Baciu, T. Cech, M. Lei (2007)
The POT1–TPP1 telomere complex is a telomerase processivity factorNature, 445
Rachel Mitton-Fry, E. Anderson, D. Theobald, L. Glustrom, D. Wuttke (2004)
Structural basis for telomeric single-stranded DNA recognition by yeast Cdc13.Journal of molecular biology, 338 2
Andrew Gillis, A. Schuller, E. Skordalakes (2008)
Structure of the Tribolium castaneum telomerase catalytic subunit TERTNature, 455
M. Mitchell, Andrew Gillis, Mizuko Futahashi, H. Fujiwara, E. Skordalakes (2010)
Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNANature Structural &Molecular Biology, 17
Bosun Min, K. Collins (2009)
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance.Molecular cell, 36 4
M. Armanios, E. Blackburn (2012)
The telomere syndromesNature Reviews Genetics, 13
N. Grandin, S. Reed, M. Charbonneau (1997)
Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Genes & development, 11 4
C. Theimer, J. Feigon (2006)
Structure and function of telomerase RNA.Current opinion in structural biology, 16 3
E. Bochkareva, S. Korolev, S. Lees-Miller, A. Bochkarev (2002)
Structure of the RPA trimerization core and its role in the multistep DNA‐binding mechanism of RPAThe EMBO Journal, 21
A. Berman, B. Akiyama, Michael Stone, T. Cech (2011)
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesisNature structural & molecular biology, 18
Heather Upton, H. Chan, J. Feigon, K. Collins (2016)
Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes*The Journal of Biological Chemistry, 292
Benjamin Linger, C. Price (2009)
Conservation of telomere protein complexes: shuffling through evolutionCritical Reviews in Biochemistry and Molecular Biology, 44
J. Nandakumar, T. Cech (2013)
Finding the end: recruitment of telomerase to telomeresNature Reviews Molecular Cell Biology, 14
K. Collins (2006)
The biogenesis and regulation of telomerase holoenzymesNature Reviews Molecular Cell Biology, 7
Katherine Leehy, Jung Lee, Xiangyu Song, Kyle Renfrew, D. Shippen (2013)
MERISTEM DISORGANIZATION1 Encodes TEN1, an Essential Telomere Protein That Modulates Telomerase Processivity in Arabidopsis[C][W]Plant Cell, 25
Bon‐Kyung Koo, Chin-Ju Park, C. Fernandez, N. Chim, Yi Ding, G. Chanfreau, J. Feigon (2011)
Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.Journal of molecular biology, 411 5
D. Churikov, Y. Corda, P. Luciano, V. Géli (2013)
Cdc13 at a crossroads of telomerase actionFrontiers in Oncology, 3
C. Rice, E. Skordalakes (2016)
Structure and function of the telomeric CST complexComputational and Structural Biotechnology Journal, 14
Jacob Vogan, Xiaozhu Zhang, Daniel Youmans, Samuel Regalado, Joshua Johnson, D. Hockemeyer, K. Collins (2016)
Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodieseLife, 5
Jingqi Duan, Ling Li, Jing Lu, Wei Wang, K. Ye (2009)
Structural mechanism of substrate RNA recruitment in H/ACA RNA-guided pseudouridine synthase.Molecular cell, 34 4
Nak-Kyoon Kim, Qi Zhang, J. Feigon (2013)
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase functionNucleic Acids Research, 42
M. Hengesbach, Nak-Kyoon Kim, J. Feigon, Michael Stone (2012)
Single-molecule FRET reveals the folding dynamics of the human telomerase RNA pseudoknot domain.Angewandte Chemie, 51 24
Tsz Chu, Y. D’Souza, C. Autexier (2015)
The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent MannerMolecular and Cellular Biology, 36
H. Fujii, L. Shao, I. Colmegna, J. Goronzy, C. Weyand (2009)
Telomerase insufficiency in rheumatoid arthritisProceedings of the National Academy of Sciences, 106
S. Rouda, E. Skordalakes (2007)
Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding.Structure, 15 11
M. Lei, E. Podell, T. Cech (2004)
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protectionNature Structural &Molecular Biology, 11
M. Harkisheimer, Mark Mason, E. Shuvaeva, E. Skordalakes (2013)
A motif in the vertebrate telomerase N-terminal linker of TERT contributes to RNA binding and telomerase activity and processivity.Structure, 21 10
G. Cristofari, J. Lingner (2006)
Telomere length homeostasis requires that telomerase levels are limitingThe EMBO Journal, 25
J. Stewart, Feng Wang, M. Chaiken, Christopher Kasbek, P. Chastain, W. Wright, C. Price (2012)
Human CST promotes telomere duplex replication and general replication restart after fork stallingThe EMBO Journal, 31
C. Autexier, N. Lue (2006)
The structure and function of telomerase reverse transcriptase.Annual review of biochemistry, 75
Y. Tzfati, Z. Knight, J. Roy, E. Blackburn (2003)
A novel pseudoknot element is essential for the action of a yeast telomerase.Genes & development, 17 14
Andrew Brown, Joshua Podlevsky, Xiaodong Qi, Yinnan Chen, Mingyi Xie, Julian Chen (2014)
A self-regulating template in human telomeraseProceedings of the National Academy of Sciences, 111
J. Nandakumar, C. Bell, Ina Weidenfeld, A. Zaug, L. Leinwand, T. Cech (2012)
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivityNature, 492
D. Hockemeyer, K. Collins (2015)
Control of telomerase action at human telomeresNature Structural &Molecular Biology, 22
A. Sexton, Samuel Regalado, Christine Lai, G. Cost, C. O'Neil, F. Urnov, P. Gregory, R. Jaenisch, K. Collins, D. Hockemeyer (2014)
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulationGenes & Development, 28
H. Wyatt, S. West, T. Beattie (2010)
InTERTpreting telomerase structure and functionNucleic Acids Research, 38
M. Lei, E. Podell, P. Baumann, T. Cech (2003)
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNANature, 426
C. Wenz, B. Enenkel, M. Amacker, Colleen Kelleher, K. Damm, J. Lingner (2001)
Human telomerase contains two cooperating telomerase RNA moleculesThe EMBO Journal, 20
Yaqiang Wang, J. Yesselman, Qi Zhang, Mijeong Kang, J. Feigon (2016)
Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to humanProceedings of the National Academy of Sciences, 113
Bruno Jesus, M. Blasco (2013)
Telomerase at the intersection of cancer and aging.Trends in genetics : TIG, 29 9
C. Nugent, T. Hughes, N. Lue, V. Lundblad (1996)
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere MaintenanceScience, 274
Yi-Tao Yu, T. Meier (2014)
RNA-guided isomerization of uridine to pseudouridine—pseudouridylationRNA Biology, 11
G. Schnapp, Hans-Peter Rodi, W. Rettig, A. Schnapp, K. Damm (1998)
One-step affinity purification protocol for human telomeraseNucleic acids research, 26 13
C. Greider, E. Blackburn (1985)
Identification of a specific telomere terminal transferase activity in tetrahymena extractsCell, 43
A. Marrone, A. Walne, I. Dokal (2005)
Dyskeratosis congenita: telomerase, telomeres and anticipation.Current opinion in genetics & development, 15 3
J. Stewart, M. Chaiken, Feng Wang, C. Price (2012)
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation.Mutation research, 730 1-2
D. Cash, O. Cohen-Zontag, Nak-Kyoon Kim, Kinneret Shefer, Yogev Brown, N. Ulyanov, Y. Tzfati, J. Feigon (2013)
Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivoProceedings of the National Academy of Sciences, 110
D. Townsley, B. Dumitriu, N. Young (2014)
Bone marrow failure and the telomeropathies.Blood, 124 18
E. Blackburn, K. Collins (2011)
Telomerase: an RNP enzyme synthesizes DNA.Cold Spring Harbor perspectives in biology, 3 5
N. Lue, You-Chin Lin, I. Mian (2003)
A Conserved Telomerase Motif within the Catalytic Domain of Telomerase Reverse Transcriptase Is Specifically Required for Repeat Addition ProcessivityMolecular and Cellular Biology, 23
N. Lue, Jamie Chan, W. Wright, J. Hurwitz (2014)
THE CDC13-STN1-TEN1 COMPLEX STIMULATES POL α ACTIVITY BY PROMOTING RNA PRIMING AND PRIMASE-TO-POLYMERASE SWITCHNature communications, 5
M. Kupiec (2014)
Biology of telomeres: lessons from budding yeast.FEMS microbiology reviews, 38 2
Liuh-Yow Chen, Jana Majerská, J. Lingner (2013)
Molecular basis of telomere syndrome caused by CTC1 mutationsGenes & Development, 27
Jiunn-Liang Chen, M. Blasco, C. Greider (2000)
Secondary Structure of Vertebrate Telomerase RNACell, 100
C. Theimer, C. Blois, J. Feigon (2005)
Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.Molecular cell, 17 5
T. Bryan, Karen Goodrich, T. Cech (2003)
Tetrahymena telomerase is active as a monomer.Molecular biology of the cell, 14 12
Yu Chen, Jessica Fender, Jason Legassie, M. Jarstfer, T. Bryan, G. Varani (2006)
Structure of stem‐loop IV of Tetrahymena telomerase RNAThe EMBO Journal, 25
J. Parks, Michael Stone (2014)
Coordinated DNA dynamics during the human telomerase catalytic cycleNature communications, 5
J. Watson, K. Ríha (2010)
Comparative biology of telomeres: Where plants standFebs Letters, 584
S. Savage, A. Bertuch (2010)
The genetics and clinical manifestations of telomere biology disordersGenetics in Medicine, 12
Mark Mason, Mark Mason, Jennifer Wanat, S. Harper, D. Schultz, D. Speicher, F. Johnson, E. Skordalakes, E. Skordalakes (2013)
Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance.Structure, 21 1
K. Lin, V. Zakian (2015)
21st Century Genetics: Mass Spectrometry of Yeast Telomerase.Cold Spring Harbor symposia on quantitative biology, 80
Naduparambil Jacob, R. Skopp, C. Price (2001)
G‐overhang dynamics at Tetrahymena telomeresThe EMBO Journal, 20
Heather Upton, K. Hong, K. Collins (2014)
Direct Single-Stranded DNA Binding by Teb1 Mediates the Recruitment of Tetrahymena thermophila Telomerase to TelomeresMolecular and Cellular Biology, 34
C. Bley, Xiaodong Qi, Dustin Rand, C. Borges, R. Nelson, Julian Chen (2011)
RNA–protein binding interface in the telomerase ribonucleoproteinProceedings of the National Academy of Sciences, 108
Qi Zhang, Nak-Kyoon Kim, J. Feigon (2011)
Architecture of human telomerase RNAProceedings of the National Academy of Sciences, 108
Timothy Errington, Dragony Fu, J. Wong, K. Collins (2008)
Disease-Associated Human Telomerase RNA Variants Show Loss of Function for Telomere Synthesis without Dominant-Negative InterferenceMolecular and Cellular Biology, 28
Jiansen Jiang, H. Chan, D. Cash, E. Miracco, R. Loo, Heather Upton, D. Cascio, Reid Johnson, K. Collins, J. Loo, Z. Zhou, J. Feigon (2015)
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactionsScience, 350
M. Rajavel, M. Mullins, Derek Taylor (2014)
Multiple facets of TPP1 in telomere maintenance.Biochimica et biophysica acta, 1844 9
Schraga Schwartz, D. Bernstein, Maxwell Mumbach, M. Jovanović, Rebecca Herbst, Brian León-Ricardo, J. Engreitz, M. Guttman, R. Satija, E. Lander, G. Fink, A. Regev (2014)
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNACell, 159
R. Wellinger, V. Zakian (2012)
Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to EndGenetics, 191
T. Kiss, Eléonore Fayet-Lebaron, B. Jády (2010)
Box H/ACA small ribonucleoproteins.Molecular cell, 37 5
Nak-Kyoon Kim, C. Theimer, James Mitchell, K. Collins, J. Feigon (2010)
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNANucleic Acids Research, 38
Vidjaya Premkumar, S. Cranert, Benjamin Linger, G. Morin, Sasha Minium, C. Price (2013)
The 3′ Overhangs at Tetrahymena thermophila Telomeres Are Packaged by Four Proteins, Pot1a, Tpt1, Pat1, and Pat2Eukaryotic Cell, 13
A. Sexton, Daniel Youmans, K. Collins (2012)
Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme*The Journal of Biological Chemistry, 287
Cary Lai, James Mitchell, Kathleen Collins (2001)
RNA Binding Domain of Telomerase Reverse TranscriptaseMolecular and Cellular Biology, 21
F. Qiao, Karen Goodrich, T. Cech (2010)
Engineering cis-telomerase RNAs that add telomeric repeats to themselvesProceedings of the National Academy of Sciences, 107
Colleen Kelleher, M.Teresa Teixeira, K. Förstemann, J. Lingner (2002)
Telomerase: biochemical considerations for enzyme and substrate.Trends in biochemical sciences, 27 11
D. Cash, J. Feigon (2016)
Structure and folding of the Tetrahymena telomerase RNA pseudoknotNucleic Acids Research, 45
Peili Gu, Sandy Chang (2013)
Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plusAging Cell, 12
M. Mitchell, Jasmine Smith, Mark Mason, S. Harper, D. Speicher, F. Johnson, E. Skordalakes (2010)
Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length RegulationMolecular and Cellular Biology, 30
M. Horvath, V. Schweiker, J. Bevilacqua, J. Ruggles, S. Schultz (1998)
Crystal Structure of the Oxytricha nova Telomere End Binding Protein Complexed with Single Strand DNACell, 95
J. Shay (2016)
Role of Telomeres and Telomerase in Aging and Cancer.Cancer discovery, 6 6
Feng Wang, J. Stewart, C. Price (2014)
Human CST abundance determines recovery from diverse forms of DNA damage and replication stressCell Cycle, 13
Ling Li, K. Ye (2006)
Crystal structure of an H/ACA box ribonucleoprotein particleNature, 443
T. Hamma, A. Ferré-D’Amaré (2009)
The Box H/ACA Ribonucleoprotein Complex: Interplay of RNA and Protein Structures in Post-transcriptional RNA Modification*The Journal of Biological Chemistry, 285
G. Sarek, Paulina Marzec, Pol Margalef, S. Boulton (2015)
Molecular basis of telomere dysfunction in human genetic diseasesNature Structural &Molecular Biology, 22
Kinneret Shefer, Yogev Brown, Valentin Gorkovoy, Tamar Nussbaum, N. Ulyanov, Y. Tzfati (2007)
A Triple Helix within a Pseudoknot Is a Conserved and Essential Element of Telomerase RNAMolecular and Cellular Biology, 27
R. Richards, C. Theimer, L. Finger, J. Feigon (2006)
Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary elementNucleic Acids Research, 34
N. Lloyd, T. Dickey, R. Hom, D. Wuttke (2016)
Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.Biochemistry, 55 38
Emmanuel Bajon, N. Laterreur, R. Wellinger (2015)
A Single Templating RNA in Yeast Telomerase.Cell reports, 12 3
Jiansen Jiang, E. Miracco, K. Hong, B. Eckert, H. Chan, D. Cash, Bosun Min, Z. Zhou, K. Collins, J. Feigon (2013)
The architecture of Tetrahymena telomerase holoenzymeNature, 496
Catherine O'Connor, Cary Lai, K. Collins (2005)
Two Purified Domains of Telomerase Reverse Transcriptase Reconstitute Sequence-specific Interactions with RNA*Journal of Biological Chemistry, 280
Z. Zeng, Bosun Min, Jing Huang, K. Hong, Yuting Yang, K. Collins, M. Lei (2011)
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNAProceedings of the National Academy of Sciences, 108
Patricia Richard, X. Darzacq, E. Bertrand, B. Jády, C. Verheggen, T. Kiss (2003)
A common sequence motif determines the Cajal body‐specific localization of box H/ACA scaRNAsThe EMBO Journal, 22
B. Eckert, K. Collins (2012)
Roles of Telomerase Reverse Transcriptase N-terminal Domain in Assembly and Activity of Tetrahymena Telomerase Holoenzyme*The Journal of Biological Chemistry, 287
A. Gelinas, Margherita Paschini, F. Reyes, A. Héroux, R. Batey, V. Lundblad, D. Wuttke (2009)
Telomere capping proteins are structurally related to RPA with an additional telomere-specific domainProceedings of the National Academy of Sciences, 106
Naduparambil Jacob, Rachel Lescasse, Benjamin Linger, C. Price (2006)
Tetrahymena POT1a Regulates Telomere Length and Prevents Activation of a Cell CycleCheckpointMolecular and Cellular Biology, 27
A. Sauerwald, S. Sandin, G. Cristofari, S. Scheres, J. Lingner, D. Rhodes (2013)
Structure of Active, Dimeric Human TelomeraseNature structural & molecular biology, 20
F. Qiao, T. Cech (2008)
Triple-helix structure in telomerase RNA contributes to catalysisNature structural & molecular biology, 15
C. Greider, E. Blackburn (1987)
The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificityCell, 51
Telomerase is an RNA–protein complex that extends the 3′ ends of linear chromosomes, using a unique telomerase reverse transcriptase (TERT) and template in the telomerase RNA (TR), thereby helping to maintain genome integrity. TR assembles with TERT and species-specific proteins, and telomerase function in vivo requires interaction with telomere-associated proteins. Over the past two decades, structures of domains of TR and TERT as well as other telomerase- and telomere-interacting proteins have provided insights into telomerase function. A recently reported 9-Å cryo–electron microscopy map of the Tetrahymena telomerase holoenzyme has provided a framework for understanding how TR, TERT, and other proteins from ciliate as well as vertebrate telomerase fit and function together as well as unexpected insight into telomerase interaction at telomeres. Here we review progress in understanding the structural basis of human and Tetrahymena telomerase activity, assembly, and interactions.
Annual Review of Biophysics – Annual Reviews
Published: May 22, 2017
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