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L. Piacentini, L. Fanti, V. Specchia, M. Bozzetti, M. Berloco, G. Palumbo, S. Pimpinelli (2014)
Transposons, environmental changes, and heritable induced phenotypic variabilityChromosoma, 123
J. Cooke, M. Nowak, M. Boerlijst, J. Maynard-Smith (1997)
Evolutionary origins and maintenance of redundant gene expression during metazoan development.Trends in genetics : TIG, 13 9
R. Ellis
Macromolecular crowding : obvious but underappreciated
Michael Gilchrist, H. Nijhout (2001)
Nonlinear developmental processes as sources of dominance.Genetics, 159 1
K. Wolfe, D. Shields (1997)
Molecular evidence for an ancient duplication of the entire yeast genomeNature, 387
Kathy Scienski, Justin Fay, Gavin Conant (2015)
Patterns of Gene Conversion in Duplicated Yeast Histones Suggest Strong Selection on a Coadapted Macromolecular ComplexGenome Biology and Evolution, 7
S. Shen-Orr, R. Milo, S. Mangan, U. Alon (2002)
Network motifs in the transcriptional regulation network of Escherichia coliNature Genetics, 31
H. Muller (1925)
Why Polyploidy is Rarer in Animals Than in PlantsThe American Naturalist, 59
A. Deutschbauer, Daniel Jaramillo, M. Proctor, J. Kumm, Maureen Hillenmeyer, Ronald Davis, C. Nislow, G. Giaever (2005)
Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in YeastGenetics, 169
Sina Ghaemmaghami, W. Huh, Kiowa Bower, R. Howson, Archana Belle, Noah Dephoure, E. O’Shea, J. Weissman (2003)
Global analysis of protein expression in yeastNature, 425
M. Ko (1991)
A stochastic model for gene induction.Journal of theoretical biology, 153 2
L. Hakes, J. Pinney, S. Lovell, S. Oliver, D. Robertson (2007)
All duplicates are not equal: the difference between small-scale and genome duplicationGenome Biology, 8
Xinxian Deng, Joseph Hiatt, D. Nguyen, Sevinç Ercan, David Sturgill, L. Hillier, F. Schlesinger, Carrie Davis, V. Reinke, T. Gingeras, J. Shendure, R. Waterston, B. Oliver, J. Lieb, C. Disteche (2011)
Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogasterNature Genetics, 43
Y. Kuwada
Maiosis in the Pollen Mother Cells of Zea Mays L. (With Plate V.), 25
Christopher Rao, D. Wolf, A. Arkin (2002)
Control, exploitation and tolerance of intracellular noiseNature, 420
A. Rovelet-Lecrux, D. Hannequin, G. Raux, N. Meur, A. Laquérriere, A. Vital, C. Dumanchin, Sebastien Feuillette, A. Brice, M. Vercelletto, F. Dubas, T. Frebourg, D. Campion (2006)
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathyNature Genetics, 38
R. Prill, P. Iglesias, A. Levchenko (2005)
Dynamic Properties of Network Motifs Contribute to Biological Network OrganizationPLoS Biology, 3
G. Conant (2014)
Comparative genomics as a time machine: how relative gene dosage and metabolic requirements shaped the time-dependent resolution of yeast polyploidy.Molecular biology and evolution, 31 12
J. Birchler (2010)
Reflections on studies of gene expression in aneuploids.The Biochemical journal, 426 2
J. Newman, Sina Ghaemmaghami, Jan Ihmels, David Breslow, M. Noble, J. Derisi, J. Weissman (2006)
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noiseNature, 441
H. Muller (1935)
The origination of chromatin deficiencies as minute deletions subject to insertion elsewhereGenetica, 17
T. Vavouri, J. Semple, Rosa Garcı́a-Verdugo, Ben Lehner (2009)
Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage SensitivityCell, 138
Nitin Phadnis, J. Fry (2005)
Widespread Correlations Between Dominance and Homozygous Effects of Mutations: Implications for Theories of DominanceGenetics, 171
Joshua Payne, A. Wagner (2014)
The Robustness and Evolvability of Transcription Factor Binding SitesScience, 343
C. Seoighe, K. Wolfe (1999)
Yeast genome evolution in the post-genome era.Current opinion in microbiology, 2 5
Noah Dephoure, Sunyoung Hwang, Ciara O’sullivan, S. Dodgson, S. Gygi, A. Amon, Eduardo Torres (2014)
Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeasteLife, 3
M. Bucciantini, E. Giannoni, F. Chiti, F. Baroni, L. Formigli, J. Zurdo, N. Taddei, G. Ramponi, C. Dobson, M. Stefani (2002)
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseasesNature, 416
J. Birchler, R. Veitia (2012)
Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplinesProceedings of the National Academy of Sciences, 109
G. Conant, J. Birchler, J. Pires (2014)
Dosage, duplication, and diploidization: clarifying the interplay of multiple models for duplicate gene evolution over time.Current opinion in plant biology, 19
R. Veitia, S. Bottani, J. Birchler (2013)
Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation.Trends in genetics : TIG, 29 7
Åsa Pérez-Bercoff, A. McLysaght, G. Conant (2011)
Patterns of indirect protein interactions suggest a spatial organization to metabolism.Molecular bioSystems, 7 11
J. Korbel, T. Tirosh-Wagner, A. Urban, Xiao-Ning Chen, Maya Kasowski, Li Dai, Fabian Grubert, Chandra Erdman, Michael Gao, K. Lange, E. Sobel, G. Barlow, A. Aylsworth, N. Carpenter, R. Clark, M. Cohen, E. Doran, T. Falik-Zaccai, S. Lewin, I. Lott, B. Mcgillivray, J. Moeschler, M. Pettenati, S. Pueschel, K. Rao, L. Shaffer, M. Shohat, Alexander Riper, D. Warburton, S. Weissman, M. Gerstein, M. Snyder, J. Korenberg (2009)
The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomiesProceedings of the National Academy of Sciences, 106
J. Spudich, D. Koshland (1976)
Non-genetic individuality: chance in the single cellNature, 262
J. Haldane (1930)
A Note on Fisher's Theory of the Origin of Dominance, and on a Correlation between Dominance and LinkageThe American Naturalist, 64
Zhenglong Gu, L. Steinmetz, X. Gu, C. Scharfe, Ronald Davis, Wen-Hsiung Li (2003)
Role of duplicate genes in genetic robustness against null mutationsNature, 421
D. Drummond, J. Bloom, C. Adami, C. Adami, C. Wilke, C. Wilke, F. Arnold (2005)
Why highly expressed proteins evolve slowly.Proceedings of the National Academy of Sciences of the United States of America, 102 40
George Dassow, E. Meir, E. Munro, G. Odell (2000)
The segment polarity network is a robust developmental moduleNature, 406
B. Charlesworth (1979)
Evidence against Fisher's theory of dominanceNature, 278
R. Clausen, T. Goodspeed (1925)
Interspecific Hybridization in Nicotiana. II. a Tetraploid GLUTINOSA-TABACUM Hybrid, an Experimental Verification of Winge's Hypothesis.Genetics, 10 3
S. Talia, J. Skotheim, J. Bean, E. Siggia, F. Cross (2007)
The effects of molecular noise and size control on variability in the budding yeast cell cycleNature, 448
M. Campanella, Haiyan Chu, P. Low, Joseph Hoffman (2005)
Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane.Proceedings of the National Academy of Sciences of the United States of America, 102 7
H. Orr (1991)
A test of Fisher's theory of dominance.Proceedings of the National Academy of Sciences of the United States of America, 88 24
O. Berg (1978)
A model for the statistical fluctuations of protein numbers in a microbial population.Journal of theoretical biology, 71 4
Jayson Gutiérrez, Steven Maere (2014)
Modeling the evolution of molecular systems from a mechanistic perspective.Trends in plant science, 19 5
J. Aury, O. Jaillon, L. Duret, Benjamin Noel, Claire Jubin, Betina Porcel, Béatrice Segurens, V. Daubin, Véronique Anthouard, N. Aiach, O. Arnaiz, Alain Billaut, J. Beisson, I. Blanc, K. Bouhouche, F. Camara, S. Duharcourt, R. Guigó, Delphine Gogendeau, M. Katinka, A. Keller, R. Kissmehl, C. Klotz, F. Koll, A. Mouël, Gersende Lepère, S. Malinsky, M. Nowacki, J. Nowak, H. Plattner, J. Poulain, F. Ruiz, Vincent Serrano, M. Zagulski, P. Dessen, M. Bétermier, J. Weissenbach, C. Scarpelli, V. Schächter, L. Sperling, E. Meyer, Jean Cohen, P. Wincker (2006)
Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraureliaNature, 444
J. Birchler, N. Riddle, D. Auger, R. Veitia (2005)
Dosage balance in gene regulation: biological implications.Trends in genetics : TIG, 21 4
M. Freeling (2009)
Bias in plant gene content following different sorts of duplication: tandem, whole-genome, segmental, or by transposition.Annual review of plant biology, 60
Lin Sun, Adam Johnson, Jilong Li, A. Lambdin, Jianlin Cheng, J. Birchler (2013)
Differential effect of aneuploidy on the X chromosome and genes with sex-biased expression in DrosophilaProceedings of the National Academy of Sciences, 110
J. Ovádi, F. Orosz, S. Hollán (2004)
Functional aspects of cellular microcompartmentation in the development of neurodegeneration: Mutation induced aberrant protein-protein associationsMolecular and Cellular Biochemistry, 256-257
R. Milo, S. Shen-Orr, S. Itzkovitz, N. Kashtan, D. Chklovskii, U. Alon (2002)
Network motifs: simple building blocks of complex networks.Science, 298 5594
L. Huminiecki, C. Heldin (2010)
2R and remodeling of vertebrate signal transduction engineBMC Biology, 8
J. Taylor, J. Raes (2004)
Duplication and divergence: the evolution of new genes and old ideas.Annual review of genetics, 38
S. Mangan, U. Alon (2003)
Structure and function of the feed-forward loop network motifProceedings of the National Academy of Sciences of the United States of America, 100
R. Fisher (1928)
Two Further Notes on the Origin of DominanceThe American Naturalist, 62
Jin Zhu, Norman Pavelka, W. Bradford, Giulia Rancati, Rong Li (2012)
Karyotypic Determinants of Chromosome Instability in Aneuploid Budding YeastPLoS Genetics, 8
Attila Becskei, L. Serrano (2000)
Engineering stability in gene networks by autoregulationNature, 405
J. Ferrell, E. Machleder (1998)
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.Science, 280 5365
R. Price, A. Uhlemann, A. Brockman, R. McGready, E. Ashley, L. Phaipun, Rina Patel, K. Laing, S. Looareesuwan, N. White, F. Nosten, S. Krishna (2004)
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberThe Lancet, 364
S. Wright (1934)
Physiological and Evolutionary Theories of DominanceThe American Naturalist, 68
Q. Shi, Renée Martin (2000)
Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factorsCytogenetic and Genome Research, 90
R. Mark, Z. Pang, J. Geddes, K. Uchida, M. Mattson (1997)
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid PeroxidationThe Journal of Neuroscience, 17
P. Durek, Dirk Walther (2008)
The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principlesBMC Systems Biology, 2
L. Blank, F. Lehmbeck, U. Sauer (2005)
Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts.FEMS yeast research, 5 6-7
B. Thomas, Brent Pedersen, M. Freeling (2006)
Following tetraploidy in an Arabidopsis ancestor, genes were removed preferentially from one homeolog leaving clusters enriched in dose-sensitive genes.Genome research, 16 7
C. Waddington (1942)
Canalization of Development and the Inheritance of Acquired CharactersNature, 150
Norman Pavelka, Giulia Rancati, Jin Zhu, W. Bradford, Anita Saraf, L. Florens, Brian Sanderson, Gaye Hattem, Rong Li (2010)
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeastNature, 468
DR. Fisher (1928)
The Possible Modification of the Response of the Wild Type to Recurrent MutationsThe American Naturalist, 62
Zhi Wang, Jianzhi Zhang (2011)
Impact of gene expression noise on organismal fitness and the efficacy of natural selectionProceedings of the National Academy of Sciences, 108
H. Kacser, J. Burns (1981)
The molecular basis of dominance.Genetics, 97 3-4
D. Lindsley, L. Sandler, B. Baker, A. Carpenter, R. Denell, J. Hall, P. Jacobs, G. Miklos, B. Davis, R. Gethmann, R. Hardy, A. Hessler, Steven Miller, Hiroshi Nozawa, D. Parry, M. Gould-Somero (1972)
Segmental aneuploidy and the genetic gross structure of the Drosophila genome.Genetics, 71 1
P. Swain, M. Elowitz, E. Siggia (2002)
Intrinsic and extrinsic contributions to stochasticity in gene expressionProceedings of the National Academy of Sciences of the United States of America, 99
J. Taylor, J. Hardy, K. Fischbeck (2002)
Toxic Proteins in Neurodegenerative DiseaseScience, 296
Balázs Papp, Csaba Pál, L. Hurst (2003)
Dosage sensitivity and the evolution of gene families in yeastNature, 424
S. Hoops, S. Sahle, R. Gauges, Christine Lee, Jü Pahle, N. Simus, M. Singhal, Liang Xu, P. Mendes, U. Kummer
Bioinformatics Original Paper Copasi—a Complex Pathway Simulator
S. Wright (1929)
Fisher's Theory of DominanceThe American Naturalist, 63
Matthew Hahn
Distinguishing among Evolutionary Models for the Maintenance of Gene Duplicates Molecular Mechanisms of Gene Duplication Unequal Crossing-over Outcomes and Models of Gene Duplication Subfunctionalization (''the Differential Regulation of Former Alleles and Their Transformation to Isozyme Genes'' [oh
L. Comai (2005)
The advantages and disadvantages of being polyploidNature Reviews Genetics, 6
Tong Lee, Nicola Rinaldi, F. Robert, D. Odom, Z. Bar-Joseph, G. Gerber, N. Hannett, Christopher Harbison, C. Thompson, I. Simon, J. Zeitlinger, E. Jennings, H. Murray, D. Gordon, Bing Ren, John Wyrick, J. Tagne, T. Volkert, E. Fraenkel, D. Gifford, R. Young (2002)
Supporting online material for : Transcriptional Regulatory Networks in Saccharomyces cerevisiae
A. Bar‐Even, J. Paulsson, N. Maheshri, M. Carmi, E. O’Shea, Y. Pilpel, N. Barkai (2006)
Noise in protein expression scales with natural protein abundanceNature Genetics, 38
J. Coate, J. Doyle (2015)
Variation in transcriptome size: are we getting the message?Chromosoma, 124
Steven Marygold, J. Roote, G. Reuter, A. Lambertsson, M. Ashburner, G. Millburn, P. Harrison, Zhan Yu, N. Kenmochi, T. Kaufman, S. Leevers, K. Cook (2007)
The ribosomal protein genes and Minute loci of Drosophila melanogasterGenome Biology, 8
Michael Springer, J. Weissman, M. Kirschner (2010)
A general lack of compensation for gene dosage in yeastMolecular Systems Biology, 6
N. Batada, L. Hurst (2007)
Evolution of chromosome organization driven by selection for reduced gene expression noiseNature Genetics, 39
A. Raj, C. Peskin, D. Tranchina, D. Vargas, Sanjay Tyagi (2006)
Mechanistic model of bursts in mRNA synthesis
A. Wagner (2005)
Distributed robustness versus redundancy as causes of mutational robustness.BioEssays : news and reviews in molecular, cellular and developmental biology, 27 2
G. Conant, A. Wagner (2004)
Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegansProceedings of the Royal Society of London. Series B: Biological Sciences, 271
Professor Fisher, L. Homozygotes (1935)
The Sheltering of LethalsThe American Naturalist, 69
A. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T. Peuralinna, A. Dutra, R. Nussbaum, S. Lincoln, A. Crawley, M. Hanson, D. Maraganore, C. Adler, Michael Cookson, M. Muenter, M. Baptista, D. Miller, J. Blancato, J. Hardy, K. Gwinn‐Hardy (2003)
α-Synuclein Locus Triplication Causes Parkinson's DiseaseScience, 302
C. Brown, Kristy Todd, R. Rosenzweig (1998)
Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited environment.Molecular biology and evolution, 15 8
Anna Selmecki, A. Forche, J. Berman (2006)
Aneuploidy and Isochromosome Formation in Drug-Resistant Candida albicansScience, 313
M. Savageau (1974)
Comparison of classical and autogenous systems of regulation in inducible operonsNature, 252
K. Klemm, S. Bornholdt (2004)
Topology of biological networks and reliability of information processingProceedings of the National Academy of Sciences of the United States of America, 102 51
C. Bridges (1925)
Sex in Relation to Chromosomes and GenesThe American Naturalist, 59
J. Birchler (2014)
Facts and artifacts in studies of gene expression in aneuploids and sex chromosomesChromosoma, 123
Casey McGrath, Jean-Francois Gout, T. Doak, A. Yanagi, M. Lynch (2014)
Insights into Three Whole-Genome Duplications Gleaned from the Paramecium caudatum Genome SequenceGenetics, 197
Americans Naturalist, J. Haldane, J. Innes (1933)
The Part Played by Recurrent Mutation in EvolutionThe American Naturalist, 67
N. Luscombe, M. Babu, Haiyuan Yu, M. Snyder, S. Teichmann, M. Gerstein (2004)
Genomic analysis of regulatory network dynamics reveals large topological changesNature, 431
R. Veitia (2010)
A generalized model of gene dosage and dominant negative effects in macromolecular complexesThe FASEB Journal, 24
B. Lemos, C. Meiklejohn, D. Hartl (2004)
Regulatory evolution across the protein interaction networkNature Genetics, 36
G. Blanc, K. Wolfe (2004)
Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis EvolutionThe Plant Cell Online, 16
A. Evangelisti, G. Conant (2010)
Nonrandom Survival of Gene Conversions among Yeast Ribosomal Proteins Duplicated through Genome DoublingGenome Biology and Evolution, 2
T. Makino, A. McLysaght (2010)
Ohnologs in the human genome are dosage balanced and frequently associated with diseaseProceedings of the National Academy of Sciences, 107
G. Perry, N. Dominy, Katrina Claw, Arthur Lee, H. Fiegler, R. Redon, John Werner, Fernando Villanea, J. Mountain, R. Misra, N. Carter, Charles Lee, A. Stone (2007)
Diet and the evolution of human amylase gene copy number variationNature Genetics, 39
U. Alon (2007)
Network motifs: theory and experimental approachesNature Reviews Genetics, 8
A. Wagner (2005)
Energy constraints on the evolution of gene expression.Molecular biology and evolution, 22 6
Andi Dhroso, Dmitry Korkin, G. Conant (2014)
The yeast protein interaction network has a capacity for self‐organizationThe FEBS Journal, 281
M. Lynch, J. Conery (2000)
The evolutionary fate and consequences of duplicate genes.Science, 290 5494
C. Disteche (2012)
Dosage compensation of the sex chromosomes.Annual review of genetics, 46
T. Makino, K. Hokamp, A. McLysaght (2009)
The complex relationship of gene duplication and essentiality.Trends in genetics : TIG, 25 4
M. Gelbart, M. Kuroda (2009)
Drosophila dosage compensation: a complex voyage to the X chromosome, 136
Daniel Stoebel, A. Dean, D. Dykhuizen (2008)
The Cost of Expression of Escherichia coli lac Operon Proteins Is in the Process, Not in the ProductsGenetics, 178
A. Blakeslee, J. Belling, M. Farnham (1920)
CHROMOSOMAL DUPLICATION AND MENDELIAN PHENOMENA IN DATURA MUTANTS.Science, 52
N. Barkai, S. Leibler (2000)
Biological rhythms: Circadian clocks limited by noiseNature, 403
Eduardo Torres, T. Sokolsky, C. Tucker, Leon Chan, Monica Boselli, Maitreya Dunham, A. Amon (2007)
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid YeastScience, 317
Steven Maere, Stefanie Bodt, J. Raes, T. Casneuf, M. Montagu, Martin Kuiper, Y. Peer (2005)
Modeling gene and genome duplications in eukaryotes.Proceedings of the National Academy of Sciences of the United States of America, 102 15
J. Birchler (2013)
Aneuploidy in plants and flies: the origin of studies of genomic imbalance.Seminars in cell & developmental biology, 24 4
C. Yanofsky, M. Rachmeler (1958)
The exclusion of free indole as an intermediate in the biosynthesis of tryptophan in Neurospora crassa.Biochimica et biophysica acta, 28 3
H. McAdams, A. Arkin (1997)
Stochastic mechanisms in gene expression.Proceedings of the National Academy of Sciences of the United States of America, 94 3
James Graham, T. Williams, Megan Morgan, A. Fernie, R. Ratcliffe, L. Sweetlove (2007)
Glycolytic Enzymes Associate Dynamically with Mitochondria in Response to Respiratory Demand and Support Substrate Channeling[W]The Plant Cell Online, 19
Attila Becskei, Benjamin Kaufmann, A. Oudenaarden (2005)
Contributions of low molecule number and chromosomal positioning to stochastic gene expressionNature Genetics, 37
J. Raser, E. O’Shea (2005)
Noise in Gene Expression: Origins, Consequences, and ControlScience, 309
E. Seppet, T. Kaambre, P. Sikk, T. Tiivel, H. Vija, Michael Tonkonogi, K. Sahlin, L. Kay, F. Appaix, U. Braun, M. Eimre, V. Saks (2001)
Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells.Biochimica et biophysica acta, 1504 2-3
T. Galitski, A. Saldanha, C. Styles, E. Lander, G. Fink (1999)
Ploidy regulation of gene expression.Science, 285 5425
I. Brandina, James Graham, C. Lemaître-Guillier, N. Entelis, I. Krasheninnikov, L. Sweetlove, I. Tarassov, R. Martin (2006)
Enolase takes part in a macromolecular complex associated to mitochondria in yeast.Biochimica et biophysica acta, 1757 9-10
C. Hyde, S. Ahmed, E. Padlan, E. Miles, David Davies (1988)
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.The Journal of biological chemistry, 263 33
J. Raser, E. O’Shea (2004)
Control of Stochasticity in Eukaryotic Gene ExpressionScience, 304
T. Hughes, C. Roberts, H. Dai, Allan Jones, Michael Meyer, D. Slade, J. Burchard, Sally Dow, T. Ward, M. Kidd, S. Friend, M. Marton (2000)
Widespread aneuploidy revealed by DNA microarray expression profilingNature Genetics, 25
N. Lane, W. Martin (2010)
The energetics of genome complexityNature, 467
M. Long (2006)
Faculty Opinions recommendation of The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene.
F. Mitelman (2000)
Recurrent chromosome aberrations in cancer.Mutation research, 462 2-3
Benjamin Schuster-Böckler, D. Conrad, A. Bateman (2010)
Dosage Sensitivity Shapes the Evolution of Copy-Number Varied RegionsPLoS ONE, 5
R. Veitia, J. Birchler (2015)
Models of buffering of dosage imbalances in protein complexesBiology Direct, 10
A. Wagner (2007)
Faculty Opinions recommendation of Increased glycolytic flux as an outcome of whole-genome duplication in yeast.
M. Lynch, J. Conery (2003)
The Origins of Genome ComplexityScience, 302
R. Veitia, M. Potier (2015)
Gene dosage imbalances: action, reaction, and models.Trends in biochemical sciences, 40 6
Michaël Bekaert, P. Edger, J. Pires, G. Conant (2011)
Two-Phase Resolution of Polyploidy in the Arabidopsis Metabolic Network Gives Rise to Relative and Absolute Dosage Constraints[W]Plant Cell, 23
L. Stadler (1929)
CHROMOSOME NUMBER AND THE MUTATION RATE IN AVENA AND TRITICUM.Proceedings of the National Academy of Sciences of the United States of America, 15 12
M. Hoek, P. Hogeweg (2009)
Metabolic adaptation after whole genome duplication.Molecular biology and evolution, 26 11
M. Nowak, M. Boerlijst, J. Cooke, John Smith (1997)
Evolution of genetic redundancyNature, 388
Richelle Sopko, Dongqing Huang, Nicolle Preston, G. Chua, Balázs Papp, Kimberly Kafadar, Michael Snyder, S. Oliver, M. Cyert, T. Hughes, Charles Boone, B. Andrews (2006)
Mapping pathways and phenotypes by systematic gene overexpression.Molecular cell, 21 3
The complex manner in which organisms respond to changes in their gene dosage has long fascinated geneticists. Oddly, although the existence of dominance implies that dosage reductions often have mild phenotypes, extra copies of whole chromosomes (aneuploidy) are generally strongly deleterious. Even more paradoxically, an extra copy of the genome is better tolerated than is aneuploidy. We review the resolution of this paradox, highlighting the roles of biochemistry, protein aggregation, and disruption of cellular microstructure in that explanation. Returning to life's curious combination of robustness and sensitivity to dosage changes, we argue that understanding how biological robustness evolved makes these observations less inexplicable. We propose that noise in gene expression and evolutionary strategies for its suppression play a role in generating dosage phenotypes. Finally, we outline an unappreciated mechanism for the preservation of duplicate genes, namely preservation to limit expression noise, arguing that it is particularly relevant in polyploid organisms.
Annual Review of Genetics – Annual Reviews
Published: Nov 23, 2016
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