Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. White, R. DiPaola (2009)
The Double-Edged Sword of Autophagy Modulation in CancerClinical Cancer Research, 15
William Dowdle, B. Nyfeler, Jane Nagel, Robert Elling, Shanming Liu, E. Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, G. Pardee, John Cantwell, Catherine Luu, Ivan Cornella-Taracido, Edmund Harrington, Peter Fekkes, Hong Lei, Qing Fang, M. Digan, Debra Burdick, Andrew Powers, S. Helliwell, Simon D’Aquin, Julie Bastien, Henry Wang, D. Wiederschain, Jenny Kuerth, Phil Bergman, David Schwalb, Jason Thomas, Savuth Ugwonali, Fred Harbinski, John Tallarico, Christopher Wilson, V. Myer, Jeffery Porter, D. Bussiere, P. Finan, Mark Labow, Xiaohong Mao, Lawrence Hamann, Brendan Manning, Reginald Valdez, Thomas Nicholson, M. Schirle, Mark Knapp, E. Keaney, Leon Murphy (2014)
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivoNature Cell Biology, 16
T. Valencia, Ji Kim, Shadi Abu-Baker, Jorge Moscat-Pardos, Christopher Ahn, M. Reina-Campos, A. Durán, Elias Castilla, Christian Metallo, Maria Diaz-Meco, J. Moscat (2014)
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.Cancer cell, 26 1
Zhen–Bin Ding, Bo Hui, Yinghong Shi, Jian Zhou, Yuan-fei Peng, Cheng-yu Gu, Hua Yang, G. Shi, A. Ke, Xiao-Ying Wang, K. Song, Z. Dai, Yinghao Shen, Jia Fan (2011)
Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species ModulationClinical Cancer Research, 17
(2006)
2006) has shown that when apoptosis and autophagy are inhibited, necrosis
C. Homewood, D. Warhurst, W. Peters, V. Baggaley (1972)
Lysosomes, pH and the Anti-malarial Action of ChloroquineNature, 235
J. Schneider, C. Sanchez (2016)
Autophagy and Metabolism
Hao Tang, Salwa Sebti, Rossella Titone, Yunyun Zhou, C. Isidoro, Theodora Ross, H. Hibshoosh, Guanghua Xiao, M. Packer, Yang Xie, B. Levine (2015)
Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor PrognosisEBioMedicine, 2
X. Liang, S. Jackson, M. Seaman, K. Brown, B. Kempkes, H. Hibshoosh, B. Levine (1999)
Induction of autophagy and inhibition of tumorigenesis by beclin 1Nature, 402
B. Boone, N. Bahary, A. Zureikat, A. Moser, D. Normolle, Wen-Chi Wu, A. Singhi, P. Bao, D. Bartlett, L. Liotta, V. Espina, P. Loughran, M. Lotze, H. Zeh (2015)
Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic AdenocarcinomaAnnals of Surgical Oncology, 22
N. Mizushima, Takeshi Noda, T. Yoshimori, Y. Tanaka, T. Ishii, Michael George, D. Klionsky, M. Ohsumi, Y. Ohsumi (1998)
A protein conjugation system essential for autophagyNature, 395
U. Santanam, Whitney Banach-Petrosky, C. Abate-Shen, M. Shen, E. White, R. DiPaola (2016)
Atg7 cooperates with Pten loss to drive prostate cancer tumor growthGenes & Development, 30
A. Jacquel, S. Obba, L. Boyer, M. Dufies, G. Robert, P. Gounon, E. Lemichez, F. Luciano, E. Solary, P. Auberger (2012)
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.Blood, 119 19
B. Wolpin, D. Rubinson, Xiaoxu Wang, J. Chan, J. Cleary, P. Enzinger, C. Fuchs, N. McCleary, J. Meyerhardt, K. Ng, D. Schrag, Allison Sikora, Beverly Spicer, L. Killion, H. Mamon, Alec Kimmelman (2014)
Phase II and pharmacodynamic study of autophagy inhibition using hydroxychloroquine in patients with metastatic pancreatic adenocarcinoma.The oncologist, 19 6
J. Mancias, Alec Kimmelman (2016)
Mechanisms of Selective Autophagy in Normal Physiology and Cancer.Journal of molecular biology, 428 9 Pt A
Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, Takeshi Noda, E. Kominami, Y. Ohsumi, T. Yoshimori (2000)
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingThe EMBO Journal, 19
(2015)
2015b). More direct evidence of a role for autophagy in suppressing tumor initiation
Maiko Ogata, S. Hino, A. Saito, Keisuke Morikawa, S. Kondo, S. Kanemoto, Tomohiko Murakami, M. Taniguchi, I. Tanii, K. Yoshinaga, Sadao Shiosaka, J. Hammarback, F. Urano, K. Imaizumi (2006)
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStressMolecular and Cellular Biology, 26
Akiko Kuma, M. Hatano, M. Matsui, A. Yamamoto, H. Nakaya, T. Yoshimori, Y. Ohsumi, T. Tokuhisa, N. Mizushima (2004)
The role of autophagy during the early neonatal starvation periodNature, 432
Christina Eng, Zuncai Wang, D. Tkach, L. Toral‐Barza, Savuth Ugwonali, Shanming Liu, S. Fitzgerald, Elizabeth George, Elizabeth Frias, Nadire Cochran, R. Jesus, Gregory McAllister, G. Hoffman, K. Bray, Luanna Lemon, J. Lucas, V. Fantin, R. Abraham, Leon Murphy, B. Nyfeler (2015)
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacyProceedings of the National Academy of Sciences, 113
H. Cheong, T. Lindsten, Junmin Wu, Chao Lu, C. Thompson (2011)
Ammonia-induced autophagy is independent of ULK1/ULK2 kinasesProceedings of the National Academy of Sciences, 108
M. Maiuri, Einat Zalckvar, A. Kimchi, Guido Kroemer (2007)
Self-eating and self-killing: crosstalk between autophagy and apoptosisNature Reviews Molecular Cell Biology, 8
Q. Fan, Christine Cheng, Christopher Hackett, M. Feldman, B. Houseman, T. Nicolaides, D. Haas-Kogan, C. James, Scott Oakes, Jayanta Debnath, K. Shokat, W. Weiss (2010)
Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant GliomaScience Signaling, 3
R. Lock, Srirupa Roy, C. Kenific, J. Su, E. Salas, S. Ronen, Jayanta Debnath (2011)
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformationMolecular Biology of the Cell, 22
C. Commisso, S. Davidson, Rengin Soydaner-Azeloglu, Seth Parker, Jurre Kamphorst, S. Hackett, Elda Grabocka, Michel Nofal, J. Drebin, C. Thompson, J. Rabinowitz, Christian Metallo, M. Heiden, D. Bar-Sagi (2013)
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cellsNature, 497
A. Takamura, M. Komatsu, Taichi Hara, A. Sakamoto, C. Kishi, S. Waguri, Y. Eishi, O. Hino, Keiji Tanaka, N. Mizushima (2011)
Autophagy-deficient mice develop multiple liver tumors.Genes & development, 25 8
Xiaoqi Xie, J. Koh, Sandy Price, E. White, J. Mehnert (2015)
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.Cancer discovery, 5 4
M. Feldman, Beth Apsel, A. Uotila, R. Loewith, Z. Knight, D. Ruggero, K. Shokat (2009)
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2PLoS Biology, 7
Huijun Wei, Shuang Wei, B. Gan, Xu Peng, W. Zou, J. Guan (2011)
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.Genes & development, 25 14
Vanessa Hubbard, Rut Valdor, Bindi Patel, Rajat Singh, A. Cuervo, F. Macian (2010)
Activation Metabolism during Effector T Cell Macroautophagy Regulates Energy
C. Sousa, Douglas Biancur, Xiaoxu Wang, Christopher Halbrook, M. Sherman, Li Zhang, Daniel Kremer, R. Hwang, Agnes Witkiewicz, H. Ying, J. Asara, Ronald Evans, L. Cantley, C. Lyssiotis, Alec Kimmelman (2016)
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretionNature, 536
Ruth Scherz-Shouval, E. Shvets, E. Fass, Hagai Shorer, L. Gil, Z. Elazar (2007)
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4The EMBO Journal, 26
T. Münster, J. Gibbs, da-you Shen, B. Baethge, G. Botstein, J. Caldwell, F. Dietz, R. Ettlinger, H. Golden, H. Lindsley, G. Mclaughlin, L. Moreland, W. Roberts, T. Rooney, B. Rothschild, M. Sack, A. Sebba, M. Weisman, Kathryn Welch, D. Yocum, D. Furst, D. Furst (2002)
Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis.Arthritis and rheumatism, 46 6
S. Laddha, S. Ganesan, Chang Chan, E. White (2014)
Mutational Landscape of the Essential Autophagy Gene BECN1 in Human CancersMolecular Cancer Research, 12
R. Mathew, C. Karp, Brian Beaudoin, N. Vuong, Guanghua Chen, Hsin Chen, K. Bray, Anupama Reddy, G. Bhanot, C. Gélinas, R. DiPaola, V. Karantza-Wadsworth, E. White (2011)
Autophagy Suppresses Tumorigenesis through Elimination of p62Cell, 145
(2014)
PDAC mouse models have demonstrated that although tumor formation is decreased, those tumors that do manage to form no longer require autophagy
J. Guo, B. Xia, E. White (2013)
Autophagy-Mediated Tumor PromotionCell, 155
Carson Thoreen, S. Kang, J. Chang, Qingsong Liu, Jianming Zhang, Yi Gao, L. Reichling, Taebo Sim, D. Sabatini, N. Gray (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1*Journal of Biological Chemistry, 284
(2013)
With the loss of functional p53 seen in many tumors, the expec
Katy Petherick, Owen Conway, C. Mpamhanga, S. Osborne, Ahmad Kamal, B. Saxty, I. Ganley (2015)
Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy*The Journal of Biological Chemistry, 290
Rajat Singh, Susmita Kaushik, Yongjun Wang, Youqing Xiang, Inna Novak, M. Komatsu, Keiji Tanaka, A. Cuervo, M. Czaja (2009)
Autophagy regulates lipid metabolismNature, 458
M. Rosenfeldt, J. O'prey, J. Morton, C. Nixon, G. Mackay, Agata Mrowinska, Amy Au, T. Rai, Liang Zheng, R. Ridgway, P. Adams, K. Anderson, E. Gottlieb, O. Sansom, K. Ryan (2013)
p53 status determines the role of autophagy in pancreatic tumour developmentNature, 504
K. Zhu, K. Dunner, D. McConkey (2009)
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cellsOncogene, 29
Aliaksandr Khaminets, C. Behl, I. Dikič (2016)
Ubiquitin-Dependent And Independent Signals In Selective Autophagy.Trends in cell biology, 26 1
P. Voziyan, Eugenia Yazlovitskaya (2014)
Reactive Oxygen SpeciesJournal of Bioequivalence & Bioavailability, 2014
Shuan Rao, L. Tortola, Thomas Perlot, Gerald Wirnsberger, M. Novatchkova, R. Nitsch, P. Sykacek, Lukas Frank, D. Schramek, Vukoslav Komnenovic, Verena Sigl, Karin Aumayr, Gerald Schmauss, Nicole Fellner, S. Handschuh, M. Glösmann, P. Pasierbek, M. Schlederer, G. Resch, Yuting Ma, H. Yang, H. Popper, L. Kenner, G. Kroemer, J. Penninger (2014)
A dual role for autophagy in a murine model of lung cancerNature Communications, 5
S. Pattingre, L. Espert, M. Biard-Piechaczyk, P. Codogno (2008)
Regulation of macroautophagy by mTOR and Beclin 1 complexes.Biochimie, 90 2
H. Takeuchi, Y. Kondo, K. Fujiwara, T. Kanzawa, H. Aoki, G. Mills, S. Kondo (2005)
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.Cancer research, 65 8
N. Noda, F. Inagaki (2015)
Mechanisms of Autophagy.Annual review of biophysics, 44
G. Karsli-Uzunbas, J. Guo, Sandy Price, Xin Teng, S. Laddha, Sinan Khor, Nada Kalaany, T. Jacks, Chang Chan, J. Rabinowitz, E. White (2014)
Autophagy is required for glucose homeostasis and lung tumor maintenance.Cancer discovery, 4 8
R. Bago, Nazma Malik, Michael Munson, A. Prescott, Paul Davies, E. Sommer, N. Shpiro, R. Ward, D. Cross, I. Ganley, D. Alessi (2014)
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinaseBiochemical Journal, 463
Jun Fu, Cui-jie Shao, Fu‐rong Chen, H. Ng, Zhongwu Chen (2010)
Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines.Neuro-oncology, 12 4
(2009)
Interestingly, amplification of chromosome 5q, where p62
Dennis Goussetis, J. Altman, H. Glaser, Jennifer McNeer, M. Tallman, L. Platanias (2010)
Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide*The Journal of Biological Chemistry, 285
A. Criollo, L. Senovilla, H. Authier, M. Maiuri, E. Morselli, I. Vitale, O. Kepp, E. Tasdemir, L. Galluzzi, Shensi Shen, M. Tailler, N. Delahaye, A. Tesnière, D. Stefano, A. Younes, F. Harper, G. Pierron, S. Lavandero, L. Zitvogel, A. Israel, V. Baud, G. Kroemer (2010)
The IKK complex contributes to the induction of autophagyThe EMBO Journal, 29
R. Lazova, R. Camp, V. Klump, Summar Siddiqui, R. Amaravadi, J. Pawelek (2011)
Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor OutcomeClinical Cancer Research, 18
G. Semenza (2010)
HIF-1: upstream and downstream of cancer metabolism.Current opinion in genetics & development, 20 1
Shenghong Yang, Xiaoxu Wang, G. Contino, M. Liesa, Ergun Sahin, H. Ying, Alexandra Bause, Yinghua Li, J. Stommel, G. Dell’Antonio, J. Mautner, G. Tonon, M. Haigis, O. Shirihai, C. Doglioni, N. Bardeesy, Alec Kimmelman (2011)
Pancreatic cancers require autophagy for tumor growth.Genes & development, 25 7
R. Lock, C. Kenific, Andrew Leidal, E. Salas, Jayanta Debnath (2014)
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion.Cancer discovery, 4 4
A. Yang, N. Rajeshkumar, Xiaoxu Wang, S. Yabuuchi, S. Yabuuchi, B. Alexander, Gerald Chu, D. Hoff, A. Maitra, A. Maitra, Alec Kimmelman (2014)
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.Cancer discovery, 4 8
(2011)
Ionizing radiation induces autophagy
J. Mancias, Alec Kimmelman (2011)
Targeting Autophagy Addiction in CancerOncotarget, 2
G. Ruiz‐Irastorza, M. Ramos-Casals, P. Brito‐Zerón, M. Khamashta (2008)
Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic reviewAnnals of the Rheumatic Diseases, 69
N. Mizushima (2010)
The role of the Atg1/ULK1 complex in autophagy regulation.Current opinion in cell biology, 22 2
(2007)
AKT inhibition (Degtyarev et al. 2008), and tyrosine kinase inhibitors
M. Rosenfeld, X. Ye, J. Supko, S. Desideri, S. Grossman, S. Brem, T. Mikkelson, Daniel Wang, Y. Chang, Janice Hu, Q. McAfee, J. Fisher, A. Troxel, Shengfu Piao, D. Heitjan, K. Tan, L. Pontiggia, P. O'dwyer, L. Davis, R. Amaravadi (2014)
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiformeAutophagy, 10
Daniel Egan, D. Shackelford, M. Mihaylova, Sara Gelino, Rebecca Kohnz, William Mair, Debbie Vasquez, Aashish Joshi, Dana Gwinn, Rebecca Taylor, J. Asara, J. Fitzpatrick, A. Dillin, B. Viollet, M. Kundu, M. Hansen, R. Shaw (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to MitophagyScience, 331
Yanying Huo, H. Cai, I. Teplova, Christian Bowman-Colin, Guanghua Chen, Sandy Price, N. Barnard, S. Ganesan, V. Karantza, E. White, B. Xia (2013)
Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.Cancer discovery, 3 8
Y. Kouroku, E. Fujita, I. Tanida, T. Ueno, A. Isoai, H. Kumagai, S. Ogawa, R. Kaufman, E. Kominami, T. Momoi (2007)
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formationCell Death and Differentiation, 14
(2007)
2007), to name a few. In some instances, the molecular mechanisms of autophagy activation in response to the cancer
(2015)
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolismNature, 524
Matthew Sorbara, S. Girardin (2015)
Emerging themes in bacterial autophagy.Current opinion in microbiology, 23
D. Rubinsztein, P. Codogno, B. Levine (2012)
Autophagy modulation as a potential therapeutic target for diverse diseasesNature Reviews Drug Discovery, 11
J. Guo, Hsin-Yi Chen, R. Mathew, Jing Fan, A. Strohecker, G. Karsli-Uzunbas, Jurre Kamphorst, Guanghua Chen, Johanna Lemons, V. Karantza, H. Coller, R. DiPaola, C. Gélinas, J. Rabinowitz, E. White (2011)
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.Genes & development, 25 5
K. Satoo, N. Noda, H. Kumeta, Y. Fujioka, N. Mizushima, Y. Ohsumi, F. Inagaki (2009)
The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagyThe EMBO Journal, 28
(2013)
An unconventional MIIC-driven autophagic pathway operational in dendritic cells
A. Choi, S. Ryter, B. Levine (2013)
Autophagy in human health and disease.The New England journal of medicine, 368 7
V. Karantza-Wadsworth, S. Patel, O. Kravchuk, Guanghua Chen, R. Mathew, Shengkan Jin, E. White (2007)
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.Genes & development, 21 13
M. Abedin, Dehua Wang, M. McDonnell, U. Lehmann, A. Kelekar (2007)
Autophagy delays apoptotic death in breast cancer cells following DNA damageCell Death and Differentiation, 14
Laura Poillet-Perez, G. Despouy, R. Delage-Mourroux, Michaël Boyer-Guittaut (2014)
Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapyRedox Biology, 4
Daniel Papinski, Martina Schuschnig, W. Reiter, Larissa Wilhelm, C. Barnes, A. Maiolica, I. Hansmann, Thaddaeus Pfaffenwimmer, M. Kijanska, Ingrid Stoffel, Sung Lee, Andrea Brezovich, Jane Lou, B. Turk, R. Aebersold, G. Ammerer, M. Peter, C. Kraft (2014)
Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 KinaseMolecular Cell, 53
B. Ronan, O. Flamand, Lionel Vescovi, C. Dureuil, L. Durand, F. Fassy, M. Bachelot, A. Lamberton, M. Mathieu, T. Bertrand, J. Marquette, Y. El-Ahmad, Bruno Filoche-Rommé, Laurent Schio, C. García-echeverría, H. Goulaouic, B. Pasquier (2014)
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.Nature chemical biology, 10 12
(2014)
mammalian target of rapamycin (mTOR)] (Galluzzi et
R. González-Polo, P. Boya, Anne-Laure Pauleau, Abdelali Jalil, N. Larochette, S. Souquere, E. Eskelinen, G. Pierron, P. Saftig, G. Kroemer (2005)
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic deathJournal of Cell Science, 118
A. Strohecker, J. Guo, G. Karsli-Uzunbas, Sandy Price, Guanghua Chen, R. Mathew, M. McMahon, E. White (2013)
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.Cancer discovery, 3 11
Y. Nishida, Satoko Arakawa, Kenji Fujitani, Hirofumi Yamaguchi, Takeshi Mizuta, T. Kanaseki, M. Komatsu, K. Otsu, Y. Tsujimoto, S. Shimizu (2009)
Discovery of Atg5/Atg7-independent alternative macroautophagyNature, 461
Aliaksandr Khaminets, Theresa Heinrich, M. Mari, P. Grumati, A. Huebner, M. Akutsu, L. Liebmann, Alexandra Stolz, S. Nietzsche, Nicole Koch, Mario Mauthe, I. Katona, B. Qualmann, J. Weis, F. Reggiori, I. Kurth, C. Hübner, I. Dikič (2015)
Regulation of endoplasmic reticulum turnover by selective autophagyNature, 522
Juanjuan Tang, J. Di, H. Cao, J. Bai, Junnian Zheng (2015)
p53-mediated autophagic regulation: A prospective strategy for cancer therapy.Cancer letters, 363 2
Alexa Ertmer, V. Huber, S. Gilch, Tamotsu Yoshimori, Volker Erfle, Justus Duyster, Hans-Peter Elsässer, Hermann Schätzl (2007)
The anticancer drug imatinib induces cellular autophagyLeukemia, 21
J. Moscat, M. Diaz-Meco (2009)
p62 at the Crossroads of Autophagy, Apoptosis, and CancerCell, 137
C. Jung, Chang-Bong Jun, Seung-Hyun Ro, Young-Mi Kim, N. Otto, Jing Cao, M. Kundu, Do-Hyung Kim (2009)
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.Molecular biology of the cell, 20 7
Heather Pua, I. Dzhagalov, Mariana Chuck, N. Mizushima, You-Wen He (2007)
A critical role for the autophagy gene Atg5 in T cell survival and proliferationThe Journal of Experimental Medicine, 204
J. Guo, G. Karsli-Uzunbas, R. Mathew, S. Aisner, Jurre Kamphorst, A. Strohecker, Guanghua Chen, Sandy Price, Wenyun Lu, Xin Teng, E. Snyder, U. Santanam, R. DiPaola, T. Jacks, J. Rabinowitz, E. White (2013)
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis.Genes & development, 27 13
Hideaki Ito, S. Daido, T. Kanzawa, S. Kondo, Y. Kondo (2005)
Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells.International journal of oncology, 26 5
Sandra Turcotte, D. Chan, P. Sutphin, M. Hay, W. Denny, A. Giaccia (2008)
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.Cancer cell, 14 1
Chang Jung, Seung-Hyun Ro, Jing Cao, N. Otto, Do-Hyung Kim (2010)
mTOR regulation of autophagyFEBS Letters, 584
Joell Gills, J. LoPiccolo, P. Dennis (2008)
Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagyAutophagy, 4
(2009)
In fact, autophagy blockade by liver-specific Atg7 knockout leads
(2015)
In one example, autophagy-dependent secretion
(2013)
For an in-depth review of the subject, including the growing 22 Santana-Codina
V. Solomon, Changkun Hu, Hoyun Lee (2010)
Design and synthesis of chloroquine analogs with anti-breast cancer property.European journal of medicinal chemistry, 45 9
K. Degenhardt, R. Mathew, Brian Beaudoin, K. Bray, Diana Anderson, Guanghua Chen, Chandreyee Mukherjee, Yufang Shi, C. Gélinas, Yongjun Fan, D. Nelson, Shengkan Jin, E. White (2006)
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.Cancer cell, 10 1
Ker Yu, C. Shi, L. Toral‐Barza, J. Lucas, Boris Shor, Jae Kim, Wei-Guo Zhang, R. Mahoney, Christine Gaydos, L. Tardio, Sung Kim, R. Conant, K. Curran, Joshua Kaplan, J. Verheijen, S. Ayral-Kaloustian, T. Mansour, R. Abraham, A. Zask, J. Gibbons (2010)
Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer research, 70 2
Kosuke Sakitani, Y. Hirata, Yohko Hikiba, Y. Hayakawa, Sozaburo Ihara, Hirobumi Suzuki, Nobumi Suzuki, T. Serizawa, Hiroto Kinoshita, K. Sakamoto, Hayato Nakagawa, K. Tateishi, S. Maeda, T. Ikenoue, S. Kawazu, K. Koike (2015)
Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stressBMC Cancer, 15
Pui-Mun wong, Yan Feng, Junru Wang, Rong Shi, Xuejun Jiang (2015)
Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2ANature Communications, 6
Rajat Singh, A. Cuervo (2011)
Autophagy in the cellular energetic balance.Cell metabolism, 13 5
(2015)
Nuclear p53 has been proposed to activate autophagy
D. Hanahan, R. Weinberg (2011)
Hallmarks of Cancer: The Next GenerationCell, 144
Zhixun Dou, Caiyue Xu, G. Donahue, T. Shimi, Ji-An Pan, Jiajun Zhu, Andrejs Ivanov, Brian Capell, Adam Drake, P. Shah, Joseph Catanzaro, M. Ricketts, T. Lamark, S. Adam, R. Marmorstein, W. Zong, T. Johansen, R. Goldman, P. Adams, S. Berger (2015)
Autophagy mediates degradation of nuclear laminaNature, 527
Zhaoyu Jin, Yun Li, R. Pitti, D. Lawrence, Victoria Pham, J. Lill, A. Ashkenazi (2009)
Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis SignalingCell, 137
A. Young, M. Narita, Manuela Ferreira, K. Kirschner, Mahito Sadaie, Jeremy Darot, S. Tavaré, Satoko Arakawa, S. Shimizu, F. Watt, M. Narita (2009)
Autophagy mediates the mitotic senescence transition.Genes & development, 23 7
C. Sousa, Douglas Biancur, Xiaoxu Wang, Christopher Halbrook, M. Sherman, Li Zhang, Daniel Kremer, R. Hwang, Agnes Witkiewicz, H. Ying, J. Asara, Ronald Evans, L. Cantley, C. Lyssiotis, Alec Kimmelman (2016)
Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretionNature, 540
Y. Inami, S. Waguri, A. Sakamoto, T. Kouno, K. Nakada, O. Hino, Sumio Watanabe, J. Ando, M. Iwadate, Masayuki Yamamoto, Myung-Shik Lee, Keiji Tanaka, M. Komatsu (2011)
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cellsThe Journal of Cell Biology, 193
Yufang Shao, Zhonghua Gao, P. Marks, Xuejun Jiang (2004)
Apoptotic and autophagic cell death induced by histone deacetylase inhibitorsProceedings of the National Academy of Sciences of the United States of America, 101
H. Maes, N. Rubio, Abhishek Garg, P. Agostinis (2013)
Autophagy: shaping the tumor microenvironment and therapeutic response.Trends in molecular medicine, 19 7
(2014)
Combined MTOR and autophagy inhibitionAutophagy, 10
J. Levy, J. Thompson, A. Griesinger, V. Amani, A. Donson, D. Birks, M. Morgan, D. Mirsky, M. Handler, N. Foreman, A. Thorburn (2014)
Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.Cancer discovery, 4 7
(2015)
Two additional forms of autophagy, microautophagy and chaperone
M. Maiuri, E. Tasdemir, E. Tasdemir, A. Criollo, A. Criollo, E. Morselli, E. Morselli, J. Vicencio, J. Vicencio, R. Carnuccio, G. Kroemer, G. Kroemer (2009)
Control of autophagy by oncogenes and tumor suppressor genesCell Death and Differentiation, 16
J. Levy, A. Thorburn (2011)
Targeting autophagy during cancer therapy to improve clinical outcomes.Pharmacology & therapeutics, 131 1
(2015)
Prostate Nkx3.1CreERT2/+; Ptenflox/flox
Junli Liu, Hongguang Xia, Minsu Kim, Li-hua Xu, Y. Li, Lihong Zhang, Yu Cai, H. Norberg, Tao Zhang, T. Furuya, Minzhi Jin, Zhimin Zhu, Huanchen Wang, Jia Yu, Yanxia Li, Y. Hao, Augustine Choi, H. Ke, D. Ma, Junying Yuan (2011)
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13Cell, 147
Moran Slobodkin, Z. Elazar (2013)
The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy.Essays in biochemistry, 55
Jasvinder Kaur, Jayanta Debnath (2015)
Autophagy at the crossroads of catabolism and anabolismNature Reviews Molecular Cell Biology, 16
M. Buzzai, Russell Jones, R. Amaravadi, J. Lum, R. Deberardinis, F. Zhao, B. Viollet, C. Thompson (2007)
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.Cancer research, 67 14
C. Chresta, B. Davies, Ian Hickson, Tom Harding, S. Cosulich, S. Critchlow, J. Vincent, Rebecca Ellston, Darren Jones, P. Sini, D. James, Z. Howard, Phillippa Dudley, G. Hughes, Lisa Smith, Sharon Maguire, M. Hummersone, Karine Malagu, K. Menear, R. Jenkins, Matt Jacobsen, G. Smith, S. Guichard, M. Pass (2010)
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.Cancer research, 70 1
Ruth Scherz-Shouval, Z. Elazar (2007)
ROS, mitochondria and the regulation of autophagy.Trends in cell biology, 17 9
Yi Zhang, Yan Cheng, X. Ren, Li Zhang, K. Yap, Hao Wu, R. Patel, David Liu, Zheng-Hong Qin, I. Shih, Jin-Ming Yang (2011)
NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin via Altering the HMGB1-Mediated Autophagic Response*Oncogene, 31
T. Willinger, R. Flavell (2012)
Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasisProceedings of the National Academy of Sciences, 109
Siân Jones, Xiaosong Zhang, D. Parsons, Jimmy Lin, R. Leary, P. Angenendt, P. Mankoo, H. Carter, H. Kamiyama, A. Jimeno, Seung‐Mo Hong, Baojin Fu, Ming-Tseh Lin, E. Calhoun, M. Kamiyama, K. Walter, T. Nikolskaya, Y. Nikolsky, James Hartigan, Douglas Smith, M. Hidalgo, S. Leach, A. Klein, E. Jaffee, M. Goggins, A. Maitra, C. Iacobuzio-Donahue, J. Eshleman, S. Kern, R. Hruban, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. Velculescu, K. Kinzler (2008)
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic AnalysesScience, 321
I. Ben-Sahra, K. Laurent, S. Giuliano, F. Larbret, G. Ponzio, P. Gounon, Y. Marchand-Brustel, S. Giorgetti-Peraldi, M. Cormont, C. Bertolotto, M. Deckert, P. Auberger, J. Tanti, F. Bost (2010)
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.Cancer research, 70 6
D. Gewirtz (2009)
Autophagy, senescence and tumor dormancy in cancer therapyAutophagy, 5
R. Mathew, V. Karantza-Wadsworth, E. White (2007)
Role of autophagy in cancerNature Reviews Cancer, 7
M. Degtyarev, A. Mazière, C. Orr, Jie Lin, Brian Lee, Janet Tien, W. Prior, Suzanne Dijk, Hong Wu, Daniel Gray, David Davis, H. Stern, Lesley Murray, K. Hoeflich, J. Klumperman, L. Friedman, Kui Lin (2008)
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agentsThe Journal of Cell Biology, 183
Q. Zhong (2015)
Faculty Opinions recommendation of Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.
(2014)
A.C.K. J.D.M. is supported by a KL2/Catalyst Medical Research Investigator Training award (TR001100) and a Burroughs Wellcome Fund Career Award for Medical Scientists
R. Kalluri, M. Zeisberg (2006)
Fibroblasts in cancerNature Reviews Cancer, 6
M. Rosenfeld, S. Grossman, S. Brem, T. Mikkelsen, D. Wang, Shengfu Piao, L. Davis, P. O'dwyer, R. Amaravadi (2010)
Pharmacokinetic analysis and pharmacodynamic evidence of autophagy inhibition in patients with newly diagnosed glioblastoma treated on a phase I trial of hydroxychloroquine in combination with adjuvant temozolomide and radiation (ABTC 0603).Journal of Clinical Oncology, 28
C. Duve, R. Wattiaux (1966)
Functions of lysosomes.Annual review of physiology, 28
Jonathan Levy, W. Cacheux, Medhi Bara, Antoine L’Hermitte, P. Lepage, Marie Fraudeau, Coralie Trentesaux, J. Lemarchand, A. Durand, Anne-Marie Crain, C. Marchiol, G. Renault, F. Dumont, F. Letourneur, M. Delacre, A. Schmitt, B. Terris, C. Perret, M. Chamaillard, J. Couty, B. Romagnolo (2015)
Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growthNature Cell Biology, 17
R. Amaravadi, Duonan Yu, J. Lum, Thi Bui, M. Christophorou, G. Evan, A. Thomas-Tikhonenko, C. Thompson (2007)
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.The Journal of clinical investigation, 117 2
(2016)
The majority of the trials have used a combination
(2004)
Therefore, in a tumor’s hypoxic regions, autophagy is usually elevated and promotes cell survival
J. Carew, S. Nawrocki, C. Kahue, Hui Zhang, Chunying Yang, Linda Chung, J. Houghton, Peng Huang, F. Giles, J. Cleveland (2007)
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.Blood, 110 1
Yuan-Ling Liu, Pei-Ming Yang, C. Shun, Ming-Shiang Wu, J. Weng, Ching‐Chow Chen (2010)
Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinomaAutophagy, 6
N. Mizushima, M. Komatsu (2011)
Autophagy: Renovation of Cells and TissuesCell, 147
Martin Ondrej, Lucie Čecháková, Kamila Ďurišová, J. Pejchal, A. Tichý (2016)
To live or let die: Unclear task of autophagy in the radiosensitization battle.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 119 2
J. Mancias, Xiaoxu Wang, S. Gygi, J. Harper, Alec Kimmelman (2014)
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagyNature, 509
S. Tett, R. Day, D. Cutler (1993)
Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis--a cross sectional study.The Journal of rheumatology, 20 11
(2015)
promote autophagy initiation. ULK1–2 is also activated at low energy states by phosphorylation via AMPK
Daniela Brož, Stephano Mello, K. Bieging, D. Jiang, R. Dusek, Colleen Brady, A. Sidow, L. Attardi (2013)
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses.Genes & development, 27 9
A. Durán, J. Linares, A. Gálvez, K. Wikenheiser, J. Flores, M. Diaz-Meco, J. Moscat (2008)
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.Cancer cell, 13 4
(2007)
Surg. Oncol
H. Ushio, T. Ueno, Y. Kojima, M. Komatsu, Satoshi Tanaka, A. Yamamoto, Yoshinobu Ichimura, J. Ezaki, K. Nishida, S. Komazawa-Sakon, F. Niyonsaba, T. Ishii, T. Yanagawa, E. Kominami, H. Ogawa, K. Okumura, H. Nakano (2011)
Crucial role for autophagy in degranulation of mast cells.The Journal of allergy and clinical immunology, 127 5
Zhen Lu, R. Luo, Yiling Lu, Xuhui Zhang, Qinghua Yu, Shilpi Khare, S. Kondo, Y. Kondo, Yin-hua Yu, G. Mills, W. Liao, R. Bast (2008)
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.The Journal of clinical investigation, 118 12
Christian Behrends, M. Sowa, S. Gygi, J. Harper (2010)
Network organization of the human autophagy systemNature, 466
Wen-wen Li, Jian Li, J. Bao (2012)
Microautophagy: lesser-known self-eatingCellular and Molecular Life Sciences, 69
J. Ewald, Joshua Desotelle, G. Wilding, D. Jarrard (2010)
Therapy-induced senescence in cancer.Journal of the National Cancer Institute, 102 20
Chandra Lebovitz, A. Robertson, R. Goya, S. Jones, Ryan Morin, M. Marra, S. Gorski (2015)
Cross-cancer profiling of molecular alterations within the human autophagy interaction networkAutophagy, 11
P. Pérez-Mancera, A. Young, M. Narita (2014)
Inside and out: the activities of senescence in cancerNature Reviews Cancer, 14
J. Dengjel, O. Schoor, R. Fischer, Michael Reich, M. Kraus, Margret Müller, Katharina Kreymborg, F. Altenberend, J. Brandenburg, H. Kalbacher, R. Brock, C. Driessen, H. Rammensee, S. Stevanović (2005)
Autophagy promotes MHC class II presentation of peptides from intracellular source proteinsProceedings of the National Academy of Sciences of the United States of America, 102
R. Mathew, S. Kongara, Brian Beaudoin, C. Karp, K. Bray, K. Degenhardt, Guanghua Chen, Shengkan Jin, E. White (2007)
Autophagy suppresses tumor progression by limiting chromosomal instability.Genes & development, 21 11
Lianjie Li, Chuan Shen, E. Nakamura, K. Ando, S. Signoretti, R. Beroukhim, G. Cowley, Patrick Lizotte, E. Liberzon, S. Bair, D. Root, P. Tamayo, Aviad Tsherniak, Su-Chun Cheng, B. Tabak, A. Jacobsen, A. Hakimi, N. Schultz, G. Ciriello, C. Sander, J. Hsieh, W. Kaelin (2013)
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.Cancer cell, 24 6
M. Michaud, I. Martins, Abdul Sukkurwala, Sandy Adjemian, Yuting Ma, P. Pellegatti, Shensi Shen, O. Kepp, Marie Scoazec, G. Mignot, S. Rello-Varona, M. Tailler, Laurie Menger, E. Vacchelli, L. Galluzzi, F. Ghiringhelli, F. Virgilio, L. Zitvogel, G. Kroemer (2011)
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in MiceScience, 334
R. Stupp, Warren Mason, M. Bent, M. Weller, B. Fisher, M. Taphoorn, K. Bélanger, A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, Robert Janzer, Samuel Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J. Cairncross, E. Eisenhauer, R. Mirimanoff (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.The New England journal of medicine, 352 10
B. Levine, Sangita Sinha, G. Kroemer (2008)
Bcl-2 family members: Dual regulators of apoptosis and autophagyAutophagy, 4
(2015)
Human PDAC cells can also induce autophagy via a MiT/TFE
Megan Goodall, Tong Wang, Katie Martin, M. Kortus, Audra Kauffman, J. Trent, S. Gately, J. MacKeigan (2014)
Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenibAutophagy, 10
J. Carew, C. Espitia, J. Esquivel, D. Mahalingam, K. Kelly, G. Reddy, F. Giles, S. Nawrocki (2010)
Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis*The Journal of Biological Chemistry, 286
(2011)
Similar results have been obtained in an Apc+/−
(2007)
Despite the possible clinical activity of HCQ
(2006)
The initial studies of the autophagy
D. Hardie, Fiona Ross, S. Hawley (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasisNature Reviews Molecular Cell Biology, 13
B. Pasquier, Y. El-Ahmad, Bruno Filoche-Rommé, C. Dureuil, F. Fassy, P. Abecassis, M. Mathieu, T. Bertrand, T. Bénard, C. Barrière, Samira Batti, Jean-Philippe Letallec, Véronique Sonnefraud, M. Brollo, L. Delbarre, Véronique Loyau, Fabienne Pilorge, L. Bertin, Patrick Richepin, J. Arigon, J. Labrosse, J. Clément, Florence Durand, Romain Combet, P. Perraut, Vincent Leroy, F. Gay, Dominique Lefrançois, F. Bretin, J. Marquette, N. Michot, A. Caron, Christelle Castell, Laurent Schio, G. Mccort, H. Goulaouic, C. García-echeverría, B. Ronan (2014)
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.Journal of medicinal chemistry, 58 1
A. Cuervo, E. Wong (2013)
Chaperone-mediated autophagy: roles in disease and agingCell Research, 24
J. Imlay, J. Imlay, S. Linn (1988)
DNA damage and oxygen radical toxicity.Science, 240 4857
J. Carew, E. Medina, Juan II, D. Mahalingam, R. Swords, K. Kelly, Hui Zhang, Peng Huang, A. Mita, M. Mita, F. Giles, S. Nawrocki (2009)
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulationJournal of Cellular and Molecular Medicine, 14
Daniel Egan, M. Chun, Mitchell Vamos, Haixia Zou, Juan Rong, Chad Miller, H. Lou, Dhanya Raveendra-Panickar, chih‐cheng yang, D. Sheffler, P. Teriete, J. Asara, B. Turk, N. Cosford, R. Shaw (2015)
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.Molecular cell, 59 2
Sung Kim, M. Overholtzer (2013)
Autophagy proteins regulate cell engulfment mechanisms that participate in cancer.Seminars in cancer biology, 23 5
M. Stein, Hongxia Lin, C. Jeyamohan, D. Dvorzhinski, M. Gounder, K. Bray, S. Eddy, S. Goodin, E. White, R. DiPaola (2010)
Targeting tumor metabolism with 2‐deoxyglucose in patients with castrate‐resistant prostate cancer and advanced malignanciesThe Prostate, 70
Zhenyu Yue, Shengkan Jin, Ching-Pa Yang, A. Levine, N. Heintz (2003)
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressorProceedings of the National Academy of Sciences of the United States of America, 100
L. Galluzzi, F. Pietrocola, B. Levine, G. Kroemer (2014)
Metabolic Control of AutophagyCell, 159
(2006)
Studies on the selective autophagy receptor
Min-Jung Kim, Soo-Jung Woo, Chang-Hwan Yoon, Jae-Seong Lee, S. An, Yung-Hyun Choi, Sang-Gu Hwang, G. Yoon, Su-Jae Lee (2011)
Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell TransformationThe Journal of Biological Chemistry, 286
(2012)
Although autophagy was initially thought to be a bulk, nonselective degradative pathway
(2016)
Colon VilCre-ERT2 Apcflox/+ Atg7
D. Akin, S Wang, Pouran Habibzadegah-Tari, B. Law, D. Ostrov, Min Li, Xiao-Ming Yin, Jae‐Sung Kim, N. Horenstein, W. Dunn (2014)
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumorsAutophagy, 10
Zhifen Yang, D. Klionsky (2010)
Eaten alive: a history of macroautophagyNature Cell Biology, 12
Cheng Wang, Qidong Hu, Han-Ming Shen (2016)
Pharmacological inhibitors of autophagy as novel cancer therapeutic agents.Pharmacological research, 105
D. Klionsky, B. Schulman (2014)
Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteinsNature Structural &Molecular Biology, 21
H. Mukubou, T. Tsujimura, R. Sasaki, Y. Ku (2010)
The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation.International journal of oncology, 37 4
A. Biankin, N. Waddell, K. Kassahn, M. Gingras, L. Muthuswamy, A. Johns, David Miller, P. Wilson, A. Patch, Jianmin Wu, D. Chang, M. Cowley, B. Gardiner, Sarah Song, Ivon Harliwong, S. Idrisoglu, C. Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, M. Gongora, M. Pajic, C. Scarlett, A. Gill, Andreia Pinho, I. Rooman, M. Anderson, O. Holmes, C. Leonard, Darrin Taylor, S. Wood, Qinying Xu, K. Nones, J. Fink, Angelika Christ, T. Bruxner, N. Cloonan, G. Kolle, F. Newell, M. Pinese, R. Mead, J. Humphris, W. Kaplan, Marc Jones, E. Colvin, A. Nagrial, Emily Humphrey, A. Chou, V. Chin, L. Chantrill, A. Mawson, J. Samra, J. Kench, Jessica Lovell, R. Daly, N. Merrett, C. Toon, K. Epari, N. Nguyen, A. Barbour, N. Zeps, N. Kakkar, Fengmei Zhao, Y. Wu, Min Wang, D. Muzny, W. Fisher, F. Brunicardi, S. Hodges, J. Reid, J. Drummond, K. Chang, Yi Han, L. Lewis, H. Dinh, C. Buhay, T. Beck, Lee Timms, M. Sam, K. Begley, Andrew Brown, D. Pai, A. Panchal, Nicholas Buchner, R. Borja, R. Denroche, C. Yung, S. Serra, N. Onetto, D. Mukhopadhyay, M. Tsao, P. Shaw, G. Petersen, S. Gallinger, R. Hruban, A. Maitra, C. Iacobuzio-Donahue, R. Schulick, elliot fishman, R. Morgan, R. Lawlor, P. Capelli, V. Corbo, M. Scardoni, G. Tortora, M. Tempero, K. Mann, N. Jenkins, P. Pérez-Mancera, D. Adams, D. Largaespada, L. Wessels, A. Rust, Lincoln Stein, D. Tuveson, N. Copeland, E. Musgrove, A. Scarpa, J. Eshleman, T. Hudson, R. Sutherland, D. Wheeler, J. Pearson, J. McPherson, R. Gibbs, S. Grimmond (2012)
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genesNature, 491
(2014)
There are multiple additional components of the autophagic process that are potentially targets
Joungmok Kim, M. Kundu, B. Viollet, K. Guan (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Nature Cell Biology, 13
T. Kanzawa, I. Germano, T. Komata, Hideaki Ito, Hideaki Ito, Y. Kondo, Y. Kondo, Seiji Kondo, Seiji Kondo (2004)
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cellsCell Death and Differentiation, 11
E. Tasdemir, M. Maiuri, L. Galluzzi, I. Vitale, M. Djavaheri-Mergny, M. D’Amelio, A. Criollo, E. Morselli, Changlian Zhu, F. Harper, U. Nannmark, C. Samara, P. Pinton, J. Vicencio, R. Carnuccio, U. Moll, F. Madeo, P. Paterlini-Bréchot, R. Rizzuto, G. Szabadkai, G. Pierron, K. Blomgren, Nektarios Tavernarakis, P. Codogno, F. Cecconi, G. Kroemer (2008)
Regulation of autophagy by cytoplasmic p53Nature Cell Biology, 10
Chanhee Kang, Qikai Xu, Timothy Martin, Mamie Li, M. Demaria, Liviu Aron, Tao Lu, B. Yankner, J. Campisi, S. Elledge (2015)
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4Science, 349
(2013)
Breast Palb2flox/flox; Trp53 flox/flox; Wap-cre
Shengbing Huang, F. Sinicrope (2010)
Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cellsAutophagy, 6
S. Melser, Julie Lavie, G. Bénard (2015)
Mitochondrial degradation and energy metabolism.Biochimica et biophysica acta, 1853 10 Pt B
D. Tang, R. Kang, K. Livesey, Chun-Wei Cheh, A. Farkas, P. Loughran, G. Hoppe, M. Bianchi, K. Tracey, H. Zeh, M. Lotze (2010)
Endogenous HMGB1 regulates autophagyThe Journal of Cell Biology, 190
M. Matsushita, N. Suzuki, K. Obara, Y. Fujioka, Y. Ohsumi, F. Inagaki (2007)
Structure of Atg5·Atg16, a Complex Essential for Autophagy*Journal of Biological Chemistry, 282
Anja Apel, I. Herr, H. Schwarz, H. Rodemann, A. Mayer (2008)
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy.Cancer research, 68 5
S. Cloonan, David Williams (2011)
The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug‐resistant Burkitt's lymphomaInternational Journal of Cancer, 128
V. Korolchuk, A. Mansilla, Fiona Menzies, D. Rubinsztein (2009)
Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway SubstratesMolecular Cell, 33
H. Davies, G. Bignell, Charles Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, Mathew Garnett, W. Bottomley, Neil Davis, E. Dicks, Rebecca Ewing, Yvonne Floyd, K. Gray, S. Hall, R. Hawes, Jaime Hughes, Vivian Kosmidou, A. Menzies, Catherine Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, Rebecca Wilson, H. Jayatilake, B. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. Riggins, D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, Judy Ho, Suet Leung, S. Yuen, Barbara Weber, H. Seigler, T. Darrow, H. Paterson, R. Marais, Christopher Marshall, R. Wooster, Michael Stratton, P. Futreal (2002)
Mutations of the BRAF gene in human cancerNature, 417
Alec Kimmelman (2011)
The dynamic nature of autophagy in cancer.Genes & development, 25 19
M. Morgan, Graciela Gamez, C. Menke, Ariel Hernandez, J. Thorburn, Freddi Gidan, Leah Staskiewicz, S. Morgan, C. Cummings, P. Maycotte, A. Thorburn (2014)
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependentAutophagy, 10
(2016)
2015a, Mancias & Kimmelman 2016)
X. Qu, Jie Yu, G. Bhagat, Norihiko Furuya, H. Hibshoosh, A. Troxel, J. Rosen, E. Eskelinen, N. Mizushima, Y. Ohsumi, G. Cattoretti, B. Levine (2003)
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.The Journal of clinical investigation, 112 12
H. Lee, Lisa Mattei, B. Steinberg, P. Alberts, Yun-Hee Lee, A. Chervonsky, N. Mizushima, S. Grinstein, A. Iwasaki (2010)
In vivo requirement for Atg5 in antigen presentation by dendritic cells.Immunity, 32 2
Zhaoju Wu, Pei-Ching Chang, Joy Yang, Cheng-Ying Chu, Ling-Yu Wang, Nien-Tsu Chen, A. Ma, Sonal Desai, S. Lo, C. Evans, K. Lam, H. Kung (2010)
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.Genes & cancer, 1 1
R. Mathew, Sinan Khor, S. Hackett, J. Rabinowitz, David Perlman, E. White (2014)
Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity.Molecular cell, 55 6
A. Williams, Sovan Sarkar, P. Cuddon, Evangelia Ttofi, S. Saiki, Farah Siddiqi, Luca Jahreiss, Angeleen Fleming, Dean Pask, P. Goldsmith, C. O’Kane, R. Floto, D. Rubinsztein (2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.Nature chemical biology, 4 5
V. Kondylis, Hezder Pannerden, Suzanne Dijk, T. Broeke, R. Wubbolts, Willie Geerts, C. Seinen, T. Mutis, H. Heijnen (2013)
Endosome-mediated autophagyAutophagy, 9
C. Kenific, Jayanta Debnath (2015)
Cellular and metabolic functions for autophagy in cancer cells.Trends in cell biology, 25 1
V. Rebecca, R. Amaravadi (2016)
Emerging strategies to effectively target autophagy in cancerOncogene, 35
Autophagy is a highly conserved and regulated process that targets proteins and damaged organelles for lysosomal degradation to maintain cell metabolism, genomic integrity, and cell survival. The role of autophagy in cancer is dynamic and depends, in part, on tumor type and stage. Although autophagy constrains tumor initiation in normal tissue, some tumors rely on autophagy for tumor promotion and maintenance. Studies in genetically engineered mouse models support the idea that autophagy can constrain tumor initiation by regulating DNA damage and oxidative stress. In established tumors, autophagy can also be required for tumor maintenance, allowing tumors to survive environmental stress and providing intermediates for cell metabolism. Autophagy can also be induced in response to chemotherapeutics, acting as a drug-resistance mechanism. Therefore, targeting autophagy is an attractive cancer therapeutic option currently undergoing validation in clinical trials.
Annual Review of Cancer Biology – Annual Reviews
Published: Mar 6, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.