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Nonlinear optics: from theory to applications, with a focus on the use of two-photon absorption in biology

Nonlinear optics: from theory to applications, with a focus on the use of two-photon absorption... The study of nonlinear optics in the 1960s attracted considerable attention from a theoretical standpoint, engendering many proposals for practical use of these new photonic effects. Among these suggestions, the development of efficient two-photon absorption (2PA) has attracted sustained interest due to its demonstrated (or potential) use in a broad range of applications that include optical data storage, optical limiting and nanofabrication. The use of 2PA in biological applications is particularly appealing. This is because 2PA offers several advantages for bio-oriented applications, such as intrinsic three-dimensional resolution, increased penetration depth in biological materials such as tissue and highly focused excitation at half-energy, leading to a decrease of auto-fluorescence and photodamage. In this Primer Review, we introduce the essential background theory needed for an understanding of the field, we describe the key experiments deployed to quantify material performance, we discuss the evolution of 2PA molecular design, and we summarise the state-of-the-art and the existing challenges in the use of 2PA in imaging, therapy and theranostics. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Australian Journal of Chemistry CSIRO Publishing

Nonlinear optics: from theory to applications, with a focus on the use of two-photon absorption in biology

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References (51)

Publisher
CSIRO Publishing
Copyright
Copyright © The Author(s). Published by CSIRO Publishing
ISSN
0004-9425
eISSN
1445-0038
DOI
10.1071/CH23015
Publisher site
See Article on Publisher Site

Abstract

The study of nonlinear optics in the 1960s attracted considerable attention from a theoretical standpoint, engendering many proposals for practical use of these new photonic effects. Among these suggestions, the development of efficient two-photon absorption (2PA) has attracted sustained interest due to its demonstrated (or potential) use in a broad range of applications that include optical data storage, optical limiting and nanofabrication. The use of 2PA in biological applications is particularly appealing. This is because 2PA offers several advantages for bio-oriented applications, such as intrinsic three-dimensional resolution, increased penetration depth in biological materials such as tissue and highly focused excitation at half-energy, leading to a decrease of auto-fluorescence and photodamage. In this Primer Review, we introduce the essential background theory needed for an understanding of the field, we describe the key experiments deployed to quantify material performance, we discuss the evolution of 2PA molecular design, and we summarise the state-of-the-art and the existing challenges in the use of 2PA in imaging, therapy and theranostics.

Journal

Australian Journal of ChemistryCSIRO Publishing

Published: May 12, 2023

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