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Carbohydrate microarrays: key developments in glycobiology

Carbohydrate microarrays: key developments in glycobiology Carbohydrate chains of glycoproteins, glycolipids, proteoglycans, and polysaccharides mediate processes of biological and medical importance through their interactions with complementary proteins. The unraveling of these interactions is therefore a priority in biomedical sciences. Carbohydrate microarray technology is a new development at the frontier of glycomics that is revolutionizing the study of carbohydrate-protein interactions and the elucidation of their specificities in endogenous biological processes, microbe-host interactions, and immune defense mechanisms. In this review, we briefly refer to the principles of numerous platforms since the introduction of carbohydrate microarrays in 2002, and we highlight platforms that are beyond proof-of-concept and have provided new biological information. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Chemistry de Gruyter

Carbohydrate microarrays: key developments in glycobiology

Biological Chemistry , Volume 390 (7) – Jul 1, 2009

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Publisher
de Gruyter
Copyright
©2009 by Walter de Gruyter Berlin New York
Subject
Advancements in analytical techniques
ISSN
1431-6730
eISSN
1437-4315
DOI
10.1515/BC.2009.071
pmid
19426131
Publisher site
See Article on Publisher Site

Abstract

Carbohydrate chains of glycoproteins, glycolipids, proteoglycans, and polysaccharides mediate processes of biological and medical importance through their interactions with complementary proteins. The unraveling of these interactions is therefore a priority in biomedical sciences. Carbohydrate microarray technology is a new development at the frontier of glycomics that is revolutionizing the study of carbohydrate-protein interactions and the elucidation of their specificities in endogenous biological processes, microbe-host interactions, and immune defense mechanisms. In this review, we briefly refer to the principles of numerous platforms since the introduction of carbohydrate microarrays in 2002, and we highlight platforms that are beyond proof-of-concept and have provided new biological information.

Journal

Biological Chemistryde Gruyter

Published: Jul 1, 2009

Keywords: carbohydrate-binding protein; glycolipid; glycoprotein; neoglycolipid; oligosaccharide; polysaccharide

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